https://m2.mtmt.hu/ hun 2026-09-21 05:43 JournalArticle 30786727 VALIDATED true Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St., Boston, MA 02115, United States British Heart Foundation Cardiovascular Research Centre, University of Glasgow, 126 University Pl, Glasgow, G12 8TA, United Kingdom Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being, University of Glasgow, Glasgow, United Kingdom National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London, United Kingdom University of Minnesota, Minneapolis, MN, United States Mayo Clinic, Rochester, MN, United States Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China National Heart Center Singapore, Duke–National University of Singapore, Singapore, Singapore National Association of Hospital Cardiologists Research Center, Florence, Italy Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo, Italy National University of Cordoba, Cordoba, Argentina Baylor University Medical Center, Dallas, United States Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin, Berlin, Germany Department of Cardiology, Charité Universitätsmedizin, Campus Virchow–Klinikum, Berlin, Germany Institut de Cardiologie de Montréal, Université de Montréal, Montreal, Canada Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands INSERM Centre d’Investigation Clinic 1433, Université de Lorraine, Centre Hos-pitalier Régional et Universitaire, Nancy, France Medical University of South Carolina, Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, United States National Research Center for Cardiology, Ministry of Health of the Russian Federation, Moscow, Russian Federation Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital, Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona, Spain Department of Heart Failure–Transplantation, National Cardiovascular Institute, Bratislava, Slovakia Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria Discip-lina de Cardiologia Faculdade de Medicina Pontifícia, Universidade Católica de Campinas, São Paulo, Brazil Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland Heart and Vascular Center, Semmelweis University, Budapest, Hungary Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States Novartis Pharmaceuticals, East Hanover, NJ, United States Cited By :498 Export Date: 6 October 2021 CODEN: NEJMA Correspondence Address: Solomon, S.D.; Cardiovascular Division, 75 Francis St., United States; email: ssolomon@bwh.harvard.edu Chemicals/CAS: angiotensin, 1407-47-2; membrane metalloendopeptidase, 82707-54-8, 88201-55-2; natriuretic factor, 9088-07-7; sacubitril plus valsartan, 936623-90-4; valsartan, 137862-53-4; Aminobutyrates; Angiotensin Receptor Antagonists; LCZ 696; Neprilysin; Tetrazoles; Valsartan 0 false 2026-09-18T12:55:58.115+0000 2022-11-24T18:58:22.004+0000 2019-09-04T08:32:34.420+0000 true 10055096 Nagy Regina /api/admin/10055096 Admin true 10055096 2023-07-21T12:20:21.338+0000 2023-07-21T12:20:21.338+0000 2022-11-24T18:58:23.130+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Solomon, Scott D Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction. true true /api/journal/1394667 REVIEWED true false 1394667 false 1394667 true 0028-4793 1533-4406 Journal FOREIGN 381 17 1609 1620 1609 12 2019 The angiotensin receptor-neprilysin inhibitor sacubitril-valsartan led to a reduced risk of hospitalization for heart failure or death from cardiovascular causes among patients with heart failure and reduced ejection fraction. The effect of angiotensin receptor-neprilysin inhibition in patients with heart failure with preserved ejection fraction is unclear.We randomly assigned 4822 patients with New York Heart Association (NYHA) class II to IV heart failure, ejection fraction of 45% or higher, elevated level of natriuretic peptides, and structural heart disease to receive sacubitril-valsartan (target dose, 97 mg of sacubitril with 103 mg of valsartan twice daily) or valsartan (target dose, 160 mg twice daily). The primary outcome was a composite of total hospitalizations for heart failure and death from cardiovascular causes. Primary outcome components, secondary outcomes (including NYHA class change, worsening renal function, and change in Kansas City Cardiomyopathy Questionnaire [KCCQ] clinical summary score [scale, 0 to 100, with higher scores indicating fewer symptoms and physical limitations]), and safety were also assessed.There were 894 primary events in 526 patients in the sacubitril-valsartan group and 1009 primary events in 557 patients in the valsartan group (rate ratio, 0.87; 95% confidence interval [CI], 0.75 to 1.01; P = 0.06). The incidence of death from cardiovascular causes was 8.5% in the sacubitril-valsartan group and 8.9% in the valsartan group (hazard ratio, 0.95; 95% CI, 0.79 to 1.16); there were 690 and 797 total hospitalizations for heart failure, respectively (rate ratio, 0.85; 95% CI, 0.72 to 1.00). NYHA class improved in 15.0% of the patients in the sacubitril-valsartan group and in 12.6% of those in the valsartan group (odds ratio, 1.45; 95% CI, 1.13 to 1.86); renal function worsened in 1.4% and 2.7%, respectively (hazard ratio, 0.50; 95% CI, 0.33 to 0.77). The mean change in the KCCQ clinical summary score at 8 months was 1.0 point (95% CI, 0.0 to 2.1) higher in the sacubitril-valsartan group. Patients in the sacubitril-valsartan group had a higher incidence of hypotension and angioedema and a lower incidence of hyperkalemia. Among 12 prespecified subgroups, there was suggestion of heterogeneity with possible benefit with sacubitril-valsartan in patients with lower ejection fraction and in women.Sacubitril-valsartan did not result in a significantly lower rate of total hospitalizations for heart failure and death from cardiovascular causes among patients with heart failure and an ejection fraction of 45% or higher. 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31475794&dopt=Abstract false true SjrRating 10990189 /api/sjrrating/10990189 4 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true D1 DIRECT true true /api/publication/30786727 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Solomon Scott D </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely Bela (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span 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(34) </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">PARAGON-HF Investigators and Committees</span> </div> <div><a target="_blank" href="/api/publication/30786727?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30786727" target="_blank">Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction.</a></div> <div> <span class="journal-title">NEW ENGLAND JOURNAL OF MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-4793">0028-4793</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1533-4406">1533-4406</a>)</span>: <span class="journal-volume">381</span> <span class="journal-issue">17</span> <span class="page"> pp 1609-1620 </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1056/NEJMoa1908655" target="_blank" href="https://doi.org/10.1056/NEJMoa1908655"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000494692200005" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000494692200005"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85074240365" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85074240365"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="31475794" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31475794&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 2,089</span> | Független: 1,759 | Függő: 330 | Nem jelölt: 0 | WoS jelölt: 1,901 | Scopus jelölt:&nbsp;1,967 | WoS/Scopus jelölt:&nbsp;2,088 | DOI jelölt:&nbsp;2,057 (Nem nyilvános:&nbsp;21) </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30786727&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 30786727</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed (pubmed_result.xml, 2019-09-04)</span> </div> <div class="lastModified">Utolsó módosítás: 2022.11.24. 19:58 Csajbók Edit (SE_KK_Admin5_CSE, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St., Boston, MA 02115, United States British Heart Foundation Cardiovascular Research Centre, University of Glasgow, 126 University Pl, Glasgow, G12 8TA, United Kingdom Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being...</pre> </div></div>