{ "labelLang" : "hun", "responseDate" : "2024-03-28 14:16", "content" : { "otype" : "JournalArticle", "mtid" : 30725709, "status" : "VALIDATED", "published" : true, "comment" : "Department of Psychiatry, University of Oxford, Oxford, United Kingdom \n IMED Neuroscience, AstraZeneca UK Ltd, Cambridge, Cambridgeshire, United Kingdom \n Invicro, London, United Kingdom \n Department of Medicine, Imperial College London, London, United Kingdom \n Department of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom \n Department of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom \n Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom \n Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom \n MRC Cognition and Brain Sciences Unit, Cambridge, Cambridgeshire, United Kingdom \n MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom \n Department of Neurology, Imperial College London Faculty of Medicine, London, United Kingdom \n Medical School, University of Exeter, Exeter, United Kingdom \n Department of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom \n Manchester Academic Health Sciences Centre, Institute of Brain, Behaviour and Mental Health, Manchester, United Kingdom \n Queen's University Belfast, Belfast, United Kingdom \n Alzheimer's Society, London, London, United Kingdom \n Leonard Wolfson Experimental Neurology Centre, University College London Institute of Neurology, London, London, United Kingdom \n Export Date: 3 September 2019 \n Correspondence Address: Lovestone, S.; Department of Psychiatry, University of OxfordUnited Kingdom; email: simon.lovestone@psych.ox.ac.uk\nDepartment of Psychiatry, University of Oxford, Oxford, United Kingdom \n IMED Neuroscience, AstraZeneca UK Ltd, Cambridge, Cambridgeshire, United Kingdom \n Invicro, London, United Kingdom \n Department of Medicine, Imperial College London, London, United Kingdom \n Department of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom \n Department of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom \n Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom \n Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom \n MRC Cognition and Brain Sciences Unit, Cambridge, Cambridgeshire, United Kingdom \n MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom \n Department of Neurology, Imperial College London Faculty of Medicine, London, United Kingdom \n Medical School, University of Exeter, Exeter, United Kingdom \n Department of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom \n Manchester Academic Health Sciences Centre, Institute of Brain, Behaviour and Mental Health, Manchester, United Kingdom \n Queen's University Belfast, Belfast, United Kingdom \n Alzheimer's Society, London, London, United Kingdom \n Leonard Wolfson Experimental Neurology Centre, University College London Institute of Neurology, London, London, United Kingdom \n Cited By :1 \n Export Date: 5 November 2020 \n Correspondence Address: Lovestone, S.; Department of Psychiatry, University of OxfordUnited Kingdom; email: simon.lovestone@psych.ox.ac.uk\nFunding Agency and Grant Number: National Institute for Health Research (NIHR)National Institute for Health Research (NIHR) [MR/N029941/1]; Medical Research Council (MRC)Medical Research Council UK (MRC); NeuroVision Imaging; UCL Leonard Wolfson Experimental Neurology Centre [PR/ylr/18575]; ARUK Network Acceleration award for cross-platform harmonisation of 3T MRI protocols for dementia [ARUK-NAS2016B-2]; Wellcome TrustWellcome Trust [103838]\n Funding text: The study is funded through a grant (MR/N029941/1) from the National Institute for Health Research (NIHR) and the Medical Research Council (MRC). 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"2044-6055", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 10024941, "snippet" : true }, "volume" : "9", "issue" : "3", "internalId" : "e024498", "firstPageOrInternalIdForSort" : "e024498", "pageLength" : 16, "publishedYear" : 2019, "abstractText" : "Introduction Recent failures of potential novel therapeutics for Alzheimer's disease (AD) have prompted a drive towards clinical studies in prodromal or preclinical states. However, carrying out clinical trials in early disease stages is extremely challenging-a key reason being the unfeasibility of using classical outcome measures of dementia trials (eg, conversion to dementia) and the lack of validated surrogate measures so early in the disease process. The Deep and Frequent Phenotyping (DFP) study aims to resolve this issue by identifying a set of markers acting as indicators of disease progression in the prodromal phase of disease that could be used as indicative outcome measures in proof-of-concept trials.Methods and analysis The DFP study is a repeated measures observational study where participants will be recruited through existing parent cohorts, research interested lists/databases, advertisements and memory clinics. Repeated measures of both established (cognition, positron emission tomography (PET) imaging or cerebrospinal fluid (CSF) markers of pathology, structural MRI markers of neurodegeneration) and experimental modalities (functional MRI, magnetoencephalography and/or electroencephalography, gait measurement, ophthalmological and continuous smartphone-based cognitive and other assessments together with experimental CSF, blood, tear and saliva biomarkers) will be performed. We will be recruiting male and female participants aged >60 years with prodromal AD, defined as absence of dementia but with evidence of cognitive impairment together with AD pathology as assessed using PET imaging or CSF biomarkers. Control participants without evidence of AD pathology will be included at a 1: 4 ratio.Ethics and dissemination The study gained favourable ethical opinion from the South Central-Oxford B NHS Research Ethics Committee (REC reference 17/SC/0315; approved on 18 August 2017; amendment 13 February 2018). 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