Changes in Theta and Gamma Network Oscillations during the Development of Neurodegenerative Disorders

Kichigina, V. F.

English Scientific Survey paper (Journal Article)
Published: SOVREMENNYE TEHNOLOGII V MEDICINE 2076-4243 11 (1) pp. 16-28 2019
  • SJR Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous): Q3
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    Theta and gamma oscillations registered in the hippocampus and neocortex are necessary for cognitive processes in the brain; their alterations are revealed in many neurological and psychiatric diseases. The most common forms of neurodegenerative disorders, Alzheimer's disease (AD) and temporal lobe epilepsy (TLE) are characterized by the loss of cells and progressive violations of cognitive functions, such as memory. Early diagnosis of diseases is very important for their successful treatment. Many efforts have been done for defining early signs of these diseases. Significant advances have been made in the searching of some AD and TLE reliable biomarkers with using biochemical and imaging approaches. However, there is a great need for the biomarkers that would reflect changes of brain activity within few milliseconds to obtain information about cognitive disturbances.In the present review, the data of recent literature specifying that the coherent analysis of the theta and gamma oscillations can be used in early diagnostics of TLE and AD are considered. These data show that in a brain with the developing neurodegenerative disorder the specific violations of the theta and gamma interaction are observed. We summarize here the data on the alterations of the theta and gamma coherence based on examples from TLE and AD and from models of these diseases. The specific disturbances in interactions of theta-gamma oscillations in hippocampal, hippocampal-entorhinal, hippocampal-prefrontal, and hippocampal-septal networks were revealed in the epileptic brain. In the AD models, marked changes were observed in the theta-gamma coupling in the subiculum, an output region of the hippocampus. In addition, a decreased theta-gamma interaction between the hippocampus and the parietal cortex as well as between the hippocampus and the prefrontal cortex was also shown.
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    2020-09-21 21:20