{ "labelLang" : "hun", "responseDate" : "2024-03-29 01:54", "content" : { "otype" : "JournalArticle", "mtid" : 30773632, "status" : "APPROVED", "published" : true, "comment" : "Graduate School of Agricultural Science, Tohoku University, Sendai, Japan \n Faculty of Agriculture, Tohoku University, Sendai, Japan \n Comparative Genomics Laboratory, National Institute of Genetics, Mishima, Japan \n Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan \n Life Science Research Center, College of Bioresource Sciences, Nihon University, Fujisawa, Japan \n Hazaka Plant Research Center, Kennan Eisei Kogyo Co., Ltd., Miyagi, Japan \n Cited By :1 \n Export Date: 27 August 2019 \n Correspondence Address: Yabe, S.; Graduate School of Agricultural Science, Tohoku UniversityJapan; email: shuhei.yabe.b2@tohoku.ac.jp \n Funding details: China Scholarship Council, CSC \n Funding details: China Scholarship Council, CSC, 201606330094 \n Funding details: 18K05406, 16H06279 \n Funding details: Institute for Fermentation, Osaka, IFO, G-2018-1-038 \n Funding text 1: This study was supported in part by MEXT/JSPS KAKENHI (Grant Nos. 18K05406 and 16H06279), the Institute for Fermentation, Osaka (Grant No. G-2018-1-038), and the China Scholarship Council (CSC No. 201606330094).\nGraduate School of Agricultural Science, Tohoku University, Sendai, Japan \n Faculty of Agriculture, Tohoku University, Sendai, Japan \n Comparative Genomics Laboratory, National Institute of Genetics, Mishima, Japan \n Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan \n Life Science Research Center, College of Bioresource Sciences, Nihon University, Fujisawa, Japan \n Hazaka Plant Research Center, Kennan Eisei Kogyo Co., Ltd., Miyagi, Japan \n Cited By :7 \n Export Date: 24 August 2020 \n Correspondence Address: Yabe, S.; Graduate School of Agricultural Science, Tohoku UniversityJapan; email: shuhei.yabe.b2@tohoku.ac.jp\nExport Date: 16 July 2021", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2024-02-15T22:07:38.351+0000", "lastModified" : "2024-02-15T22:04:18.736+0000", "created" : "2019-08-27T08:10:59.829+0000", "creator" : { "otype" : "Admin", "mtid" : 10060816, "link" : "/api/admin/10060816", "label" : "Berta Wanda (SZTE admin5)", "familyName" : "Berta", "givenName" : "Wanda", "published" : true, "oldId" : 10060816, "snippet" : true }, "lastDuplumSearch" : "2023-09-12T12:26:41.175+0000", "core" : false, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Zheng, Y.", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 87760364, "link" : "/api/authorship/87760364", "label" : "Zheng, Y. ✉", "listPosition" : 1, "share" : 0.0, "first" : true, "last" : false, "corresponding" : true, "familyName" : "Zheng", "givenName" : "Y.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87760365, "link" : "/api/authorship/87760365", "label" : "Saitou, A.", "listPosition" : 2, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Saitou", "givenName" : "A.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87760366, "link" : "/api/authorship/87760366", "label" : "Wang, C.-M. ✉", "listPosition" : 3, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Wang", "givenName" : "C.-M.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87760367, "link" : "/api/authorship/87760367", "label" : "Toyoda, A. ✉", "listPosition" : 4, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Toyoda", "givenName" : "A.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87760368, "link" : "/api/authorship/87760368", "label" : "Minakuchi, Y. ✉", "listPosition" : 5, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Minakuchi", "givenName" : "Y.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87760369, "link" : "/api/authorship/87760369", "label" : "Sekiguchi, Y. ✉", "listPosition" : 6, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Sekiguchi", "givenName" : "Y.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87760370, "link" : "/api/authorship/87760370", "label" : "Ueda, K.", "listPosition" : 7, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Ueda", "givenName" : "K.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87760371, "link" : "/api/authorship/87760371", "label" : "Takano, H. ✉", "listPosition" : 8, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Takano", "givenName" : "H.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87760372, "link" : "/api/authorship/87760372", "label" : "Sakai, Y. ✉", "listPosition" : 9, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Sakai", "givenName" : "Y.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87760373, "link" : "/api/authorship/87760373", "label" : "Abe, K. ✉", "listPosition" : 10, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Abe", "givenName" : "K.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87760374, "link" : "/api/authorship/87760374", "label" : "Yokota, A. ✉", "listPosition" : 11, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Yokota", "givenName" : "A.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87760375, "link" : "/api/authorship/87760375", "label" : "Yabe, S. ✉", "listPosition" : 12, "share" : 0.0, "first" : false, "last" : true, "corresponding" : true, "familyName" : "Yabe", "givenName" : "S.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true } ], "title" : "Genome features and secondary metabolites biosynthetic potential of the class Ktedonobacteria", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 15836509, "link" : "/api/publicationidentifier/15836509", "label" : "DOI: 10.3389/fmicb.2019.00893", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "oaType" : "GREEN", "oaFree" : true, "validState" : "IDENTICAL", "idValue" : "10.3389/fmicb.2019.00893", "realUrl" : "https://doi.org/10.3389/fmicb.2019.00893", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 16006049, "link" : "/api/publicationidentifier/16006049", "label" : "WoS: 000465859700004", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "https://www.webofscience.com/wos/woscc/full-record/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "000465859700004", "realUrl" : "https://www.webofscience.com/wos/woscc/full-record/000465859700004", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 15836508, "link" : "/api/publicationidentifier/15836508", "label" : "Scopus: 85068163023", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "85068163023", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85068163023", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 19015349, "link" : "/api/publicationidentifier/19015349", "label" : "PubMed: 31080444", "source" : { "otype" : "PlainSource", "mtid" : 17, "link" : "/api/publicationsource/17", "label" : "PubMed", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "PubMed", "nameEng" : "PubMed", "linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "31080444", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31080444&dopt=Abstract", "published" : false, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 10030881, "link" : "/api/journal/10030881", "label" : "FRONTIERS IN MICROBIOLOGY 1664-302X 1664-302X", "pIssn" : "1664-302X", "eIssn" : "1664-302X", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 10030881, "snippet" : true }, "volume" : "10", "internalId" : "893", "firstPageOrInternalIdForSort" : "893", "publishedYear" : 2019, "abstractText" : "The prevalence of antibiotic resistance and the decrease in novel antibiotic discovery in recent years necessitates the identification of potentially novel microbial resources to produce natural products. Ktedonobacteria, a class of deeply branched bacterial lineage in the ancient phylum Chloroflexi, are ubiquitous in terrestrial environments and characterized by their large genome size and complex life cycle. These characteristics indicate Ktedonobacteria as a potential active producer of bioactive compounds. In this study, we observed the existence of a putative “megaplasmid,” multiple copies of ribosomal RNA operons, and high ratio of hypothetical proteins with unknown functions in the class Ktedonobacteria. Furthermore, a total of 104 antiSMASH-predicted putative biosynthetic gene clusters (BGCs) for secondary metabolites with high novelty and diversity were identified in nine Ktedonobacteria genomes. Our investigation of domain composition and organization of the non-ribosomal peptide synthetase and polyketide synthase BGCs further supports the concept that class Ktedonobacteria may produce compounds structurally different from known natural products. Furthermore, screening of bioactive compounds from representative Ktedonobacteria strains resulted in the identification of broad antimicrobial activities against both Gram-positive and Gram-negative tested bacterial strains. Based on these findings, we propose the ancient, ubiquitous, and spore-forming Ktedonobacteria as a versatile and promising microbial resource for natural product discovery. © 2019 Zheng, Saitou, Wang, Toyoda, Minakuchi, Sekiguchi, Ueda, Takano, Sakai, Abe, Yokota and Yabe. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.", "keywords" : [ { "otype" : "Keyword", "mtid" : 1004467, "link" : "/api/keyword/1004467", "label" : "PHYLOGENETIC ANALYSIS", "published" : true, "oldId" : 1004467, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1344478, "link" : "/api/keyword/1344478", "label" : "Whole genome sequencing", "published" : true, "oldId" : 1344478, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1561642, "link" : "/api/keyword/1561642", "label" : "Antimicrobial screening", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1579411, "link" : "/api/keyword/1579411", "label" : "NRPS", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1579413, "link" : "/api/keyword/1579413", "label" : "PKS", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1754880, "link" : "/api/keyword/1754880", "label" : "Class Ktedonobacteria", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1754881, "link" : "/api/keyword/1754881", "label" : "Genome comparisons", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2019, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "GOLD", "oaCheckDate" : "2024-02-15", "oaFree" : true, "oaLink" : "https://doi.org/10.3389/fmicb.2019.00893", "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 1, "citedCount" : 1, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10856100, "link" : "/api/sjrrating/10856100", "label" : "sjr:Q1 (2019) Scopus - Microbiology (medical) FRONTIERS IN MICROBIOLOGY 1664-302X", "listPos" : 16, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2726, "link" : "/api/classificationexternal/2726", "label" : "Scopus - Microbiology (medical)", "published" : true, "oldId" : 2726, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "referenceList" : "Adamek, M., Alanjary, M., Sales-Ortells, H., Goodfellow, M., Bull, A.T., Winkler, A., Comparative genomics reveals phylogenetic distribution patterns of secondary metabolites in Amycolatopsis species (2018) BMC Genomics, 19, p. 426 ;\n Arce-Rodríguez, A., Puente-Sánchez, F., Avendaño, R., Martínez-Cruz, M., De Moor, J.M., Pieper, D.H., Thermoplasmatales and sulfur-oxidizing bacteria dominate the microbial community at the surface water of a CO2-rich hydrothermal spring located in Tenorio Volcano National Park, Costa Rica (2019) Extremophiles, 23, pp. 177-187 ;\n Bérdy, J., Thoughts and facts about antibiotics: Where we are now and where we are heading (2012) J. Antibiot. (Tokyo), 65, pp. 385-395 ;\n Bitok, J.K., Lemetre, C., Ternei, M.A., Brady, S.F., Identification of biosynthetic gene clusters from metagenomic libraries using PPTase complementation in a Streptomyces host (2017) FEMS Microbiol. Lett., 364, p. fnx155 ;\n Björnsson, L., Hugenholtz, P., Tyson, G.W., Blackall, L.L., Filamentous chloroflexi (green non-sulfur bacteria) are abundant in wastewater treatment processes with biological nutrient removal (2002) Microbiology, 148, pp. 2309-2318 ;\n Blin, K., Wolf, T., Chevrette, M.G., Lu, X., Schwalen, C.J., Kautsar, S.A., AntiSMASH 4.0 - Improvements in chemistry prediction and gene cluster boundary identification (2017) Nucleic Acids Res, 45, pp. W36-W41 ;\n Bloudoff, K., Fage, C.D., Marahiel, M.A., Schmeing, T.M., Structural and mutational analysis of the nonribosomal peptide synthetase heterocyclization domain provides insight into catalysis (2017) Proc. Natl. Acad. Sci. U.S.A., 114, pp. 95-100 ;\n Buchanan, B.B., Arnon, D.I., A reverse KREBS cycle in photosynthesis: Consensus at last (1990) Photosynth. Res., 24, pp. 47-53 ;\n Cavaletti, L., Monciardini, P., Bamonte, R., Schumann, P., Rohde, M., Sosio, M., New lineage of filamentous, spore-forming, gram-positive bacteria from soil (2006) Appl. Environ. Microbiol., 72, pp. 4360-4369 ;\n Challis, G.L., Naismith, J.H., Structural aspects of non-ribosomal peptide biosynthesis (2004) Curr. Opin. Struct. Biol., 14, pp. 748-756 ;\n Chang, Y.J., Land, M., Hauser, L., Chertkov, O., Del Rio, T.G., Nolan, M., Non-contiguous finished genome sequence and contextual data of the filamentous soil bacterium Ktedonobacter racemifer type strain (SOSP1-21) (2011) Stand. Genomic Sci., 5, pp. 97-111 ;\n Chater, K.F., Chandra, G., The evolution of development in Streptomyces analysed by genome comparisons (2006) FEMS Microbiol. Rev., 30, pp. 651-672 ;\n Chaudhari, N.M., Gupta, V.K., Dutta, C., BPGA- An ultra-fast pan-genome analysis pipeline (2016) Sci. Rep., 6, p. 24373 ;\n Chen, L.Y., Lai, Y.M., Yang, Y.L., Zhao, X.Q., Genome mining reveals the biosynthetic potential of the marinederived strain Streptomyces marokkonensis M10 (2016) Synth. Syst. Biotechnol., 1, pp. 56-65 ;\n Chen, W.H., Li, K., Guntaka, N.S., Bruner, S.D., Interdomain and intermodule organization in epimerization domain containing nonribosomal peptide synthetases (2016) ACS Chem. Biol., 11, pp. 2293-2303 ;\n Chevrette, M.G., Aicheler, F., Kohlbacher, O., Currie, C.R., Medema, M.H., SandPUMA: Ensemble predictions of nonribosomal peptide chemistry reveal biosynthetic diversity across Actinobacteria (2017) Bioinformatics, 33, pp. 3202-3210 ;\n Chu, J., Vila-Farres, X., Inoyama, D., Ternei, M., Cohen, L.J., Gordon, E.A., Discovery of MRSA active antibiotics using primary sequence from the human microbiome (2016) Nat. Chem. Biol., 12, pp. 1004-1006 ;\n Cimermancic, P., Medema, M.H., Claesen, J., Kurita, K., Wieland, B.L.C., Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters (2014) Cell, 158, pp. 412-421 ;\n Crooks, G.E., Hon, G., Chandonia, J.M., Brenner, S.E., Weblogo: A sequence logo generator (2004) Genome Res, 14, pp. 1188-1190 ;\n Darling, A.C., Mau, B., Blattner, F.R., Perna, N.T., Mauve: Multiple alignment of conserved genomic sequence with rearrangements (2004) Genome Res, 14, pp. 1394-1403 ;\n Darling, A.E., Jospin, G., Lowe, E., Matsen, F.A., IV, Bik, H.M., Eisen, J.A., Phylosift: Phylogenetic analysis of genomes and metagenomes (2014) PeerJ, 2 ;\n Demain, A.L., Sanchez, S., Microbial drug discovery: 80 years of progress (2009) J. Antibiot. (Tokyo), 62, pp. 5-16 ;\n De Miera, L.E.S., Arroyo, P., De Luis Calabuig, E., Ansola, G., Effects of varying CO2 flows on bacterial communities in mesocosms created from two soils (2014) Int. J. Greenhouse Gas Control, 46, pp. 205-214 ;\n De Miera, L.E.S., Arroyo, P., De Luis Calabuig, E., Falagán, J., Ansola, G., High-throughput sequencing of 16S RNA genes of soil bacterial communities from a naturally occurring CO2 gas vent (2014) Int. J. Greenhouse Gas Conrol, 29, pp. 176-184 ;\n Domalaon, R., Idowu, T., Zhanel, G.G., Schweizer, F., Antibiotic hybrids: The next generation of agents and adjuvants against gram-negative pathogens? (2018) Clin. Microbiol. Rev., 31, pp. e00077-e00117 ;\n Donadio, S., Monciardini, P., Sosio, M., Polyketide synthases and nonribosomal peptide synthetases: The emerging view from bacterial genomics (2007) Nat. Prod. Rep., 24, pp. 1073-1109 ;\n Doroghazi, J.R., Metcalf, W.W., Comparative genomics of actinomycetes with a focus on natural product biosynthetic genes (2013) BMC Genomics, 14, p. 611 ;\n Dutta, S., Whicher, J.R., Hansen, D.A., Hale, W.A., Chemler, J.A., Congdon, G.R., Structure of a modular polyketide synthase (2014) Nature, 510, pp. 512-517 ;\n Dziewit, L., Pyzik, A., Szuplewska, M., Matlakowska, R., Mielnicki, S., Wibberg, D., Diversity and role of plasmids in adaptation of bacteria inhabiting the Lubin copper mine in Poland, an environment rich in heavy metals (2015) Front. Microbiol., 3, p. 152 ;\n Errington, J., Regulation of endospore formation in Bacillus subtilis (2003) Nat. Rev. Microbiol., 1, pp. 117-126 ;\n Finn, R.D., Coggill, P., Eberhardt, R.Y., Eddy, S.R., Mistry, J., Mitchell, A.L., The pfam protein families database: Towards a more sustainable future (2016) Nucleic Acids Res, 44, pp. D279-D285 ;\n Flärdh, K., Buttner, M.J., Streptomyces morphogenetics: Dissecting differentiation in a filamentous bacterium (2009) Nat. Rev. Microbiol., 7, pp. 36-49 ;\n Galperin, M.Y., Conserved 'hypothetical' proteins: New hints and new puzzles (2001) Comp. Funct. Genomics, 2, pp. 14-18 ;\n Genilloud, O., Actinomycetes: Still a source of novel antibiotics (2017) Nat. Prod. Rep., 34, pp. 1203-1232 ;\n Grant, J.R., Stothard, P., The CGView server: A comparative genomics tool for circular genomes (2008) Nucleic Acids Res, 36, pp. W181-W184 ;\n Gupta, R.S., Chander, P., George, S., Phylogenetic framework and molecular signatures for the class Chloroflexi and its different clades ;\n proposal for division of the class Chloroflexia class. Nov. Into the suborder Chloroflexineae subord. Nov., consisting of the emended family Oscillochloridaceae and the family Chloroflexaceae fam. Nov., and the suborder Roseiflexineae subord. Nov., containing the family Roseiflexaceae fam. Nov (2013) Antonie van Leeuwenhoek, 103, pp. 99-119 ;\n Han, K., Li, Z.F., Peng, R., Zhu, L.P., Zhou, T., Wang, L.G., Extraordinary expansion of a Sorangium cellulosum genome from an alkaline milieu (2013) Sci. Rep., 3, p. 2101 ;\n Hayashi, T., Kitamura, Y., Funa, N., Ohnishi, Y., Horinouchi, S., Fatty acyl-AMP ligase involvement in the production of alkylresorcylic acid by a Myxococcus xanthus type III polyketide synthase (2011) Chembiochem, 12, pp. 2166-2176 ;\n Hisanaga, Y., Ago, H., Nakagawa, N., Hamada, K., Ida, K., Yamamoto, M., Structural basis of the substrate-specific two-step catalysis of long chain fatty acyl-CoA synthetase dimer (2004) J. Biol. Chem., 279, pp. 31717-31726 ;\n Hug, L.A., Baker, B.J., Anantharaman, K., Brown, C.T., Probst, A.J., Castelle, C.J., A new view of the tree of life (2016) Nat. Microbiol., 1, p. 16048 ;\n Ibal, J.C., Pham, H.Q., Park, C.E., Shin, J.H., Information about variations in multiple copies of bacterial 16S rRNA genes may aid in species identification (2019) PLoS One, 14 ;\n Islam, Z.F., Cordero, P.F.R., Feng, J., Chen, Y.-J., Bay, S.K., Jirapanjawat, T., Two chloroflexi classes independently evolved the ability to persist on atmospheric hydrogen and carbon monoxide (2019) ISME J ;\n Jenke-Kodama, H., Dittmann, E., Evolution of metabolic diversity: Insights from microbial polyketide synthases (2009) Phytochemistry, 70, pp. 1858-1866 ;\n Jenke-Kodama, H., Sandmann, A., Müller, R., Dittmann, E., Evolutionary implications of bacterial polyketide synthases (2005) Mol. Biol. Evol., 22, pp. 2027-2039 ;\n Jensen, P.R., Natural products and the gene cluster revolution (2016) Trends Microbiol, 24, pp. 968-997 ;\n Jiang, X., Ellabaan, M.M., Charusanti, P., Munck, C., Blin, K., Tong, Y., Dissemination of antibiotic resistance genes from antibiotic producers to pathogens (2017) Nat. Commun., 8, p. 15784 ;\n Jiang, Z., Li, P., Jiang, D., Dai, X., Zhang, R., Wang, Y., Microbial community structure and arsenic biogeochemistry in an acid vapor-formed spring in Tengchong Geothermal Area, China (2016) PLoS One, 11 ;\n Johnston, C.W., Skinnider, M.A., Wyatt, M.A., Li, X., Ranieri, M.R., Yang, L., An automated genomes-to-natural products platform (GNP) for the discovery of modular natural products (2015) Nat. Commun., 6, p. 8421 ;\n Kaster, A.K., Mayer-Blackwell, K., Pasarelli, B., Spormann, A.M., Single cell genomic study of Dehalococcoidetes species from deep-sea sediments of the Peruvian Margin (2014) ISME J, 8, pp. 1831-1842 ;\n Kelly, S.L., Kelly, D.E., Microbial cytochromes P450: Biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us? (2013) Philos. Trans. R. Soc. Lond. B Biol. Sci., 6, p. 358 ;\n King, C.E., King, G.M., Description of Thermogemmatispora carboxidivorans sp. Nov., a carbon-monoxide-oxidizing member of the class Ktedonobacteria isolated from a geothermally heated biofilm, and analysis of carbon monoxide oxidation by members of the class Ktedonobacteria (2014) Int. J. Syst. Evol. Microbiol., 64, pp. 1244-1251 ;\n Komaki, H., Hosoyama, A., Yabe, S., Yokota, A., Uchino, Y., Takano, H., Draft genome sequence of Thermogemmatispora onikobensis NBRC 111776T, an aerial mycelium- And spore-forming thermophilic bacterium belonging to the class Ktedonobacteria (2016) Genome Announc, 4, pp. e1156-e1216 ;\n Kuroda, M., Ohta, T., Uchiyama, I., Baba, T., Yuzawa, H., Kobayashi, I., Whole genome sequencing of meticillin-resistant Staphylococcus aureus (2001) Lancet, 357, pp. 1225-1240 ;\n Landry, Z., Swan, B.K., Herndl, G.J., Stepanauskas, R., Giovannoni, S.J., SAR202 genomes from the dark ocean predict pathways for the oxidation of recalcitrant dissolved organic matter (2017) MBio, 8, pp. e413-e417 ;\n Lawrence, J., Selfish operons: The evolutionary impact of gene clustering in prokaryotes and eukaryotes (1999) Curr. Opin. Genet. Dev., 9, pp. 642-648 ;\n Lázár, V., Martins, A., Spohn, R., Daruka, L., Grézal, G., Fekete, G., Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides (2018) Nat. Microbiol., 3, pp. 718-731 ;\n Letunic, I., Bork, P., Interactive tree of life (iTOL) v3: An online tool for the display and annotation of phylogenetic and other trees (2016) Nucleic Acids Res, 44, pp. W242-W245 ;\n Letzel, A.C., Pidot, S.J., Hertweck, C., Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in anaerobic bacteria (2014) BMC Genomics, 15, p. 983 ;\n Li, B., Walsh, C.T., Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus (2010) Proc. Natl. Acad. Sci. U.S.A., 107, pp. 19731-19735 ;\n Liu, F., Garneau, S., Walsh, C.T., Hybrid nonribosomal peptide-polyketide interfaces in epothilone biosynthesis: Minimal requirements at N and C termini of EpoB for elongation (2004) Chem. Biol., 11, pp. 1533-1542 ;\n Ludwig, W., Strunk, O., Westram, R., Richter, L., Meier, H., Yadhukumar, ARB: A software environment for sequence data (2004) Nucleic Acids Res, 32, pp. 1363-1371 ;\n Manivasagan, P., Venkatesan, J., Sivakumar, K., Kim, S.K., Pharmaceutically active secondary metabolites of marine actinobacteria (2014) Microbiol. Res., 169, pp. 262-278 ;\n Masschelein, J., Jenner, M., Challis, G.L., Antibiotics from gram-negative bacteria: A comprehensive overview and selected biosynthetic highlights (2017) Nat. Prod. Rep., 34, pp. 712-783 ;\n Miller, D.A., Luo, L., Hillson, N., Keating, T.A., Walsh, C.T., Yersiniabactin synthetase: A four-protein assembly line producing the nonribosomal peptide/polyketide hybrid siderophore of Yersinia pestis (2002) Chem. Biol., 9, pp. 333-344 ;\n Miller, S.I., Antibiotic resistance and regulation of the gram-negative bacterial outer membrane barrier by host innate immune molecules (2016) MBio, 7, pp. e1541-e11516 ;\n Moe, W.M., Yan, J., Nobre, M.F., Da Costa, M.S., Rainey, F.A., Dehalogenimonas lykanthroporepellens gen. Nov., sp. Nov., a reductively dehalogenating bacterium isolated from chlorinated solvent-contaminated groundwater (2009) Int. J. Syst. Evol. Microbiol., 59, pp. 2692-2697 ;\n Moriya, Y., Itoh, M., Okuda, S., Yoshizawa, A., Kanehisa, M., KaaS: An automatic genome annotation and pathway reconstruction server (2007) Nucleic Acids Res, 35, pp. W182-W185 ;\n Naughton, L.M., Romano, S., O'Gara, F., Dobson, A.D.W., Identification of secondary metabolite gene clusters in the Pseudovibrio genus reveals encouraging biosynthetic potential toward the production of novel bioactive compounds (2017) Front. Microbiol., 8, p. 1494 ;\n Northup, D.E., Melim, L.A., Spilde, M.N., Hathaway, J.J., Garcia, M.G., Moya, M., Lav cave microbial communities within mats and secondary mineral deposits: Implications for life detection on other planets (2011) Astrobiology, 11, pp. 601-618 ;\n Okada, Y., Occurrence of masses of gelatinous microbes in the soil (1937) Soil Sci, 43, pp. 367-374 ;\n Omura, S., Ikeda, H., Ishikawa, J., Hanamoto, A., Takahashi, C., Shinose, M., Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites (2001) Proc. Natl. Acad. Sci. U.S.A., 98, pp. 12215-12220 ;\n Ortega, M.A., Hao, Y., Zhang, Q., Walker, M.C., Van Der Donk, W.A., Nair, S.K., Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB (2015) Nature, 517, pp. 509-512 ;\n Ortega, M.A., Van Der Donk, W.A., New insights into the biosynthetic logic of ribosomally synthesized and post-translationally modified peptide natural products (2016) Cell Chem. Biol., 23, pp. 31-44 ;\n Pal, C., Bengtsson-Palme, J., Kristiansson, E., Larsson, D.G., The structure and diversity of human, animal and environmental resistomes (2016) Microbiome, 4, p. 54 ;\n Park, J.S., Kagaya, N., Hashimoto, J., Izumikawa, M., Yabe, S., Shin-Ya, K., Identification and biosynthesis of new acyloins from the thermophilic bacterium Thermosporothrix hazakensis SK20-1(T) (2014) Chembiochem, 15, pp. 527-532 ;\n Park, J.S., Yabe, S., Shin-Ya, K., Nishiyama, M., Kuzuyama, T., New 2-(1'H-indole-3'-carbonyl)-thiazoles derived from the thermophilic bacterium Thermosporothrix hazakensis SK20-1(T) (2015) J. Antibiot. (Tokyo), 68, pp. 60-62 ;\n Parks, D.H., Imelfort, M., Skennerton, C.T., Hugenholtz, P., Tyson, G.W., CheckM: Assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes (2015) Genome Res, 25, pp. 1043-1055 ;\n Price, M.N., Dehal, P.S., Arkin, A.P., FastTree 2-approximately maximum-likelihood trees for large alignments (2010) PLoS One, 5 ;\n Rausch, C., Hoof, I., Weber, T., Wohlleben, W., Huson, D.H., Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution (2007) BMC Evol. Biol., 7, p. 78 ;\n Romaniuk, K., Golec, P., Dziewit, L., Insight into the diversity and possible role of plasmids in the adaptation of psychrotolerant and metalotolerant Arthrobacter spp. To extreme Antarctic environments (2018) Front. Microbiol., 9, p. 3144 ;\n Röttig, M., Medema, M.H., Blin, K., Weber, T., Rausch, C., Kohlbacher, O., NRPSpredictor2-a web server for predicting NRPS adenylation domain specificity (2011) Nucleic Acids Res, 39, pp. W362-W367 ;\n Rutledge, P.J., Challis, G.L., Discovery of microbial natural products by activation of silent biosynthetic gene clusters (2015) Nat. Rev. Microbiol., 13, pp. 509-523 ;\n Sabath, N., Ferrada, E., Barve, A., Wagner, A., Growth temperature and genome size in bacteria are negatively correlated, suggesting genomic streamlining during thermal adaptation (2013) Genome Biol. Evol., 5, pp. 966-977 ;\n Sekiguchi, Y., Ohashi, A., Parks, D.H., Yamauchi, T., Tyson, G.W., Hugenholtz, P., First genomic insights into members of a candidate bacterial phylum responsible for wastewater bulking (2015) PeerJ, 3 ;\n Shen, B., Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms (2003) Curr. Opin. Chem. Biol., 7, pp. 285-295 ;\n Shirling, E.B., Gottlieb, D., Methods for characterization of Streptomyces species (1966) Int. J. Syst. Bacteriol., 16, pp. 313-340 ;\n Shou, Q., Feng, L., Long, Y., Han, J., Nunnery, J.K., Powell, D.H., A hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival (2016) Nat. Chem. Biol., 12, pp. 770-772 ;\n Soo, R.M., Skennerton, C.T., Sekiguchi, Y., Imelfort, M., Paech, S.J., Dennis, P.G., An expanded genomic representation of the phylum Cyanobacteria (2014) Genome Biol. Evol., 6, pp. 1031-1045 ;\n Soupene, E., Kuypers, F.A., Mammalian long-chain acyl-CoA synthetases (2008) Exp. Biol. Med. (Maywood), 233, pp. 507-521 ;\n Stachelhaus, T., Mootz, H.D., Marahiel, M.A., The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases (1999) Chem. Biol., 6, pp. 493-505 ;\n Stamatakis, A., RAxML-VI-HPC: Maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models (2006) Bioinformatics, 22, pp. 2688-2690 ;\n Stres, B., Sul, W.J., Murovec, B., Tiedje, J.M., Recently deglaciated high-altitude soils of the Himalaya: Diverse environments, heterogenous bacterial communities and long-range dust inputs from the upper troposphere (2013) PLoS One, 8 ;\n Sun, L., Toyonaga, M., Ohashi, A., Tourlousse, D.M., Matsuura, N., Meng, X.Y., Lentimicrobium saccharophilum gen. Nov., sp. Nov., a strictly anaerobic bacterium representing a new family in the phylum Bacteroidetes, and proposal of Lentimicrobiaceae fam. Nov (2016) Int. J. Syst. Evol. Microbiol., 66, pp. 2635-2642 ;\n Swofford, D.L., (2003) PAUP∗: Phylogenetic Analysis Using Parsimony, , https://paup.phylosolutions.com/, Version 4.0b10.: accessed September 2018 ;\n Tanizawa, Y., Fujisawa, T., Nakamura, Y., DFAST: A flexible prokaryotic genome annotation pipeline for faster genome publication (2018) Bioinformatics, 34, pp. 1037-1039 ;\n Tebo, B.M., Davis, R.E., Anitori, R.P., Connell, L.B., Schiffman, P., Staudigel, H., Microbial communities in dark oligotrophic volcanic ice cave ecosystems of Mt. Erebus, Antarctica (2015) Front. Microbiol., 6, p. 179 ;\n Tettelin, H., Masignani, V., Cieslewicz, M.J., Donati, C., Medini, D., Ward, N.L., Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: Implications for the microbial “pan-genome (2005) Proc. Natl. Acad. Sci. U.S.A., 102, pp. 13950-13955 ;\n Thomas, C.M., Summers, D., Bacterial plasmids (2008) Encyclopedia of Life Sciences (ELS), , Chichester: John Wiley & Sons, Ltd ;\n Tooming-Klunderud, A., Sogge, H., Rounge, T.B., Nederbragt, A.J., Lagesen, K., Glöckner, G., From green to red: Horizontal gene transfer of the phycoerythrin gene cluster between Planktothrix strains (2013) Appl. Environ. Microbiol., 79, pp. 6803-6812 ;\n Van Heel, A.J., De Jong, A., Montalbán-López, M., Kok, J., Kuipers, O.P., Bagel3: Automated identification of genes encoding bacteriocins and (non-)bactericidal posttranslationally modified peptides (2013) Nucleic Acids Res, 41, pp. W448-W453 ;\n Vila-Farres, X., Chu, J., Inoyama, D., Ternei, M.A., Lemetre, C., Cohen, L.J., Antimicrobials inspired by nonribosomal peptide synthetase gene clusters (2017) J. Am. Chem. Soc., 139, pp. 1404-1407 ;\n Wang, C.M., Zheng, Y., Sakai, Y., Toyoda, A., Minakuchi, Y., Abe, K., Tengunoibacter tsumagoiensis gen. Nov., sp. Nov., Dictyobacter kobayashii sp. Nov., Dictyobacter alpinus sp. Nov., and description of Dictyobacteraceae fam. Nov. Within the order Ktedonobacterales isolated from Tengu-no-mugimeshi, a soil-like granular mass of microorganisms, and emended descriptions of the genera Ktedonobacter and Dictyobacter (2019) Int. J. Syst. Evol.Microbiol., 69. , press ;\n Willey, J.M., Van Der Donk, W.A., Lantibiotics: Peptides of diverse structure and function (2007) Annu. Rev. Microbiol., 61, pp. 477-501 ;\n Wu, D., Raymond, J., Wu, M., Chatterji, S., Ren, Q., Graham, J.E., Complete genome sequence of the aerobic CO-oxidizing thermophile Thermomicrobium roseum (2009) PLoS One, 4 ;\n Xu, B., Aitken, E.J., Baker, B.P., Turner, C.A., Harvey, J.E., Stott, M.B., Genome mining, isolation, chemical synthesis and biological evaluation of a novel lanthipeptide, tikitericin, from the extremophilic microorganism Thermogemmatispora strain T81 (2018) Chem. Sci., 9, pp. 7311-7317 ;\n Yabe, S., Aiba, Y., Sakai, Y., Hazaka, M., Yokota, A., Thermosporothrix hazakensis gen. Nov., sp. Nov., isolated from compost, description of Thermosporotrichaceae fam. Nov. Within the class Ktedonobacteria Cavaletti et al. 2007 and emended description of the class Ktedonobacteria (2010) Int. J. Syst. Evol. Microbiol., 60, pp. 1794-1801 ;\n Yabe, S., Aiba, Y., Sakai, Y., Hazaka, M., Yokota, A., Thermogemmatispora onikobensis gen. Nov., sp. Nov. And thermogemmatispora foliorum sp. Nov., isolated from fallen leaves on geothermal soils, and description of Thermogemmatisporaceae fam. Nov. And Thermogemmatisporales ord. Nov. And the class Ktedonobacteria (2011) Int. J. Syst. Evol. Microbiol., 61, pp. 903-910 ;\n Yabe, S., Sakai, Y., Abe, K., Yokota, A., Diversity of Ktedonobacteria with actinomycetes-like morphology in terrestrial environments (2017) Microbes Environ, 31, pp. 61-70 ;\n Yabe, S., Sakai, Y., Abe, K., Yokota, A., Také, A., Matsumoto, A., Dictyobacter aurantiacus gen. Nov., sp. Nov., a member of the family Ktedonobacteraceae, isolated from soil, and emended description of the genus Thermosporothrix (2017) Int. J. Syst. Evol. Microbiol., 67, pp. 2615-2621 ;\n Yabe, S., Wang, C.M., Zheng, Y., Sakai, Y., Abe, K., Yokota, A., Formation of sporangiospores in Dictyobacter aurantiacus (class Ktedonobacteria in phylum Chloroflexi) (2019) J. Gen. Appl. Microbiol., 65. , press ;\n Yarza, P., Ludwig, W., Euzéby, J., Amann, R., Schleifer, K.H., Glöckner, F.O., Update of the all-species living tree project based on 16S and 23S rRNA sequence analyses (2010) Syst. Appl. Microbiol., 33, pp. 291-299 ;\n Zhang, Q., Yu, Y., Vélasquez, J.E., Van Der Donk, W.A., Evolution of lanthipeptide synthetases (2012) Proc. Natl. Acad. Sci. U.S.A., 109, pp. 18361-18366 ;\n Ziemert, N., Lechner, A., Wietz, M., Millán-Aguiñaga, N., Chavarria, K.L., Jensen, P.R., Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora (2014) Proc. Natl. Acad. Sci. U.S.A., 111, pp. E1130-E1139 ;\n Ziemert, N., Podell, S., Penn, K., Badger, J.H., Allen, E., Jensen, P.R., The natural product domain seeker NaPDoS: A phylogeny based bioinformatic tool to classify secondary metabolite gene diversity (2012) PLoS One, 7", "hasCitationDuplums" : false, "userChangeableUntil" : "2019-08-26T08:34:44.903+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 25, "ownerInstituteCount" : 64, "directInstituteCount" : 0, "authorCount" : 12, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/30773632", "label" : "Zheng Y. et al. Genome features and secondary metabolites biosynthetic potential of the class Ktedonobacteria. (2019) FRONTIERS IN MICROBIOLOGY 1664-302X 1664-302X 10", "template" : "