{ "labelLang" : "hun", "responseDate" : "2024-03-28 16:45", "content" : { "otype" : "JournalArticle", "mtid" : 30748558, "status" : "VALIDATED", "published" : true, "comment" : "Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, United States \n Scripps Research Institute, Jupiter, FL 33458, United States \n Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan \n Export Date: 26 July 2019 \n Correspondence Address: Godlewski, G.; Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of HealthUnited States; email: greg.godlewski@nih.gov \n Chemicals/CAS: carnitine, 461-06-3, 541-15-1, 56-99-5; ghrelin, 304853-26-7; palmitoylcarnitine, 1935-18-8, 2364-67-2 \n Funding details: National Institute on Alcohol Abuse and Alcoholism \n Funding text 1: We thank Dr. Jeffrey M. Zigman for valuable discussions and advice. This work was supported by intramural funds from the National Institute on Alcohol Abuse and Alcoholism to G.K.\nLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, United States \n Scripps Research Institute, Jupiter, FL 33458, United States \n Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan \n Export Date: 16 October 2019 \n Correspondence Address: Godlewski, G.; Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of HealthUnited States; email: greg.godlewski@nih.gov \n Chemicals/CAS: carnitine, 461-06-3, 541-15-1, 56-99-5; ghrelin, 304853-26-7; palmitoylcarnitine, 1935-18-8, 2364-67-2 \n Funding details: National Institute on Alcohol Abuse and Alcoholism \n Funding text 1: We thank Dr. Jeffrey M. Zigman for valuable discussions and advice. This work was supported by intramural funds from the National Institute on Alcohol Abuse and Alcoholism to G.K.\nLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, United States \n Scripps Research Institute, Jupiter, FL 33458, United States \n Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan \n Cited By :4 \n Export Date: 26 March 2020 \n Correspondence Address: Godlewski, G.; Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of HealthUnited States; email: greg.godlewski@nih.gov \n Chemicals/CAS: carnitine, 461-06-3, 541-15-1, 56-99-5; ghrelin, 304853-26-7; palmitoylcarnitine, 1935-18-8, 2364-67-2 \n Funding details: National Institute on Alcohol Abuse and Alcoholism, NIAAA \n Funding text 1: We thank Dr. Jeffrey M. Zigman for valuable discussions and advice. This work was supported by intramural funds from the National Institute on Alcohol Abuse and Alcoholism to G.K.\nLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, United States \n Scripps Research Institute, Jupiter, FL 33458, United States \n Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan \n Cited By :7 \n Export Date: 7 August 2020 \n Correspondence Address: Godlewski, G.; Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of HealthUnited States; email: greg.godlewski@nih.gov \n Chemicals/CAS: carnitine, 461-06-3, 541-15-1, 56-99-5; ghrelin, 304853-26-7; palmitoylcarnitine, 1935-18-8, 2364-67-2 \n Funding details: National Institute on Alcohol Abuse and Alcoholism, NIAAA \n Funding text 1: We thank Dr. Jeffrey M. Zigman for valuable discussions and advice. This work was supported by intramural funds from the National Institute on Alcohol Abuse and Alcoholism to G.K.\nLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, United States \n Scripps Research Institute, Jupiter, FL 33458, United States \n Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan \n Cited By :12 \n Export Date: 30 January 2021 \n Correspondence Address: Godlewski, G.; Laboratory of Physiologic Studies, United States; email: greg.godlewski@nih.gov \n Chemicals/CAS: carnitine, 461-06-3, 541-15-1, 56-99-5; ghrelin, 304853-26-7; palmitoylcarnitine, 1935-18-8, 2364-67-2; acyltransferase, 9012-30-0, 9054-54-0; Acyltransferases; CNR1 protein, mouse; Ghrelin; ghrelin, des-n-octanoyl; JD5037; Mboat4 protein, mouse; Membrane Proteins; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Ghrelin; Sulfonamides \n Funding details: National Institute on Alcohol Abuse and Alcoholism, NIAAA \n Funding text 1: We thank Dr. Jeffrey M. Zigman for valuable discussions and advice. This work was supported by intramural funds from the National Institute on Alcohol Abuse and Alcoholism to G.K.\nLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, United States \n Scripps Research Institute, Jupiter, FL 33458, United States \n Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan \n Cited By :13 \n Export Date: 1 April 2021 \n Correspondence Address: Godlewski, G.; Laboratory of Physiologic Studies, United States; email: greg.godlewski@nih.gov \n Chemicals/CAS: carnitine, 461-06-3, 541-15-1, 56-99-5; ghrelin, 304853-26-7; palmitoylcarnitine, 1935-18-8, 2364-67-2; acyltransferase, 9012-30-0, 9054-54-0; Acyltransferases; CNR1 protein, mouse; Ghrelin; ghrelin, des-n-octanoyl; JD5037; Mboat4 protein, mouse; Membrane Proteins; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Ghrelin; Sulfonamides \n Funding details: National Institute on Alcohol Abuse and Alcoholism, NIAAA, ZIAAA000351 \n Funding text 1: We thank Dr. Jeffrey M. Zigman for valuable discussions and advice. This work was supported by intramural funds from the National Institute on Alcohol Abuse and Alcoholism to G.K.\nLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, United States \n Scripps Research Institute, Jupiter, FL 33458, United States \n Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan \n Cited By :14 \n Export Date: 12 August 2021 \n Correspondence Address: Godlewski, G.; Laboratory of Physiologic Studies, United States; email: greg.godlewski@nih.gov \n Chemicals/CAS: carnitine, 461-06-3, 541-15-1, 56-99-5; ghrelin, 304853-26-7; palmitoylcarnitine, 1935-18-8, 2364-67-2; acyltransferase, 9012-30-0, 9054-54-0; Acyltransferases; CNR1 protein, mouse; Ghrelin; ghrelin, des-n-octanoyl; JD5037; Mboat4 protein, mouse; Membrane Proteins; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Ghrelin; Sulfonamides \n Funding details: National Institute on Alcohol Abuse and Alcoholism, NIAAA, ZIAAA000351 \n Funding text 1: We thank Dr. Jeffrey M. Zigman for valuable discussions and advice. This work was supported by intramural funds from the National Institute on Alcohol Abuse and Alcoholism to G.K.", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2023-02-14T10:28:20.899+0000", "lastModified" : "2023-02-08T13:52:32.423+0000", "created" : "2019-07-26T15:13:36.237+0000", "creator" : { "otype" : "Author", "mtid" : 10015491, "link" : "/api/author/10015491", "label" : "Szanda Gergő (Molekuláris Élettan)", "familyName" : "Szanda", "givenName" : "Gergő", "published" : true, "oldId" : 10015491, "snippet" : true }, "lastDuplumOK" : "2024-01-15T13:29:59.281+0000", "lastDuplumSearch" : "2024-01-15T13:29:59.281+0000", "validated" : "2019-11-10T23:42:18.857+0000", "validator" : { "otype" : "Admin", "mtid" : 10013822, "link" : "/api/admin/10013822", "label" : "WoS admin-2 -1 (WoS import 3, admin)", "familyName" : "WoS admin-2", "givenName" : "-1", "published" : true, "oldId" : 10013822, "snippet" : true }, "core" : false, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Godlewski, G.", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 87625631, "link" : "/api/authorship/87625631", "label" : "Godlewski, G. ✉", "listPosition" : 1, "share" : 0.0, "first" : true, "last" : false, "corresponding" : true, "familyName" : "Godlewski", "givenName" : "G.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87625632, "link" : "/api/authorship/87625632", "label" : "Cinar, R. ✉", "listPosition" : 2, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Cinar", "givenName" : "R.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87625633, "link" : "/api/authorship/87625633", "label" : "Coffey, N.J.", "listPosition" : 3, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Coffey", "givenName" : "N.J.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87625634, "link" : "/api/authorship/87625634", "label" : "Liu, J. ✉", "listPosition" : 4, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Liu", "givenName" : "J.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87625635, "link" : "/api/authorship/87625635", "label" : "Jourdan, T. ✉", "listPosition" : 5, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Jourdan", "givenName" : "T.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87625636, "link" : "/api/authorship/87625636", "label" : "Mukhopadhyay, B. ✉", "listPosition" : 6, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Mukhopadhyay", "givenName" : "B.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87625637, "link" : "/api/authorship/87625637", "label" : "Chedester, L.", "listPosition" : 7, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Chedester", "givenName" : "L.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87625638, "link" : "/api/authorship/87625638", "label" : "Liu, Z.", "listPosition" : 8, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Liu", "givenName" : "Z.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87625639, "link" : "/api/authorship/87625639", "label" : "Osei-Hyiaman, D. ✉", "listPosition" : 9, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Osei-Hyiaman", "givenName" : "D.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87625640, "link" : "/api/authorship/87625640", "label" : "Iyer, M.R.", "listPosition" : 10, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Iyer", "givenName" : "M.R.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87625641, "link" : "/api/authorship/87625641", "label" : "Park, J.K.", "listPosition" : 11, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Park", "givenName" : "J.K.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87625642, "link" : "/api/authorship/87625642", "label" : "Smith, R.G. ✉", "listPosition" : 12, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Smith", "givenName" : "R.G.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87625643, "link" : "/api/authorship/87625643", "label" : "Iwakura, H. ✉", "listPosition" : 13, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Iwakura", "givenName" : "H.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 87625644, "link" : "/api/authorship/87625644", "label" : "Kunos, G. ✉", "listPosition" : 14, "share" : 0.0, "first" : false, "last" : true, "corresponding" : true, "familyName" : "Kunos", "givenName" : "G.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true } ], "title" : "Targeting Peripheral CB1 Receptors Reduces Ethanol Intake via a Gut-Brain Axis", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 15744668, "link" : "/api/publicationidentifier/15744668", "label" : "DOI: 10.1016/j.cmet.2019.04.012", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "10.1016/j.cmet.2019.04.012", "realUrl" : "https://doi.org/10.1016/j.cmet.2019.04.012", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 20506876, "link" : "/api/publicationidentifier/20506876", "label" : "ISSN: 1932-7420", "source" : { "otype" : "PlainSource", "mtid" : 123, "link" : "/api/publicationsource/123", "label" : "ISSN", "type" : { "otype" : "PublicationSourceType", "mtid" : 10002, "link" : "/api/publicationsourcetype/10002", "label" : "Egyéb", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "ISSN", "nameEng" : "ISSN", "linkPattern" : "https://portal.issn.org/resource/ISSN/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 123, "snippet" : true }, "oaType" : "NONE", "validState" : "IDENTICAL", "idValue" : "1932-7420", "realUrl" : "https://portal.issn.org/resource/ISSN/1932-7420", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 16062558, "link" : "/api/publicationidentifier/16062558", "label" : "WoS: 000470097200010", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "https://www.webofscience.com/wos/woscc/full-record/WOS:@@@", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "000470097200010", "realUrl" : "https://www.webofscience.com/wos/woscc/full-record/WOS:000470097200010", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 15744667, "link" : "/api/publicationidentifier/15744667", "label" : "Scopus: 85066256868", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "85066256868", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85066256868", "published" : false, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 10003019, "link" : "/api/journal/10003019", "label" : "CELL METABOLISM 1550-4131 1932-7420", "pIssn" : "1550-4131", "eIssn" : "1932-7420", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 10003019, "snippet" : true }, "volume" : "29", "issue" : "6", "firstPage" : "1320", "lastPage" : "1333.e8", "firstPageOrInternalIdForSort" : "1320", "publishedYear" : 2019, "abstractText" : "Endocannabinoids acting on the cannabinoid-1 receptor (CB1R) or ghrelin acting on its receptor (GHS-R1A) both promote alcohol-seeking behavior, but an interaction between the two signaling systems has not been explored. Here, we report that the peripheral CB1R inverse agonist JD5037 reduces ethanol drinking in wild-type mice but not in mice lacking CB1R, ghrelin peptide or GHS-R1A. JD5037 treatment of alcohol-drinking mice inhibits the formation of biologically active octanoyl-ghrelin without affecting its inactive precursor desacyl-ghrelin. In ghrelin-producing stomach cells, JD5037 reduced the level of the substrate octanoyl-carnitine generated from palmitoyl-carnitine by increasing fatty acid β-oxidation. Blocking gastric vagal afferents abrogated the ability of either CB1R or GHS-R1A blockade to reduce ethanol drinking. We conclude that blocking CB1R in ghrelin-producing cells reduces alcohol drinking by inhibiting the formation of active ghrelin and its signaling via gastric vagal afferents. Thus, peripheral CB1R blockade may have therapeutic potential in the treatment of alcoholism. © 2019", "keywords" : [ { "otype" : "Keyword", "mtid" : 446, "link" : "/api/keyword/446", "label" : "ACYLATION", "published" : true, "oldId" : 446, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1699, "link" : "/api/keyword/1699", "label" : "ARTICLE", "published" : true, "oldId" : 1699, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2084, "link" : "/api/keyword/2084", "label" : "MOUSE", "published" : true, "oldId" : 2084, "snippet" : true }, { "otype" : "Keyword", "mtid" : 3171, "link" : "/api/keyword/3171", "label" : "OXIDATION", "published" : true, "oldId" : 3171, "snippet" : true }, { "otype" : "Keyword", "mtid" : 4600, "link" : "/api/keyword/4600", "label" : "priority journal", "published" : true, "oldId" : 4600, "snippet" : true }, { "otype" : "Keyword", "mtid" : 4608, "link" : "/api/keyword/4608", "label" : "controlled study", "published" : true, "oldId" : 4608, "snippet" : true }, { "otype" : "Keyword", "mtid" : 5079, "link" : "/api/keyword/5079", "label" : "nonhuman", "published" : true, "oldId" : 5079, "snippet" : true }, { "otype" : "Keyword", "mtid" : 5087, "link" : "/api/keyword/5087", "label" : "animal experiment", "published" : true, "oldId" : 5087, "snippet" : true }, { "otype" : "Keyword", "mtid" : 5088, "link" : "/api/keyword/5088", "label" : "animal cell", "published" : true, "oldId" : 5088, "snippet" : true }, { "otype" : "Keyword", "mtid" : 6815, "link" : "/api/keyword/6815", "label" : "alcohol consumption", "published" : true, "oldId" : 6815, "snippet" : true }, { "otype" : "Keyword", "mtid" : 11200, "link" : "/api/keyword/11200", "label" : "Ghrelin", "published" : true, "oldId" : 11200, "snippet" : true }, { "otype" : "Keyword", "mtid" : 15057, "link" : "/api/keyword/15057", "label" : "protein targeting", "published" : true, "oldId" : 15057, "snippet" : true }, { "otype" : "Keyword", "mtid" : 19615, "link" : "/api/keyword/19615", "label" : "fatty acid transport", "published" : true, "oldId" : 19615, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1006728, "link" : "/api/keyword/1006728", "label" : "brain function", "published" : true, "oldId" : 1006728, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1009520, "link" : "/api/keyword/1009520", "label" : "carnitine", "published" : true, "oldId" : 1009520, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1020361, "link" : "/api/keyword/1020361", "label" : "cannabinoid 1 receptor", "published" : true, "oldId" : 1020361, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1029787, "link" : "/api/keyword/1029787", "label" : "drinking behavior", "published" : true, "oldId" : 1029787, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1069733, "link" : "/api/keyword/1069733", "label" : "gastrointestinal tract function", "published" : true, "oldId" : 1069733, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1107870, "link" : "/api/keyword/1107870", "label" : "fatty acid oxidation", "published" : true, "oldId" : 1107870, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1486770, "link" : "/api/keyword/1486770", "label" : "ghrelin receptor", "published" : true, "oldId" : 1486770, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1743642, "link" : "/api/keyword/1743642", "label" : "palmitoylcarnitine", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2019, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2023-02-14", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 8, "citedCount" : 8, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10985155, "link" : "/api/sjrrating/10985155", "label" : "sjr:D1 (2019) Scopus - Cell Biology CELL METABOLISM 1550-4131", "listPos" : 7, "rankValue" : 0.1, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 1307, "link" : "/api/classificationexternal/1307", "label" : "Scopus - Cell Biology", "published" : true, "oldId" : 1307, "snippet" : true }, "ranking" : "D1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "D1", "referenceList" : "Alen, F., Crespo, I., Ramírez-López, M.T., Jagerovic, N., Goya, P., de Fonseca, F.R., de Heras, R.G., Orio, L., Ghrelin-induced orexigenic effect in rats depends on the metabolic status and is counteracted by peripheral CB1 receptor antagonism (2013) PLoS ONE, 8, p. e60918 ;\n Aquila, S., Guido, C., Santoro, A., Gazzerro, P., Laezza, C., Baffa, M.F., Andò, S., Bifulco, M., Rimonabant (SR141716) induces metabolism and acquisition of fertilizing ability in human sperm (2010) Br. J. Pharmacol., 159, pp. 831-841 ;\n Arnold, M., Mura, A., Langhans, W., Geary, N., Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat (2006) J. Neurosci., 26, pp. 11052-11060 ;\n Bando, M., Iwakura, H., Koyama, H., Hosoda, H., Shigematsu, Y., Ariyasu, H., Akamizu, T., Nakao, K., High incorporation of long-chain fatty acids contributes to the efficient production of acylated ghrelin in ghrelin-producing cells (2016) FEBS Lett., 590, pp. 992-1001 ;\n Banks, W.A., Tschöp, M., Robinson, S.M., Heiman, M.L., Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure (2002) J. Pharmacol. Exp. Ther., 302, pp. 822-827 ;\n Bellocchio, L., Soria-Gómez, E., Quarta, C., Metna-Laurent, M., Cardinal, P., Binder, E., Cannich, A., Martín-Fontecha, M., Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB1 receptor blockade (2013) Proc. Natl. Acad. Sci. USA, 110, pp. 4786-4791 ;\n Bhattacharya, S.K., Andrews, K., Beveridge, R., Cameron, K.O., Chen, C., Dunn, M., Fernando, D., Jackson, V.M., Discovery of PF-5190457, a potent, selective, and orally bioavailable ghrelin receptor inverse agonist clinical candidate (2014) ACS Med. Chem. Lett., 5, pp. 474-479 ;\n Breit, S., Kupferberg, A., Rogler, G., Hasler, G., Vagus nerve as modulator of the brain-gut axis in psychiatric and inflammatory disorders (2018) Front. Psychiatry, 9, p. 44 ;\n Burdyga, G., Varro, A., Dimaline, R., Thompson, D.G., Dockray, G.J., Ghrelin receptors in rat and human nodose ganglia: putative role in regulating CB-1 and MCH receptor abundance (2006) Am. J. Physiol. Gastrointest. Liver Physiol., 290, pp. G1289-G1297 ;\n Callaghan, B., Furness, J.B., Novel and conventional receptors for ghrelin, desacyl-ghrelin, and pharmacologically related compounds (2014) Pharmacol. Rev., 66, pp. 984-1001 ;\n Cani, P.D., Montoya, M.L., Neyrinck, A.M., Delzenne, N.M., Lambert, D.M., Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716A (rimonabant) and oleoylethanolamide (2004) Br. J. Nutr., 92, pp. 757-761 ;\n Chorvat, R.J., Berbaum, J., Seriacki, K., McElroy, J.F., JD-5006 and JD-5037: peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities (2012) Bioorg. Med. Chem. Lett., 22, pp. 6173-6180 ;\n Christinat, N., Morin-Rivron, D., Masoodi, M., High-throughput quantitative lipidomics analysis of nonesterified fatty acids in human plasma (2016) J. Proteome Res., 15, pp. 2228-2235 ;\n Cinar, R., Godlewski, G., Liu, J., Tam, J., Jourdan, T., Mukhopadhyay, B., Harvey-White, J., Kunos, G., Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasing de novo synthesis of long-chain ceramides (2014) Hepatology, 59, pp. 143-153 ;\n Clegg, D.J., Brown, L.M., Zigman, J.M., Kemp, C.J., Strader, A.D., Benoit, S.C., Woods, S.C., Geary, N., Estradiol-dependent decrease in the orexigenic potency of ghrelin in female rats (2007) Diabetes, 56, pp. 1051-1058 ;\n Colombo, G., Serra, S., Vacca, G., Carai, M.A., Gessa, G.L., Endocannabinoid system and alcohol addiction: pharmacological studies (2005) Pharmacol. Biochem. Behav., 81, pp. 369-380 ;\n Date, Y., Murakami, N., Toshinai, K., Matsukura, S., Niijima, A., Matsuo, H., Kangawa, K., Nakazato, M., The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats (2002) Gastroenterology, 123, pp. 1120-1128 ;\n Date, Y., Toshinai, K., Koda, S., Miyazato, M., Shimbara, T., Tsuruta, T., Niijima, A., Nakazato, M., Peripheral interaction of ghrelin with cholecystokinin on feeding regulation (2005) Endocrinology, 146, pp. 3518-3525 ;\n Di Marzo, V., Goparaju, S.K., Wang, L., Liu, J., Bátkai, S., Járai, Z., Fezza, F., Kunos, G., Leptin-regulated endocannabinoids are involved in maintaining food intake (2001) Nature, 410, pp. 822-825 ;\n DiPatrizio, N.V., Simansky, K.J., Activating parabrachial cannabinoid CB1 receptors selectively stimulates feeding of palatable foods in rats (2008) J. Neurosci., 28, pp. 9702-9709 ;\n DiPatrizio, N.V., Astarita, G., Schwartz, G., Li, X., Piomelli, D., Endocannabinoid signal in the gut controls dietary fat intake (2011) Proc. Natl. Acad. Sci. USA, 108, pp. 12904-12908 ;\n Engelstoft, M.S., Park, W.M., Sakata, I., Kristensen, L.V., Husted, A.S., Osborne-Lawrence, S., Piper, P.K., Nøhr, M.K., Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells (2013) Mol. Metab., 2, pp. 376-392 ;\n Erlanson-Albertsson, C., Lindqvist, A., Vagotomy and accompanying pyloroplasty down-regulates ghrelin mRNA but does not affect ghrelin secretion (2008) Regul. Pept., 151, pp. 14-18 ;\n Gautron, L., Sakata, I., Udit, S., Zigman, J.M., Wood, J.N., Elmquist, J.K., Genetic tracing of Nav1.8-expressing vagal afferents in the mouse (2011) J. Comp. Neurol., 519, pp. 3085-3101 ;\n Geary, N., Wolfe, A., Polidori, C., Policani, F., Massi, M., Exogeneous and endogenous CCK inhibit ethanol ingestion in Sardinian alcohol-preferring rats (2004) Peptides, 25, pp. 1185-1194 ;\n Gilpin, N.W., Koob, G.F., Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats (2010) Psychopharmacology (Berl.), 212, pp. 431-439 ;\n Gómez, R., Navarro, M., Ferrer, B., Trigo, J.M., Bilbao, A., Del Arco, I., Cippitelli, A., Rodríguez de Fonseca, F., A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding (2002) J. Neurosci., 22, pp. 9612-9617 ;\n Gomez, J.L., Cunningham, C.L., Finn, D.A., Young, E.A., Helpenstell, L.K., Schuette, L.M., Fidler, T.L., Ryabinin, A.E., Differential effects of ghrelin antagonists on alcohol drinking and reinforcement in mouse and rat models of alcohol dependence (2015) Neuropharmacology, 97, pp. 182-193 ;\n Gómez del Pulgar, T., Velasco, G., Sánchez, C., Haro, A., Guzmán, M., De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis (2002) Biochem. J., 363, pp. 183-188 ;\n Hajnal, A., Zharikov, A., Polston, J.E., Fields, M.R., Tomasko, J., Rogers, A.M., Volkow, N.D., Thanos, P.K., Alcohol reward is increased after Roux-en-Y gastric bypass in dietary obese rats with differential effects following ghrelin antagonism (2012) PLoS ONE, 7, p. e49121 ;\n Han, W., Tellez, L.A., Perkins, M.H., Perez, I.O., Qu, T., Ferreira, J., Ferreira, T.L., Gao, X.B., A neural circuit for gut-induced reward (2018) Cell, 175, pp. 887-888 ;\n Hering, D., Kucharska, W., Kara, T., Somers, V.K., Narkiewicz, K., Potentiated sympathetic and hemodynamic responses to alcohol in hypertensive vs. normotensive individuals (2011) J. Hypertens., 29, pp. 537-541 ;\n Hjorth, S., Karlsson, C., Jucaite, A., Varnäs, K., Wählby Hamrén, U., Johnström, P., Gulyás, B., Farde, L., A PET study comparing receptor occupancy by five selective cannabinoid 1 receptor antagonists in non-human primates (2016) Neuropharmacology, 101, pp. 519-530 ;\n Hungund, B.L., Szakall, I., Adam, A., Basavarajappa, B.S., Vadasz, C., Cannabinoid CB1 receptor knockout mice exhibit markedly reduced voluntary alcohol consumption and lack alcohol-induced dopamine release in the nucleus accumbens (2003) J. Neurochem., 84, pp. 698-704 ;\n Iwakura, H., Li, Y., Ariyasu, H., Hosoda, H., Kanamoto, N., Bando, M., Yamada, G., Akamizu, T., Establishment of a novel ghrelin-producing cell line (2010) Endocrinology, 151, pp. 2940-2945 ;\n Jancsó, G., Kiraly, E., Jancsó-Gábor, A., Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones (1977) Nature, 270, pp. 741-743 ;\n Jbilo, O., Ravinet-Trillou, C., Arnone, M., Buisson, I., Bribes, E., Péleraux, A., Pénarier, G., Casellas, P., The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balance (2005) FASEB J., 19, pp. 1567-1569 ;\n Jerlhag, E., Egecioglu, E., Landgren, S., Salomé, N., Heilig, M., Moechars, D., Datta, R., Engel, J.A., Requirement of central ghrelin signaling for alcohol reward (2009) Proc. Natl. Acad. Sci. USA, 106, pp. 11318-11323 ;\n Jerlhag, E., Ivanoff, L., Vater, A., Engel, J.A., Peripherally circulating ghrelin does not mediate alcohol-induced reward and alcohol intake in rodents (2014) Alcohol. Clin. Exp. Res., 38, pp. 959-968 ;\n Kaelberer, M.M., Buchanan, K.L., Klein, M.E., Barth, B.B., Montoya, M.M., Shen, X., Bohórquez, D.V., A gut-brain neural circuit for nutrient sensory transduction (2018) Science, 361, p. eaat5236 ;\n Kirchner, H., Gutierrez, J.A., Solenberg, P.J., Pfluger, P.T., Czyzyk, T.A., Willency, J.A., Schürmann, A., Hale, J.E., GOAT links dietary lipids with the endocrine control of energy balance (2009) Nat. Med., 15, pp. 741-745 ;\n Kola, B., Hubina, E., Tucci, S.A., Kirkham, T.C., Garcia, E.A., Mitchell, S.E., Williams, L.M., Korbonits, M., Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase (2005) J. Biol. Chem., 280, pp. 25196-25201 ;\n Kola, B., Farkas, I., Christ-Crain, M., Wittmann, G., Lolli, F., Amin, F., Harvey-White, J., Grossman, A.B., The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system (2008) PLoS ONE, 3, p. e1797 ;\n Kong, J., Chuddy, J., Stock, I.A., Loria, P.M., Straub, S.V., Vage, C., Cameron, K.O., McClure, K.F., Pharmacological characterization of the first in class clinical candidate PF-05190457: a selective ghrelin receptor competitive antagonist with inverse agonism that increases vagal afferent firing and glucose-dependent insulin secretion ex vivo (2016) Br. J. Pharmacol., 173, pp. 1452-1464 ;\n Kopin, A.S., Mathes, W.F., McBride, E.W., Nguyen, M., Al-Haider, W., Schmitz, F., Bonner-Weir, S., Beinborn, M., The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight (1999) J. Clin. Invest., 103, pp. 383-391 ;\n Koyama, H., Iwakura, H., Dote, K., Bando, M., Hosoda, H., Ariyasu, H., Kusakabe, T., Akamizu, T., Comprehensive profiling of GPCR expression in ghrelin-producing cells (2016) Endocrinology, 157, pp. 692-704 ;\n le Roux, C.W., Neary, N.M., Halsey, T.J., Small, C.J., Martinez-Isla, A.M., Ghatei, M.A., Theodorou, N.A., Bloom, S.R., Ghrelin does not stimulate food intake in patients with surgical procedures involving vagotomy (2005) J. Clin. Endocrinol. Metab., 90, pp. 4521-4524 ;\n Lee, M.R., Tapocik, J.D., Ghareeb, M., Schwandt, M.L., Dias, A.A., Le, A.N., Cobbina, E., Farokhnia, M., The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: preclinical safety experiments and a phase 1b human laboratory study (2018) Mol. Psychiatry, , https://www.nature.com/articles/s41380-018-0064-y ;\n Leggio, L., Zywiak, W.H., Fricchione, S.R., Edwards, S.M., de la Monte, S.M., Swift, R.M., Kenna, G.A., Intravenous ghrelin administration increases alcohol craving in alcohol-dependent heavy drinkers: a preliminary investigation (2014) Biol. Psychiatry, 76, pp. 734-741 ;\n Li, Z., Schmidt, S.F., Friedman, J.M., Developmental role for endocannabinoid signaling in regulating glucose metabolism and growth (2013) Diabetes, 62, pp. 2359-2367 ;\n Lim, C.T., Kola, B., Feltrin, D., Perez-Tilve, D., Tschöp, M.H., Grossman, A.B., Korbonits, M., Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism (2013) Mol. Cell. Endocrinol., 365, pp. 303-308 ;\n Long, J.Z., Nomura, D.K., Vann, R.E., Walentiny, D.M., Booker, L., Jin, X., Burston, J.J., Cravatt, B.F., Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo (2009) Proc. Natl. Acad. Sci. USA, 106, pp. 20270-20275 ;\n Maccioni, P., Colombo, G., Carai, M.A., Blockade of the cannabinoid CB1 receptor and alcohol dependence: preclinical evidence and preliminary clinical data (2010) CNS Neurol. Disord. Drug Targets, 9, pp. 55-59 ;\n (2015), Martinez-Grau, M.A. (2015). Substituted piperidyl-ethyl-pyrimidineas ghrelin-o-acyl transferase inhibitor. US Patent Application, filed November 6, 2014, and published May 21 ;\n Mukhopadhyay, B., Cinar, R., Yin, S., Liu, J., Tam, J., Godlewski, G., Harvey-White, J., Lotersztajn, S., Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver (2011) Proc. Natl. Acad. Sci. USA, 108, pp. 6323-6328 ;\n Niki, M., Jyotaki, M., Yoshida, R., Yasumatsu, K., Shigemura, N., DiPatrizio, N.V., Piomelli, D., Ninomiya, Y., Modulation of sweet taste sensitivities by endogenous leptin and endocannabinoids in mice (2015) J. Physiol., 593, pp. 2527-2545 ;\n Perwitz, N., Wenzel, J., Wagner, I., Büning, J., Drenckhan, M., Zarse, K., Ristow, M., Klein, J., Cannabinoid type 1 receptor blockade induces transdifferentiation towards a brown fat phenotype in white adipocytes (2010) Diabetes Obes. Metab., 12, pp. 158-166 ;\n Ravinet Trillou, C., Delgorge, C., Menet, C., Arnone, M., Soubrié, P., CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity (2004) Int. J. Obes. Relat. Metab. Disord., 28, pp. 640-648 ;\n Rhodes, J.S., Best, K., Belknap, J.K., Finn, D.A., Crabbe, J.C., Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice (2005) Physiol. Behav., 84, pp. 53-63 ;\n Sakurazawa, N., Mano-Otagiri, A., Nemoto, T., Shibasaki, T., Effects of intracerebroventricular ghrelin on food intake and Fos expression in the arcuate nucleus of the hypothalamus in female rats vary with estrous cycle phase (2013) Neurosci. Lett., 541, pp. 204-208 ;\n Schwartz, G.J., Moran, T.H., White, W.O., Ladenheim, E.E., Relationships between gastric motility and gastric vagal afferent responses to CCK and GRP in rats differ (1997) Am. J. Physiol., 272, pp. R1726-R1733 ;\n Senin, L.L., Al-Massadi, O., Folgueira, C., Castelao, C., Pardo, M., Barja-Fernandez, S., Roca-Rivada, A., Garcia-Caballero, T., The gastric CB1 receptor modulates ghrelin production through the mTOR pathway to regulate food intake (2013) PLoS ONE, 8, p. e80339 ;\n Shimizu, T., Fujita, S., Izumi, K., Koja, T., Ohba, N., Fukuda, T., Corneal lesions induced by the systemic administration of capsaicin in neonatal mice and rats (1984) Naunyn Schmiedebergs Arch. Pharmacol., 326, pp. 347-351 ;\n Shrestha, R., Hui, S.P., Imai, H., Hashimoto, S., Uemura, N., Takeda, S., Fuda, H., Chiba, H., Plasma capric acid concentrations in healthy subjects determined by high-performance liquid chromatography (2015) Ann. Clin. Biochem., 52, pp. 588-596 ;\n Sirohi, S., Richardson, B.D., Lugo, J.M., Rossi, D.J., Davis, J.F., Impact of Roux-en-Y gastric bypass surgery on appetite, alcohol intake behaviors, and midbrain ghrelin signaling in the rat (2017) Obesity (Silver Spring), 25, pp. 1228-1236 ;\n Solinas, M., Goldberg, S.R., Piomelli, D., The endocannabinoid system in brain reward processes (2008) Br. J. Pharmacol., 154, pp. 369-383 ;\n Sun, Y., Ahmed, S., Smith, R.G., Deletion of ghrelin impairs neither growth nor appetite (2003) Mol. Cell. Biol., 23, pp. 7973-7981 ;\n Sun, Y., Wang, P., Zheng, H., Smith, R.G., Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor (2004) Proc. Natl. Acad. Sci. USA, 101, pp. 4679-4684 ;\n Tam, J., Vemuri, V.K., Liu, J., Bátkai, S., Mukhopadhyay, B., Godlewski, G., Osei-Hyiaman, D., Pickel, J., Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity (2010) J. Clin. Invest., 120, pp. 2953-2966 ;\n Tam, J., Cinar, R., Liu, J., Godlewski, G., Wesley, D., Jourdan, T., Szanda, G., Liow, J.S., Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance (2012) Cell Metab., 16, pp. 167-179 ;\n Udi, S., Hinden, L., Earley, B., Drori, A., Reuveni, N., Hadar, R., Cinar, R., Tam, J., Proximal tubular cannabinoid-1 receptor regulates obesity-induced CKD (2017) J. Am. Soc. Nephrol., 28, pp. 3518-3532 ;\n Wang, L., Liu, J., Harvey-White, J., Zimmer, A., Kunos, G., Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 1393-1398 ;\n Wang, F., Flanagan, J., Su, N., Wang, L.C., Bui, S., Nielson, A., Wu, X., Luo, Y., RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues (2012) J. Mol. Diagn., 14, pp. 22-29 ;\n Wittekind, D.A., Kratzsch, J., Mergl, R., Enzenbach, C., Witte, A.V., Villringer, A., Kluge, M., Alcohol consumption is positively associated with fasting serum ghrelin in non-dependent adults: Results from the population-based LIFE-Adult-Study (2018) Psychoneuroendocrinology, 97, pp. 143-148 ;\n Yang, J., Brown, M.S., Liang, G., Grishin, N.V., Goldstein, J.L., Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone (2008) Cell, 132, pp. 387-396 ;\n Zallar, L.J., Beurmann, S., Tunstall, B.J., Fraser, C.M., Koob, G.F., Vendruscolo, L.F., Leggio, L., Ghrelin receptor deletion reduces binge-like alcohol drinking in rats (2018) J. Neuroendocrinol. ;\n Zhao, T.J., Sakata, I., Li, R.L., Liang, G., Richardson, J.A., Brown, M.S., Goldstein, J.L., Zigman, J.M., Ghrelin secretion stimulated by beta1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice (2010) Proc. Natl. Acad. Sci. USA, 107, pp. 15868-15873 ;\n Zigman, J.M., Jones, J.E., Lee, C.E., Saper, C.B., Elmquist, J.K., Expression of ghrelin receptor mRNA in the rat and the mouse brain (2006) J. Comp. Neurol., 494, pp. 528-548 ;\n Zimmer, A., Zimmer, A.M., Hohmann, A.G., Herkenham, M., Bonner, T.I., Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice (1999) Proc. Natl. Acad. Sci. USA, 96, pp. 5780-5785", "hasCitationDuplums" : false, "userChangeableUntil" : "2019-10-27T10:48:48.368+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 10, "ownerInstituteCount" : 42, "directInstituteCount" : 0, "authorCount" : 14, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/30748558", "label" : "Godlewski G. et al. Targeting Peripheral CB1 Receptors Reduces Ethanol Intake via a Gut-Brain Axis. (2019) CELL METABOLISM 1550-4131 1932-7420 29 6 1320-1333.e8", "template" : "