Aminocarbonylation of aryl halides, homogeneously catalysed by palladium, is an efficient
method that can be employed for obtaining amides for pharmaceutical and synthetic
applications.In this work, palladium (II) complexes containing P<^>N ligands were
studied as catalysts in the aminocarbonylation of iodobenzene in the presence of diethylamine.
Two types of systems were used: a palladium (II) complex formed in situ; and one prepared
prior to the catalytic reaction. In general, the palladium complexes studied achieved
high conversions in an average reaction time of less than 2 hr, which is less than
that for the standard system (Pd (II)/PPh3) used. The pre-synthesized complexes were
faster than their in situ counterparts, as the latter require an induction time to
form the Pd/P<^>N species. The structure and electronic properties of the ligand P<^>N
can influence both the activity and the selectivity of the reaction, stabilizing the
acyl-palladium intermediates formed in a better manner.