Glomerular Collagen Deposition and Lipocalin-2 Expression Are Early Signs of Renal Injury in Prediabetic Obese Rats

https://m2.mtmt.hu/ eng 2026-05-31 11:07 JournalArticle 30789521 VALIDATED true Funding Agency and Grant Number: Hungarian Research Fund [OTKA SNN-114619, ANN-110810, OTKA K116525, OTKA 109737]; National Research, Development and Innovation Fund of Hungary [NVKP_ 16-1-2016-0042, NVKP-16-12016-0017]; Economic Development and Innovation Operative Program [GINOP 2.3.2-15-2016-00048]; Kispal Gyula startup grant [300021]; Semmelweis University [EFOP-3.6.3-VEKOP-16-201700009]; Hungarian Academy of Sciences; Premium Postdoctoral Fellowship Program of the Hungarian Academy of Sciences Funding text: Support was provided by the Hungarian Research Fund: OTKA SNN-114619 (HP), ANN-110810 (HP), OTKA K116525 (CS), OTKA 109737 (PF, ZG), by the National Research, Development and Innovation Fund of Hungary: NVKP_ 16-1-2016-0042 (HP), NVKP-16-12016-0017 (PF, ZG), by the Economic Development and Innovation Operative Program Grant: GINOP 2.3.2-15-2016-00048 (HP). Peter Hamar is a recipient of the Kispal Gyula startup grant (300021) of the University of Pecs. Gabor Koncsos was supported by the Semmelweis University (EFOP-3.6.3-VEKOP-16-201700009). Zoltan Giricz held a 'Janos Bolyai Fellowship' from the Hungarian Academy of Sciences (awarded in 2013 and 2017). Zoltan V. Varga was supported by the Premium Postdoctoral Fellowship Program of the Hungarian Academy of Sciences. 0 false 2026-05-19T10:33:00.026+0000 2024-09-17T07:27:04.475+0000 2019-09-05T11:49:17.398+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Róbert Milánkovics (PTE ÁOK admin 4) true 10039043 2026-03-27T10:19:38.168+0000 2026-03-27T10:19:38.168+0000 2024-09-17T07:27:04.751+0000 true 10073918 Kovács Marcell /api/admin/10073918 Admin Marcell Kovács (MTMT Közp., admin) true Admin 10073918 /api/admin/10073918 Marcell Kovács (MTMT Közp., admin) Kovács Marcell true true 2024-09-09T07:21:55.189+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Bukosza, Eva Nora Glomerular Collagen Deposition and Lipocalin-2 Expression Are Early Signs of Renal Injury in Prediabetic Obese Rats true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 20 17 4266 4266 17 2019 Feeding rats with high-fat diet (HFD) with a single streptozotocin (STZ) injection induced obesity, slightly elevated fasting blood glucose and impaired glucose and insulin tolerance, and caused cardiac hypertrophy and mild diastolic dysfunction as published before by Koncsos et al. in 2016. Here we aimed to explore the renal consequences in the same groups of rats. Male Long-Evans rats were fed normal chow (CON; n = 9) or HFD containing 40% lard and were administered STZ at 20 mg/kg (i.p.) at week four (prediabetic rats, PRED, n = 9). At week 21 blood and urine samples were taken and kidney and liver samples were collected for histology, immunohistochemistry and for analysis of gene expression. HFD and STZ increased body weight and visceral adiposity and plasma leptin concentration. Despite hyperleptinemia, plasma C-reactive protein concentration decreased in PRED rats. Immunohistochemistry revealed elevated collagen IV protein expression in the glomeruli, and Lcn2 mRNA expression increased, while Il-1β mRNA expression decreased in both the renal cortex and medulla in PRED vs. CON rats. Kidney histology, urinary protein excretion, plasma creatinine, glomerular Feret diameter, desmin protein expression, and cortical and medullary mRNA expression of TGF-β1, Nrf2, and PPARγ were similar in CON and PRED rats. Reduced AMPKα phosphorylation of the autophagy regulator Akt was the first sign of liver damage, while plasma lipid and liver enzyme concentrations were similar. In conclusion, glomerular collagen deposition and increased lipocalin-2 expression were the early signs of kidney injury, while most biomarkers of inflammation, oxidative stress and fibrosis were negative in the kidneys of obese, prediabetic rats with mild heart and liver injury. Funding 1999939 /api/funding/1999939 (EFOP-3.6.3-VEKOP-16-2017-00009) false true true false 2019 true true true false true false GOLD 2026-05-19 true https://doi.org/10.3390/ijms20174266 11 0 11 11 0 11 11 9 11 11 11 11 11 11 0 0 11 11 11 11 0 5 5 Folyóiratcikk Journal Article 24 11 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2020 0 1 1 1 1 2021 0 1 1 1 1 2022 0 4 4 4 4 2023 0 4 4 4 4 2024 0 0 0 0 0 2025 0 0 0 0 0 2026 0 1 1 1 1 Q1 false 10027489 false false false 2019-09-04T11:56:21.273+0000 Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); Klinikai Kísérleti Kutató Intézet (SE / KSZE); Kórélettani Intézet (SE / AOK / I); Orvosi Vegytani, Molekuláris Biológiai és Patob... (SE / AOK / I); Transzlációs Medicina Intézet (PTE / ÁOK) 13 52 5 15 0 true 10073918 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 87863114 /api/authorship/87863114 Bukosza, Eva Nora [Bukosza, Éva Nóra (vese immunpathofi...), author] Department of Pathophysiology (SU / FM / I) 1 0.06666667 true false false Author 10049528 /api/author/10049528 Éva Nóra Bukosza (vese immunpathofiziológia) Bukosza Éva Nóra true 10049528 true Bukosza Eva Nora true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 87863115 /api/authorship/87863115 Kaucsár, Tamás [Kaucsár, Tamás (orvostudomány), author] Department of Pathophysiology (SU / FM / I) 2 0.06666667 false false false Author 10034830 /api/author/10034830 Tamás Kaucsár (orvostudomány) Kaucsár Tamás true 10034830 true Kaucsár Tamás true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 87863116 /api/authorship/87863116 Godó, Mária [Godó, Mária (Vese immunológia), author] Department of Pathophysiology (SU / FM / I) 3 0.067 false false false Author 10054757 /api/author/10054757 Mária Godó (Vese immunológia) Godó Mária true 10054757 true Godó Mária true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 87863117 /api/authorship/87863117 Lajtár, Enikő 4 0.067 false false false Lajtár Enikő true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 87863118 /api/authorship/87863118 Tod, Pál [Tod, Pál (Purinerg jelátvit...), author] Department of Pathophysiology (SU / FM / I) 5 0.06666667 false false false Author 10054736 /api/author/10054736 Pál Tod (Purinerg jelátviteli rendszer a központi idegrendszerben) Tod Pál true 10054736 true Tod Pál true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 87863119 /api/authorship/87863119 Koncsos, Gábor [Koncsos, Gábor (Farmakológia), author] Department of Pharmacology and Pharmacotherapy (SU / FM / I) 6 0.06666667 false false false Author 10040913 /api/author/10040913 Gábor Koncsos (Farmakológia) Koncsos Gábor true 10040913 true Koncsos Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 87863120 /api/authorship/87863120 Varga, Zoltán V [Varga, Zoltán (kardiovaszkuláris...), author] Department of Pharmacology and Pharmacotherapy (SU / FM / I) 7 0.06666667 false false false Author 10028393 /api/author/10028393 Zoltán Varga (kardiovaszkuláris kutatás) Varga Zoltán true 10028393 true Varga Zoltán V true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 87863121 /api/authorship/87863121 Baranyai, Tamás [Baranyai, Tamás (Kardiológia), author] Department of Pharmacology and Pharmacotherapy (SU / FM / I) 8 0.06666667 false false false Author 10040912 /api/author/10040912 Tamás Baranyai (Kardiológia) Baranyai Tamás true 10040912 true Baranyai Tamás true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 87863122 /api/authorship/87863122 Nguyen, Minh Tu [Nguyen, Minh Tu (biokémia, molekul...), author] Department of Medical Chemistry, Molecular Biol... (SU / FM / I) 9 0.06666667 false false false Author 10030308 /api/author/10030308 Minh Tu Nguyen (biokémia, molekuláris biológia) Nguyen Minh Tu true 10030308 true Nguyen Minh Tu true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 87863123 /api/authorship/87863123 Schachner, Helga 10 0.06666667 false false false Schachner Helga true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 87863124 /api/authorship/87863124 Sőti, Csaba [Sőti, Csaba (Biokémia, molekul...), author] Department of Medical Chemistry, Molecular Biol... (SU / FM / I) 11 0.06666667 false false false Author 10012506 /api/author/10012506 Csaba Sőti (Biokémia, molekuláris biológia) Sőti Csaba true 10012506 true Sőti Csaba true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 87863125 /api/authorship/87863125 Ferdinandy, Péter [Ferdinandy, Péter (Farmakológia, mol...), author] Department of Pharmacology and Pharmacotherapy (SU / FM / I) 12 0.06666667 false false false Author 10010125 /api/author/10010125 Péter Ferdinandy (Farmakológia, molekuláris medicina) Ferdinandy Péter true 10010125 true Ferdinandy Péter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 87863126 /api/authorship/87863126 Giricz, Zoltán [Giricz, Zoltán (Biokémia, Farmako...), author] Department of Pharmacology and Pharmacotherapy (SU / FM / I) 13 0.067 false false false Author 10026898 /api/author/10026898 Zoltán Giricz (Biokémia, Farmakológia) Giricz Zoltán true 10026898 true Giricz Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 87863127 /api/authorship/87863127 Szénási, Gábor [Szénási, Gábor (kórélettan), author] Department of Pathophysiology (SU / FM / I) 14 0.067 false false false Author 10027489 /api/author/10027489 Gábor Szénási (kórélettan) Szénási Gábor true 10027489 true Szénási Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 87863146 /api/authorship/87863146 Hamar, Péter ✉ [Hamar, Péter (Vese immunológia), author] Department of Pathophysiology (SU / FM / I); Institute for Translational Medicine (UP / UPMS); Klinikai Kísérleti Kutató Intézet (SU / KSZE) 15 0.06666667 false true true Author 10000223 /api/author/10000223 Péter Hamar (Vese immunológia) Hamar Péter true 10000223 true Hamar Péter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 15870966 /api/publicationidentifier/15870966 DOI: 10.3390/ijms20174266 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms20174266 https://doi.org/10.3390/ijms20174266 false true PublicationIdentifier 15922849 /api/publicationidentifier/15922849 REAL: 101402 SwordSource 36 /api/publicationsource/36 REAL PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true REAL REAL http://real.mtak.hu/@@@ true true 36 true GREEN true IDENTICAL 101402 http://real.mtak.hu/101402 false true PublicationIdentifier 15878469 /api/publicationidentifier/15878469 SE Repozitórium: 7617 SwordSource 84 /api/publicationsource/84 SE Repozitórium PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true SE Repozitórium SE Repozitórium https://repo.lib.semmelweis.hu/handle/123456789/@@@ true true 84 true GREEN true IDENTICAL 7617 https://repo.lib.semmelweis.hu/handle/123456789/7617 false true PublicationIdentifier 16015953 /api/publicationidentifier/16015953 WoS: 000486888400198 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000486888400198 https://www.webofscience.com/wos/woscc/full-record/000486888400198 false true PublicationIdentifier 15895411 /api/publicationidentifier/15895411 Scopus: 85071757500 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85071757500 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85071757500 false true PublicationIdentifier 15870965 /api/publicationidentifier/15870965 PubMed: 31480394 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 31480394 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31480394&dopt=Abstract false true Keyword 64 /api/keyword/64 Inflammation true 64 true Keyword 4817 /api/keyword/4817 OBESITY true 4817 true Keyword 1032315 /api/keyword/1032315 Collagen Type IV true 1032315 true Keyword 1527475 /api/keyword/1527475 Lipocalin-2 true true Keyword 1582935 /api/keyword/1582935 Renal Injury true true SjrRating 10770369 /api/sjrrating/10770369 sjr:Q1 (2019) Scopus - Computer Science Applications INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 87 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1706 /api/classificationexternal/1706 Scopus - Computer Science Applications true 1706 true Q1 DIRECT true true /api/publication/30789521 Bukosza Eva Nora et al. Glomerular Collagen Deposition and Lipocalin-2 Expression Are Early Signs of Renal Injury in Prediabetic Obese Rats. (2019) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 20 17<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <a href="/gui2/?type=authors&mode=browse&sel=10049528" target="_blank">Bukosza Eva Nora (Bukosza Éva Nóra vese immunpathofiziológia) </a> SU/FM/I/Department of Pathophysiology ;    <a href="/gui2/?type=authors&mode=browse&sel=10034830" target="_blank">Kaucsár Tamás (Kaucsár Tamás orvostudomány) </a> SU/FM/I/Department of Pathophysiology ;    <a href="/gui2/?type=authors&mode=browse&sel=10054757" target="_blank">Godó Mária (Godó Mária Vese immunológia) </a> SU/FM/I/Department of Pathophysiology ;    Lajtár Enikő ;    <a href="/gui2/?type=authors&mode=browse&sel=10054736" target="_blank">Tod Pál (Tod Pál Purinerg jelátviteli rendszer a központi idegre...) </a> SU/FM/I/Department of Pathophysiology ;    <a href="/gui2/?type=authors&mode=browse&sel=10040913" target="_blank">Koncsos Gábor (Koncsos Gábor Farmakológia) </a> SU/FM/I/Department of Pharmacology and Pharmacotherapy ;    <a href="/gui2/?type=authors&mode=browse&sel=10028393" target="_blank">Varga Zoltán V (Varga Zoltán kardiovaszkuláris kutatás) </a> SU/FM/I/Department of Pharmacology and Pharmacotherapy ;    <a href="/gui2/?type=authors&mode=browse&sel=10040912" target="_blank">Baranyai Tamás (Baranyai Tamás Kardiológia) </a> SU/FM/I/Department of Pharmacology and Pharmacotherapy ;    <a href="/gui2/?type=authors&mode=browse&sel=10030308" target="_blank">Nguyen Minh Tu (Nguyen Minh Tu biokémia, molekuláris biológia) </a> SU/FM/I/Department of Medical Chemistry, Molecular Biology and Pathobiochemistry ;    Schachner Helga ;    <a href="/gui2/?type=authors&mode=browse&sel=10012506" target="_blank">Sőti Csaba (Sőti Csaba Biokémia, molekuláris biológia) </a> SU/FM/I/Department of Medical Chemistry, Molecular Biology and Pathobiochemistry ;    <a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy Péter (Ferdinandy Péter Farmakológia, molekuláris medicina) </a> SU/FM/I/Department of Pharmacology and Pharmacotherapy ;    <a href="/gui2/?type=authors&mode=browse&sel=10026898" target="_blank">Giricz Zoltán (Giricz Zoltán Biokémia, Farmakológia) </a> SU/FM/I/Department of Pharmacology and Pharmacotherapy ;    <a href="/gui2/?type=authors&mode=browse&sel=10027489" target="_blank">Szénási Gábor (Szénási Gábor kórélettan) </a> SU/FM/I/Department of Pathophysiology ;    <a href="/gui2/?type=authors&mode=browse&sel=10000223" target="_blank">Hamar Péter ✉ (Hamar Péter Vese immunológia) </a> SU/FM/I/Department of Pathophysiology; UP/UPMS/Institute for Translational Medicine; SU/KSZE/Klinikai Kísérleti Kutató Intézet </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30789521" target="_blank">Glomerular Collagen Deposition and Lipocalin-2 Expression Are Early Signs of Renal Injury in Prediabetic Obese Rats</a></div> <div> INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>): 20 17 Paper 4266. 17 p. (2019) </div> <div class="pub-footer"> Language: English | <a style="color:blue" title="10.3390/ijms20174266" target="_blank" href="https://doi.org/10.3390/ijms20174266"> DOI </a> <a style="color:blue" title="101402" target="_blank" href="http://real.mtak.hu/101402"> REAL </a> <a style="color:blue" title="7617" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/7617"> SE Repozitórium </a> <a style="color:blue" title="000486888400198" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000486888400198"> WoS </a> <a style="color:blue" title="85071757500" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85071757500"> Scopus </a> <a style="color:blue" title="31480394" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31480394&dopt=Abstract"> PubMed </a> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Computer Science Applications   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Inorganic Chemistry   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Organic Chemistry   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Spectroscopy   Rank: Q1</div> <div class="journal-subject">Journal subject: Scopus - Catalysis   Rank: Q2</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology   Rank: Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> Citing papers: 11 | Independent citation: 11 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 9 | Number of citations in Scopus: 11 | WoS/Scopus assigned: 11 | Number of citations with DOI: 11 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30789521&sort=publishedYear,desc&sort=title"> Number of cited publications: 5 </a> </div> <div class="mtid">Publication: 30789521 | Validated Core Citing | Journal Article ( Article ) | Scientific | PubMed (pubmed_result.xml, 2019-09-05) </div> <div class="funder"> Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Funder: EFOP-VEKOP </div> <div class="lastModified">Last Modified: 2024.09.17. 09:27 Marcell Kovács (MTMT Közp., admin) </div> <div class="lockedBy">Centrally managed 2024.09.09. 09:21 Marcell Kovács (MTMT Közp., admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;">Comments: Funding Agency and Grant Number: Hungarian Research Fund [OTKA SNN-114619, ANN-110810, OTKA K116525, OTKA 109737]; National Research, Development and Innovation Fund of Hungary [NVKP_ 16-1-2016-0042, NVKP-16-12016-0017]; Economic Development and Innovation Operative Program [GINOP 2.3.2-15-2016-00048]; Kispal Gyula startup grant [300021]; Semmelweis University [EFOP-3.6.3-VEKOP-16-201700009]; H...</pre> </div></div>