{ "labelLang" : "hun", "responseDate" : "2024-03-28 10:23", "content" : { "otype" : "JournalArticle", "mtid" : 30644621, "status" : "VALIDATED", "published" : true, "comment" : "Laboratory of Functional Genomics, Biological Research Centre, Hungarian Academy of Sciences, Temesvári krt. 62, Szeged, H-6726, Hungary \n Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary \n Avidin Ltd., Alsó kiköt o sor 11/D, Szeged, H-6726, Hungary \n AstridBio Technologies Ltd., Alsó kiköt o sor 11/D, Szeged, H-6726, Hungary \n Department of Physiology, Anatomy and Neuroscience, Interdisciplinary Excellence Centre, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary \n Cited By :1 \n Export Date: 28 August 2019 \n CODEN: MOLEF \n Correspondence Address: Puskás, L.G.; Laboratory of Functional Genomics, Biological Research Centre, Hungarian Academy of Sciences, Temesvári krt. 62, Hungary; email: laszlo@avidinbiotech.com \n Funding details: Emberi Eroforrások Minisztériuma, UNKP-18-4-SZTE-73 \n Funding details: Magyar Tudományos Akadémia, BO/00139/17/8 \n Funding details: Office of Research, Innovation and Economic Development, California State Polytechnic University, Pomona \n Funding text 1: Funding: This research was supported by the following grants: 2018-1.3.1-VKE-2018-00018, GINOP-2.3.2-15 -2016-00030 and GINOP-2.3.2-15-2016-00001 by the National Research, Development and Innovation Office. The Ministry of Human Capacities, Hungary grant 20391-3/2018/FEKUSTRAT is acknowledged. Gábor J. Szebeni was supported by the UNKP-18-4 New National Excellence Program of the Ministry of Human Capacities (UNKP-18-4-SZTE-73) and János Bolyai by the Research Scholarship of the Hungarian Academy of Sciences (BO/00139/17/8).\nLaboratory of Functional Genomics, Biological Research Centre, Hungarian Academy of Sciences, Temesvári krt. 62, Szeged, H-6726, Hungary \n Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary \n Avidin Ltd., Alsó kiköt o sor 11/D, Szeged, H-6726, Hungary \n AstridBio Technologies Ltd., Alsó kiköt o sor 11/D, Szeged, H-6726, Hungary \n Department of Physiology, Anatomy and Neuroscience, Interdisciplinary Excellence Centre, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary \n Cited By :2 \n Export Date: 30 January 2020 \n CODEN: MOLEF \n Correspondence Address: Puskás, L.G.; Laboratory of Functional Genomics, Biological Research Centre, Hungarian Academy of Sciences, Temesvári krt. 62, Hungary; email: laszlo@avidinbiotech.com\nLaboratory of Functional Genomics, Biological Research Centre, Hungarian Academy of Sciences, Temesvári krt. 62, Szeged, H-6726, Hungary \n Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary \n Avidin Ltd., Alsó kiköt o sor 11/D, Szeged, H-6726, Hungary \n AstridBio Technologies Ltd., Alsó kiköt o sor 11/D, Szeged, H-6726, Hungary \n Department of Physiology, Anatomy and Neuroscience, Interdisciplinary Excellence Centre, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary \n Cited By :8 \n Export Date: 22 November 2020 \n CODEN: MOLEF \n Correspondence Address: Puskás, L.G.; Laboratory of Functional Genomics, Biological Research Centre, Hungarian Academy of Sciences, Temesvári krt. 62, Hungary; email: laszlo@avidinbiotech.com \n Chemicals/CAS: curcumin, 458-37-7; Anti-Inflammatory Agents; Curcumin; Interleukin-4; Interleukin-6; NF-kappa B; Tumor Necrosis Factor-alpha \n Funding details: Emberi Eroforrások Minisztériuma, EMMI, UNKP-18-4-SZTE-73 \n Funding details: Magyar Tudományos Akadémia, MTA, BO/00139/17/8 \n Funding details: National Research, Development and Innovation Office \n Funding text 1: Funding: This research was supported by the following grants: 2018-1.3.1-VKE-2018-00018, GINOP-2.3.2-15 -2016-00030 and GINOP-2.3.2-15-2016-00001 by the National Research, Development and Innovation Office. The Ministry of Human Capacities, Hungary grant 20391-3/2018/FEKUSTRAT is acknowledged. Gábor J. Szebeni was supported by the UNKP-18-4 New National Excellence Program of the Ministry of Human Capacities (UNKP-18-4-SZTE-73) and János Bolyai by the Research Scholarship of the Hungarian Academy of Sciences (BO/00139/17/8).\nLaboratory of Functional Genomics, Biological Research Centre, Hungarian Academy of Sciences, Temesvári krt. 62, Szeged, H-6726, Hungary \n Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary \n Avidin Ltd., Alsó kiköt o sor 11/D, Szeged, H-6726, Hungary \n AstridBio Technologies Ltd., Alsó kiköt o sor 11/D, Szeged, H-6726, Hungary \n Department of Physiology, Anatomy and Neuroscience, Interdisciplinary Excellence Centre, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary \n Cited By :9 \n Export Date: 10 January 2021 \n CODEN: MOLEF \n Correspondence Address: Puskás, L.G.; Laboratory of Functional Genomics, Biological Research Centre, Hungarian Academy of Sciences, Temesvári krt. 62, Hungary; email: laszlo@avidinbiotech.com \n Chemicals/CAS: curcumin, 458-37-7; Anti-Inflammatory Agents; Curcumin; Interleukin-4; Interleukin-6; NF-kappa B; Tumor Necrosis Factor-alpha \n Funding details: Emberi Eroforrások Minisztériuma, EMMI, UNKP-18-4-SZTE-73 \n Funding details: Magyar Tudományos Akadémia, MTA, BO/00139/17/8 \n Funding details: National Research, Development and Innovation Office \n Funding text 1: Funding: This research was supported by the following grants: 2018-1.3.1-VKE-2018-00018, GINOP-2.3.2-15 -2016-00030 and GINOP-2.3.2-15-2016-00001 by the National Research, Development and Innovation Office. The Ministry of Human Capacities, Hungary grant 20391-3/2018/FEKUSTRAT is acknowledged. Gábor J. Szebeni was supported by the UNKP-18-4 New National Excellence Program of the Ministry of Human Capacities (UNKP-18-4-SZTE-73) and János Bolyai by the Research Scholarship of the Hungarian Academy of Sciences (BO/00139/17/8).\nLaboratory of Functional Genomics, Biological Research Centre, Hungarian Academy of Sciences, Temesvári krt. 62, Szeged, H-6726, Hungary \n Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary \n Avidin Ltd., Alsó kiköt o sor 11/D, Szeged, H-6726, Hungary \n AstridBio Technologies Ltd., Alsó kiköt o sor 11/D, Szeged, H-6726, Hungary \n Department of Physiology, Anatomy and Neuroscience, Interdisciplinary Excellence Centre, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary \n Cited By :10 \n Export Date: 21 January 2021 \n CODEN: MOLEF \n Correspondence Address: Puskás, L.G.; Laboratory of Functional Genomics, Temesvári krt. 62, Hungary; email: laszlo@avidinbiotech.com\nLaboratory of Functional Genomics, Biological Research Centre, Hungarian Academy of Sciences, Temesvári krt. 62, Szeged, H-6726, Hungary \n Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary \n Avidin Ltd., Alsó kiköt o sor 11/D, Szeged, H-6726, Hungary \n AstridBio Technologies Ltd., Alsó kiköt o sor 11/D, Szeged, H-6726, Hungary \n Department of Physiology, Anatomy and Neuroscience, Interdisciplinary Excellence Centre, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary \n Cited By :10 \n Export Date: 10 February 2021 \n CODEN: MOLEF \n Correspondence Address: Puskás, L.G.; Laboratory of Functional Genomics, Temesvári krt. 62, Hungary; email: laszlo@avidinbiotech.com\nLaboratory of Functional Genomics, Biological Research Centre, Hungarian Academy of Sciences, Temesvári krt. 62, Szeged, H-6726, Hungary \n Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary \n Avidin Ltd., Alsó kiköt o sor 11/D, Szeged, H-6726, Hungary \n AstridBio Technologies Ltd., Alsó kiköt o sor 11/D, Szeged, H-6726, Hungary \n Department of Physiology, Anatomy and Neuroscience, Interdisciplinary Excellence Centre, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary \n Cited By :10 \n Export Date: 12 March 2021 \n CODEN: MOLEF \n Correspondence Address: Puskás, L.G.; Laboratory of Functional Genomics, Temesvári krt. 62, Hungary; email: laszlo@avidinbiotech.com \n Chemicals/CAS: curcumin, 458-37-7; Anti-Inflammatory Agents; Curcumin; Interleukin-4; Interleukin-6; NF-kappa B; Tumor Necrosis Factor-alpha \n Funding details: Magyar Tudományos Akadémia, MTA, BO/00139/17/8 \n Funding details: Emberi Eroforrások Minisztériuma, EMMI, UNKP-18-4-SZTE-73 \n Funding details: National Research, Development and Innovation Office \n Funding text 1: Funding: This research was supported by the following grants: 2018-1.3.1-VKE-2018-00018, GINOP-2.3.2-15 -2016-00030 and GINOP-2.3.2-15-2016-00001 by the National Research, Development and Innovation Office. 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Mannich curcuminoids, C142 or C150 synthetized in our laboratory, have been tested for anti-inflammatory activity in a rat model of TNBS (2,4,6-trinitrobenzenesulphonic acid) induced colitis. Treatment with C142 or C150 reduced leukocyte infiltration to the submucosa and muscular propria of the inflamed gut. C142 or C150 rescued the loss of body weight and C150 decreased the weight of standard colon preparations proportional with 20% less tissue oedema. Both C142 and C150 curcumin analogues caused 25% decrease in the severity of colonic inflammation and haemorrhagic lesion size. Colonic MPO (myeloperoxidase) enzyme activity as an indicator of intense neutrophil infiltration was 50% decreased either by C142 or C150 Mannich curcuminoids. Lipopolysaccharide (LPS) co-treatment with Mannich curcuminoids inhibited NF-B (nuclear factor kappa B) activity on a concentration-dependent manner in an NF-B-driven luciferase expressing reporter cell line. Co-treatment with LPS and curcuminoids, C142 or C150, resulted in NF-B inhibition with 3.57 M or 1.6 M half maximal effective concentration (EC50) values, respectively. C150 exerted a profound inhibition of the expression of inflammatory cytokines, tumor necrosis factor- (TNF-), interleukin-6 (IL-6), and interleukin-4 (IL-4) in human PBMCs (peripheral blood mononuclear cells) upon LPS stimulus. 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