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In an in vitro diabetic apoptosis cell model, we evaluated the function of long noncoding RNA, insulin growth factor 2 antisense (IGF2-AS) in high-glucose-injured human retinal pigment epithelial cells. A human retinal pigment epithelial cell line, ARPE-19 was incubated with high-glucose in vitro to induce apoptosis. SiRNA-mediated IGF2-AS downregulation was conducted in ARPE-19 cells to evaluate its effect on high-glucose induced apoptosis, assessed by a TUNEL assay. qRT-PCR and western blot assays were applied to examine the functional effect of IGF2-AS on IGF2/AKT/Casp-9 expressions in glucose-injured ARPE-19 cells. ART was further knocked down, specifically in IGF2-AS-downregualted ARPE-19 cells, to investigate its functional involvement in IGF2-AS-inhibition-mediated apoptotic protection in glucose-injured ARPE-19 cells. High-glucose induced apoptosis in ARPE-19 cells, and upregulated IGF-2AS in a dose-dependent manner. SiRNA-mediated IGF2-AS downregulation ameliorated apoptosis, upregulated IGF2/AKT and decreased Casp-9, in high-glucose-treated ARPE-19 cells. AKT knockdown was shown to dramatically reverse the preventive effect of IGF2-AS-downregulation on high-glucose-induced apoptosis in ARPE-19 cells. Moreover, it was demonstrated that AKT knockdown directly upregulated Casp-9 in IGF2-AS-downregulated and high-glucose-treated ARPE-19 cells. We demonstrated that inhibiting IGF2-AS, possibly also through activation of AKT signaling pathway, has a protective function in high-glucose-induced apoptosis in human retinal pigment epithelial cells in diabetic retinopathy.", "subjects" : [ { "otype" : "Classification", "mtid" : 10545, "link" : "/api/classification/10545", "label" : "Biológiai tudományok", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 300, "link" : "/api/keyword/300", "label" : "APOPTOSIS", "published" : true, "oldId" : 300, "snippet" : true }, { "otype" : "Keyword", "mtid" : 4855, "link" : "/api/keyword/4855", "label" : "GLUCOSE", "published" : true, "oldId" : 4855, "snippet" : true }, { "otype" : "Keyword", "mtid" : 14093, "link" : "/api/keyword/14093", "label" : "diabetic retinopathy", "published" : true, "oldId" : 14093, "snippet" : true }, { "otype" : "Keyword", "mtid" : 16844, "link" : "/api/keyword/16844", "label" : "AKT", "published" : true, "oldId" : 16844, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1388558, "link" : "/api/keyword/1388558", "label" : "LncRNA", "published" : true, "oldId" : 1388558, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1757749, "link" : "/api/keyword/1757749", "label" : "IGF2-AS", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2019, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2023-01-30", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 1, "citedCount" : 1, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10765173, "link" : "/api/sjrrating/10765173", "label" : "sjr:Q1 (2019) Scopus - Clinical Biochemistry IUBMB LIFE 1521-6543 1521-6551", "listPos" : 26, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 1308, "link" : "/api/classificationexternal/1308", "label" : "Scopus - Clinical Biochemistry", "published" : true, "oldId" : 1308, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : false, "userChangeableUntil" : "2019-12-01T11:50:13.019+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 5, "ownerInstituteCount" : 12, "directInstituteCount" : 0, "authorCount" : 7, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/30780601", "label" : "Yu Xiaoyi et al. 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