Tyrosinase immunohistochemistry can be employed for the diagnosis of atypical teratoid/rhabdoid tumours of the tyrosinase subgroup (ATRT-TYR).

Atypical teratoid/rhabdoid tumour (ATRT) is a malignant brain tumour mainly occurring in young children [1]. Mutations of chromatin remodelling complex member SMARCB1/INI1 or (rarely) SMARCA4/BRG1 are the sole recurrent genetic lesions [2, 3]. On an epigenetic level, however, ATRT is a heterogeneous disease comprised of three different molecular subgroups (ATRT-TYR, ATRT-SHH and ATRT-MYC). This article is protected by copyright. All rights reserved.