Insights into Chagas treatment based on the potential of bacteriocin AS-48

Martín-Escolano, R. ✉; Cebrián, R. ✉; Martín-Escolano, J.; Rosales, M.J. ✉; Maqueda, M. ✉; Sánchez-Moreno, M. ✉; Marín, C. ✉

Angol nyelvű Tudományos Szakcikk (Folyóiratcikk)
  • SJR Scopus - Pharmacology (medical): Q1
Chagas disease caused by the protozoan parasite Trypanosoma cruzi represents a significant public health problem in Latin America, affecting around 8 million cases worldwide. Nowadays is urgent the identification of new antichagasic agents as the only therapeutic options available, Nifurtimox and Benznidazole, are in use for >40 years, and present high toxicity, limited efficacy and frequent treatment failures in the chronic phase of the disease. Recently, it has been described the antiparasitic effect of AS-48, a bacteriocin produced by Enterococcus faecalis, against Trypanosoma brucei and Leishmania spp. In this work, we have demonstrated the in vitro potential of the AS-48 bacteriocin against T. cruzi. Interesting, AS-48 was more effective against the three morphological forms of different T. cruzi strains, and displayed lower cytotoxicity than the reference drug Benznidazole. In addition, AS-48 combines the criteria established as a potential antichagasic agent, resulting in a promising therapeutic alternative. According to the action mechanism, AS-48 trypanocidal activity could be explained in a mitochondrion-dependent manner through a reactive oxygen species production and mitochondrial depolarization, causing a fast and severe bioenergetic collapse. © 2019 The Authors
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2020-06-06 00:13