https://m2.mtmt.hu/ hun 2026-09-23 05:40 JournalArticle 30650204 VALIDATED true 0 false 2026-09-10T08:24:17.495+0000 2024-12-06T17:52:38.677+0000 2019-04-30T10:54:47.198+0000 true 10000109 Győrffy Balázs /api/author/10000109 Author true 10000109 2024-03-20T09:36:10.015+0000 2024-12-06T17:52:39.001+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Fekete, János Tibor ROCplot.org: Validating predictive biomarkers of chemotherapy/hormonal therapy/anti-HER2 therapy using transcriptomic data of 3,104 breast cancer patients true true /api/journal/2005 REVIEWED true false 2005 false 2005 true 0020-7136 1097-0215 Journal FOREIGN 145 11 3140 3151 3140 12 2019 Systemic therapy of breast cancer can include chemotherapy, hormonal therapy, and targeted therapy. Prognostic biomarkers are able to predict survival and predictive biomarkers are able to predict therapy response. In this report, we describe the initial release of the first available online tool able to identify gene expression-based predictive biomarkers using transcriptomic data of a large set of breast cancer patients. Published gene expression data of 36 publicly available datasets was integrated with treatment data into a unified database. Response to therapy was determined using either author-reported pathological complete response data (n=1,775) or relapse-free survival status at five years (n=1,329). Treatment data includes chemotherapy (n=2,108), endocrine therapy (n=971), and anti-HER2 therapy (n=267). The transcriptomic database includes 20,089 unique genes and 54,675 probe sets. Gene expression and therapy response are compared using receiver operating characteristics and Mann-Whitney tests. We demonstrate the utility of the pipeline by cross-validating 23 paclitaxel resistance-associated genes in different molecular subtypes of breast cancer. An additional set of established biomarkers including TP53 for chemotherapy in Luminal breast cancer (p=1.01e-19, AUC=0.769), HER2 for trastuzumab therapy (p=8.4e-04, AUC=0.629), and PGR for hormonal therapy (p=8.6e-05, AUC=0.7), are also endorsed. The tool is designed to validate and rank new predictive biomarker candidates in real time. By analyzing the selected genes in a large set of independent patients, one can select the most robust candidates and quickly eliminate those that are most likely to fail in a clinical setting. The analysis tool is accessible at www.rocplot.org. This article is protected by copyright. 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Gyermekgyógyászati Klinika (SE / AOK / K); Onkológiai Biomarker Kutatócsoport (Lendület) (HRN TTK / MÉI) 2 26 2 2 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 86906909 /api/authorship/86906909 1 0.5 true false Author 10063867 /api/author/10063867 Fekete János Tibor true 10063867 true Fekete János Tibor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 86906910 /api/authorship/86906910 2 0.5 false true true Author 10000109 /api/author/10000109 Győrffy Balázs true 10000109 true Győrffy Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 15574250 /api/publicationidentifier/15574250 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1002/ijc.32369 https://doi.org/10.1002/ijc.32369 false true PublicationIdentifier 15998617 /api/publicationidentifier/15998617 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000489630100023 https://www.webofscience.com/wos/woscc/full-record/000489630100023 false true PublicationIdentifier 16140977 /api/publicationidentifier/16140977 SwordSource 84 /api/publicationsource/84 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true SE Repozitórium SE Repozitórium https://repo.lib.semmelweis.hu/handle/123456789/@@@ true true 84 true GREEN true IDENTICAL 8013 https://repo.lib.semmelweis.hu/handle/123456789/8013 false true PublicationIdentifier 16140970 /api/publicationidentifier/16140970 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GREEN true 103897 https://real.mtak.hu/103897 false true PublicationIdentifier 15740760 /api/publicationidentifier/15740760 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85065501187 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85065501187 false true PublicationIdentifier 15574249 /api/publicationidentifier/15574249 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 31020993 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31020993&dopt=Abstract false true Keyword 1481 /api/keyword/1481 true 1481 true Keyword 16728 /api/keyword/16728 true 16728 true Keyword 1057596 /api/keyword/1057596 true 1057596 true Keyword 1111449 /api/keyword/1111449 true 1111449 true Keyword 1556184 /api/keyword/1556184 true true Keyword 1714794 /api/keyword/1714794 true true MtaRating 11507750 /api/mtarating/11507750 RatingType 10007 /api/ratingtype/10007 SZTB Institute 14102 /api/institute/14102 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true B nemzetközi false true SjrRating 10984585 /api/sjrrating/10984585 37 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1306 /api/classificationexternal/1306 true 1306 true Q1 DIRECT true true /api/publication/30650204 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10063867"><a href="/gui2/?type=authors&mode=browse&sel=10063867" target="_blank">Fekete János Tibor (<span class="authorship-author-name">Fekete János Tibor</span> <span class="authorAux-mtmt"> Prediktív biomarkerek</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Győrffy Balázs ✉ (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Gyermekgyógyászati Klinika; <span title="Természettudományi Kutatóközpont">TTK</span>/<span title="Enzimológiai Intézet">EI</span>/Onkológiai Biomarker Kutatócsoport (Lendület)</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30650204" target="_blank">ROCplot.org: Validating predictive biomarkers of chemotherapy/hormonal therapy/anti-HER2 therapy using transcriptomic data of 3,104 breast cancer patients</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF CANCER</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0020-7136">0020-7136</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1097-0215">1097-0215</a>)</span>: <span class="journal-volume">145</span> <span class="journal-issue">11</span> <span class="page"> pp 3140-3151 </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1002/ijc.32369" target="_blank" href="https://doi.org/10.1002/ijc.32369"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000489630100023" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000489630100023"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="8013" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/8013"> SE Repozitórium </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="103897" target="_blank" href="https://real.mtak.hu/103897"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85065501187" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85065501187"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31020993" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31020993&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 336</span> | Független: 324 | Függő: 12 | Nem jelölt: 0 | WoS jelölt: 324 | Scopus jelölt:&nbsp;314 | WoS/Scopus jelölt:&nbsp;336 | DOI jelölt:&nbsp;332 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30650204&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 30650204</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed (pubmed_result (1).xml, 2019-04-30)</span> </div> <div class="lastModified">Utolsó módosítás: 2024.12.06. 18:52 Milánkovics Róbert (PTE ÁOK admin 4) </div> </div></div>