https://m2.mtmt.hu/ eng 2026-05-30 21:00 JournalArticle 30799114 VALIDATED true * Megosztott szerzőség 0 false 2026-05-19T10:45:31.379+0000 2023-09-02T15:28:14.439+0000 2019-09-12T10:45:53.691+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2024-06-03T09:26:31.343+0000 2023-09-02T15:28:15.032+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Dézsi, László Complement Activation-Related Pathophysiological Changes in Anesthetized Rats: Activator-Dependent Variations of Symptoms and Mediators of Pseudoallergy true true /api/journal/25013 REVIEWED true false 25013 false 25013 true 1431-5157 1420-3049 Journal FOREIGN 24 18 3283 3283 12 2019 Complement (C) activation can underlie the infusion reactions to liposomes and other nanoparticle-based medicines, a hypersensitivity syndrome that can be partially reproduced in animal models. However, the sensitivities and manifestations substantially differ in different species, and C activation may not be the only cause of pathophysiological changes. In order to map the species variation of C-dependent and -independent pseudoallergy (CARPA/CIPA), here we used known C activators and C activator liposomes to compare their acute hemodynamic, hematological, and biochemical effects in rats. These C activators were cobra venom factor (CVF), zymosan, AmBisome (at 2 doses), its amphotericin B-free vehicle (AmBisombo), and a PEGylated cholesterol-containing liposome (PEG-2000-chol), all having different powers to activate C in rat blood. The pathophysiological endpoints measured were blood pressure, leukocyte and platelet counts, and plasma thromboxane B2, while C activation was assessed by C3 consumption using the Pan-Specific C3 assay. The results showed strong linear correlation between C activation and systemic hypotension, pointing to a causal role of C activation in the hemodynamic changes. The observed thrombocytopenia and leukopenia followed by leukocytosis also correlated with C3 conversion in case of C activators, but not necessarily with C activation by liposomes. These findings are consistent with the double hit hypothesis of hypersensitivity reactions (HSRs), inasmuch as strong C activation can fully account for all symptoms of HSRs, but in case of no-, or weak C activators, the pathophysiological response, if any, is likely to involve other activation pathways. Funding 1978739 /api/funding/1978739 false true Funding 1978740 /api/funding/1978740 false true Funding 1999943 /api/funding/1999943 false true true true 2019 true true true false true false GOLD 2026-05-19 true https://doi.org/10.3390/molecules24183283 16 0 14 10 4 14 14 13 14 14 14 10 10 11 5 0 16 11 14 10 0 13 13 Folyóiratcikk Journal Article 24 14 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 1 Egyéb Miscellaneous 29 1 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2020 0 2 0 2 0 2021 0 4 3 4 3 2022 0 4 3 4 3 2023 0 1 0 1 0 2024 0 3 3 3 3 2025 0 2 2 2 2 Q1 false 10005165,10027489 false false false 2019-09-11T11:05:31.095+0000 Elméleti Egészségtudományok Intézete (ME / ETK); Nanomedicina Kutató és Oktató Központ (SE / AOK / I / KKI); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Intézet (SE / AOK / I) 8 38 4 9 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 87912392 /api/authorship/87912392 1 0.11111111 true false false Author 10005165 /api/author/10005165 Dézsi László true 10005165 true Dézsi László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87912393 /api/authorship/87912393 2 0.11111111 false false false Author 10064003 /api/author/10064003 Mészáros Tamás true 10064003 true Mészáros Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87912394 /api/authorship/87912394 3 0.11111111 false false false Author 10051356 /api/author/10051356 Őrfi Erik true 10051356 true Őrfi Erik true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87912395 /api/authorship/87912395 4 0.11111111 false false false Author 10053120 /api/author/10053120 Fülöp Tamás true 10053120 true Fülöp Tamás G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87912396 /api/authorship/87912396 5 0.11111111 false false false Hennies Mark true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87912397 /api/authorship/87912397 6 0.111 false false false Author 1152552 /api/author/1152552 Rosivall László true 1152552 true Rosivall László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87912523 /api/authorship/87912523 7 0.11111111 false false false Author 10000223 /api/author/10000223 Hamar Péter true 10000223 true Hamar Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87912399 /api/authorship/87912399 8 0.11111111 false true false Author 10003266 /api/author/10003266 Szebeni János true 10003266 true Szebeni János true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 87912400 /api/authorship/87912400 9 0.111 false true true Author 10027489 /api/author/10027489 Szénási Gábor true 10027489 true Szénási Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 15890153 /api/publicationidentifier/15890153 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/molecules24183283 https://doi.org/10.3390/molecules24183283 false true PublicationIdentifier 15984354 /api/publicationidentifier/15984354 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000488830500075 https://www.webofscience.com/wos/woscc/full-record/000488830500075 false true PublicationIdentifier 15895403 /api/publicationidentifier/15895403 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85071929352 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85071929352 false true PublicationIdentifier 15890152 /api/publicationidentifier/15890152 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 31505853 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31505853&dopt=Abstract false true Keyword 11 /api/keyword/11 true 11 true Keyword 69 /api/keyword/69 true 69 true Keyword 2499 /api/keyword/2499 true 2499 true Keyword 6722 /api/keyword/6722 true 6722 true Keyword 14956 /api/keyword/14956 true 14956 true Keyword 1007999 /api/keyword/1007999 true 1007999 true Keyword 1137944 /api/keyword/1137944 true 1137944 true Keyword 1766892 /api/keyword/1766892 true true SjrRating 10872180 /api/sjrrating/10872180 44 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3003 /api/classificationexternal/3003 true 3003 true Q1 DIRECT true true /api/publication/30799114 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10005165"><a href="/gui2/?type=authors&mode=browse&sel=10005165" target="_blank">Dézsi László (<span class="authorship-author-name">Dézsi László</span> <span class="authorAux-mtmt"> Elméleti orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/Nanomedicina Kutató és Oktató Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064003"><a href="/gui2/?type=authors&mode=browse&sel=10064003" target="_blank">Mészáros Tamás (<span class="authorship-author-name">Mészáros Tamás</span> <span class="authorAux-mtmt"> nanomedicina</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10051356"><a href="/gui2/?type=authors&mode=browse&sel=10051356" target="_blank">Őrfi Erik (<span class="authorship-author-name">Őrfi Erik</span> <span class="authorAux-mtmt"> elméleti</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/Nanomedicina Kutató és Oktató Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053120"><a href="/gui2/?type=authors&mode=browse&sel=10053120" target="_blank">Fülöp Tamás G (<span class="authorship-author-name">Fülöp Tamás</span> <span class="authorAux-mtmt"> Liposzomális nanomedicina vizsgálatok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/Nanomedicina Kutató és Oktató Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hennies Mark </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1152552"><a href="/gui2/?type=authors&mode=browse&sel=1152552" target="_blank">Rosivall László (<span class="authorship-author-name">Rosivall László</span> <span class="authorAux-mtmt"> Élettan és kórélettan, nefrológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000223"><a href="/gui2/?type=authors&mode=browse&sel=10000223" target="_blank">Hamar Péter (<span class="authorship-author-name">Hamar Péter</span> <span class="authorAux-mtmt"> Vese immunológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003266"><a href="/gui2/?type=authors&mode=browse&sel=10003266" target="_blank">Szebeni János<sup>**</sup> (<span class="authorship-author-name">Szebeni János</span> <span class="authorAux-mtmt"> Klinikai orvostudomány, immunológia, nanomedicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/Nanomedicina Kutató és Oktató Központ; <span title="University of Miskolc">UM</span>/<span title="Faculty of Health Care Studies">FHCS</span>/Elméleti Egészségtudományok Intézete</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027489"><a href="/gui2/?type=authors&mode=browse&sel=10027489" target="_blank">Szénási Gábor ✉ (<span class="authorship-author-name">Szénási Gábor</span> <span class="authorAux-mtmt"> kórélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30799114" target="_blank">Complement Activation-Related Pathophysiological Changes in Anesthetized Rats: Activator-Dependent Variations of Symptoms and Mediators of Pseudoallergy</a></div> <div> <span class="journal-title">MOLECULES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1431-5157">1431-5157</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1420-3049">1420-3049</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">18</span> <span class="page"> Paper 3283. 12 p. </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/molecules24183283" target="_blank" href="https://doi.org/10.3390/molecules24183283"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000488830500075" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000488830500075"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85071929352" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85071929352"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31505853" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31505853&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Analytical Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Chemistry (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Drug Discovery&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Molecular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 16</span> | Independent citation: 11 | Self citation: 5 | Unknown citation: 0 | Number of citations in WoS: 13 | Number of citations in Scopus:&nbsp;14 | WoS/Scopus assigned:&nbsp;14 | Number of citations with DOI:&nbsp;14 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30799114&sort=publishedYear,desc&sort=title"> Number of cited publications: 13 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 30799114</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed (pubmed_result.xml, 2019-09-12)</span> </div> <div class="funder"> Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Funder: EFOP-VEKOP, (K-113164) Funder: HSRF, Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Funder: EFOP-VEKOP </div> <div class="lastModified">Last Modified: 2023.09.02. 17:28 Róbert Milánkovics (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: * Megosztott szerzőség</pre> </div></div>