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      <abstractText>OBJECTIVE: Hypertension causes adverse remodeling and vasomotor alterations in coronaries. Hormones such as estrogen may help counterbalance some of these effects. The aim of this study was to analyze the effects of ovariectomy and estrogen therapy in a rat model of menopausal hypertension induced by angiotensin II (AII). METHODS: We investigated diameter, tone, and mechanics of intramural coronaries taken from ovariectomized female rats (n = 11) that received chronic AII treatment to induce hypertension, and compared the results with those found in female rats that were also given estrogen therapy (n = 11). The "hypertensive control" group (n = 11) underwent an abdominal sham operation, and received AII. After 4 weeks of AII treatment, side branches of left anterior descendent coronary (approximately 200 mum in diameter) were isolated, cannulated with plastic microcannulas at both ends, and studied in vitro in a vessel chamber. The inner and outer diameter of the arteries were measured by microangiometry, and spontenuous tone, wall thickness, wall cross-sectional area, tangential stress, incremental distensibility, circumferential incremental elastic modulus, thromboxane agonist-induced tone, and bradykinin-induced dilation were calculated. RESULTS: In hypertension, intramural small coronaries show inward eutrophic remodeling after ovariectomy comparing with hypertensive controls. Estrogen therapy had an opposite effect on vessel diameter. Hormone therapy led to an increase in spontaneous tone, allowing for greater dilatative capacity. CONCLUSIONS: Estrogen may therefore be considered to counterbalance some of the adverse changes seen in the wall of intramural coronaries in the early stages of chronic hypertension.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0.</abstractText>
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		&lt;div class=&quot;autype autype0&quot;&gt;				&lt;span class=&quot;author-name&quot; mtid=&quot;10084383&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10084383&quot; target=&quot;_blank&quot;&gt;Matrai M
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Mátrai Máté&lt;/span&gt;
	            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Szülészet-nőgyógyászat, keringésélettan&lt;/span&gt;)
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/Klinikai Kísérleti Kutató- és Humán Élettani Intézet&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10053136&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10053136&quot; target=&quot;_blank&quot;&gt;Hetthessy JR&lt;sup&gt;*&lt;/sup&gt; ✉
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Hetthéssy Judit&lt;/span&gt;
	            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Ortopédia&lt;/span&gt;)
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/Ortopédiai Klinika&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10023262&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10023262&quot; target=&quot;_blank&quot;&gt;Nadasy GL
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Nádasy György László&lt;/span&gt;
	            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Keringésélettan&lt;/span&gt;)
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/Élettani Intézet&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10010752&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10010752&quot; target=&quot;_blank&quot;&gt;Szekacs B
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Székács Béla&lt;/span&gt;
	            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Belgyógyászat&lt;/span&gt;)
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/&lt;span title=&quot;II. Sz. Belgyógyászati Klinika&quot;&gt;IISZBK&lt;/span&gt;/II. Sz. Belgyógyászati Klinika Geriátriai Tanszéki Csoport&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; &gt;Mericli M
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;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10013998&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10013998&quot; target=&quot;_blank&quot;&gt;Acs N
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Ács Nándor&lt;/span&gt;
	            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Szülészet-nőgyógyászat&lt;/span&gt;)
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/II. Sz. Szülészeti és Nőgyógyászati Klinika&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10009471&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10009471&quot; target=&quot;_blank&quot;&gt;Monos E
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Monos Emil&lt;/span&gt;
	            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Fiziológia&lt;/span&gt;)
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Klinikai Kísérleti Kutató Intézet&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; &gt;Arbib N
    &lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10011316&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10011316&quot; target=&quot;_blank&quot;&gt;Varbiro S
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Várbíró Szabolcs&lt;/span&gt;
	            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Keringésélettan&lt;/span&gt;)
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/II. Sz. Szülészeti és Nőgyógyászati Klinika&lt;/span&gt;

				    &lt;/div&gt;
&lt;/div&gt;
&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;3073859&quot; target=&quot;_blank&quot;&gt;Estrogen therapy may counterbalance eutrophic remodeling of coronary arteries and increase bradykinin relaxation in a rat model of menopausal hypertension.&lt;/a&gt;&lt;/div&gt;    &lt;div&gt;		&lt;span class=&quot;journal-title&quot;&gt;MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY&lt;/span&gt;

        &lt;span class=&quot;journal-issn&quot;&gt;(&lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/1072-3714&quot;&gt;1072-3714&lt;/a&gt; &lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/1530-0374&quot;&gt;1530-0374&lt;/a&gt;)&lt;/span&gt;:
		&lt;span class=&quot;journal-volume&quot;&gt;23&lt;/span&gt; &lt;span class=&quot;journal-issue&quot;&gt;7&lt;/span&gt;
&lt;span class=&quot;page&quot;&gt;
	pp 778-783
			
&lt;/span&gt;		 &lt;span class=&quot;year&quot;&gt;(2016)&lt;/span&gt;  
    &lt;/div&gt;
&lt;div class=&quot;pub-footer&quot;&gt;
    

	&lt;span class=&quot;language&quot; xmlns=&quot;http://www.w3.org/1999/html&quot;&gt;Nyelv:
			Angol
		 |  &lt;/span&gt;

	&lt;span class=&quot;identifiers&quot;&gt;
						&lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt;
							
							&lt;a style=&quot;color:blue&quot; title=&quot;10.1097/GME.0000000000000654&quot; target=&quot;_blank&quot; href=&quot;https://doi.org/10.1097/GME.0000000000000654&quot;&gt;
									DOI
							&lt;/a&gt;
						&lt;/span&gt;
						&lt;span class=&quot;id identifier oa_GREEN&quot; title=&quot;	Green
&quot;&gt;
							
							&lt;a style=&quot;color:blue&quot; title=&quot;4822&quot; target=&quot;_blank&quot; href=&quot;https://repo.lib.semmelweis.hu/handle/123456789/4822&quot;&gt;
									SE Repozitórium
							&lt;/a&gt;
						&lt;/span&gt;
						&lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt;
							
							&lt;a style=&quot;color:blue&quot; title=&quot;000379370600012&quot; target=&quot;_blank&quot; href=&quot;https://www.webofscience.com/wos/woscc/full-record/000379370600012&quot;&gt;
									WoS
							&lt;/a&gt;
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						&lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt;
							
							&lt;a style=&quot;color:blue&quot; title=&quot;84969278881&quot; target=&quot;_blank&quot; href=&quot;http://www.scopus.com/record/display.url?origin=inward&amp;eid=2-s2.0-84969278881&quot;&gt;
									Scopus
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						&lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt;
							
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									PubMed
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						&lt;span class=&quot;id identifier oa_GREEN&quot; title=&quot;	Green
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									Pubmed Central
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	&lt;OnlyViewableByAuthor&gt;&lt;div class=&quot;ratings&quot;&gt;
				&lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Obstetrics and Gynecology&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;Q1&lt;/div&gt;
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		&lt;span title=&quot;Nyilvános idézőközlemények összesen, említések nélkül&quot; class=&quot;citingPub-count&quot;&gt;Nyilvános idéző összesen: 9&lt;/span&gt;
		| Független: 6
		| Függő: 3
		| Nem jelölt: 0
		| WoS jelölt: 8 
		|  Scopus jelölt:&amp;nbsp;8 
		|  WoS/Scopus jelölt:&amp;nbsp;8 
		|  DOI jelölt:&amp;nbsp;9 
		
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    &lt;div class=&quot;mtid&quot;&gt;&lt;span class=&quot;long-pub-mtid&quot;&gt;Közlemény: 3073859&lt;/span&gt;
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	&lt;span class=&quot;oldId&quot;&gt;Régi azonosító: 3073859&lt;/span&gt; | 
	
Forrás	 Idéző
	
	
    | &lt;span class=&quot;type-subtype&quot;&gt;Folyóiratcikk
			( Szakcikk
			
			)
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      		| &lt;span class=&quot;pub-category&quot;&gt;Tudományos&lt;/span&gt;
	| &lt;span class=&quot;publication-sourceOfData&quot;&gt;MEDLINE&lt;/span&gt;
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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2022.10.10. 15:01 Vasvari Lilian (MTMT Központ, admin)
&lt;/div&gt;


        &lt;div class=&quot;lockedBy&quot;&gt;Központi kezelésű 2019.08.27. 10:10  Aggod Zsuzsa (MTMT 2-3, admin)
        &lt;/div&gt;


	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: M.M. and J.R.H. contributed equally to this work.&lt;/pre&gt;
&lt;/div&gt;&lt;/div&gt;</template2>
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