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Gasser, ClinResearch, funded by AbbVie, and the statistical analysis was performed by Christoph Meyenberg, Koehler eClinical, funded by AbbVie.\nParkinson Foundation International Centre of Excellence, King's College Hospital, Denmark Hill, London, United Kingdom \n Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom \n Department of Neuroscience, University of Padua, Padua, Italy \n AbbVie Inc., North Chicago, IL, United States \n Medical University of Innsbruck, Innsbruck, Austria \n Cited By :5 \n Export Date: 3 February 2021 \n CODEN: EJNEF \n Correspondence Address: Ray Chaudhuri, K.; Parkinson Foundation International Centre of Excellence, Denmark Hill, United Kingdom; email: Ray.chaudhuri@kcl.ac.uk\nParkinson Foundation International Centre of Excellence, King's College Hospital, Denmark Hill, London, United Kingdom \n Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom \n Department of Neuroscience, University of Padua, Padua, Italy \n AbbVie Inc., North Chicago, IL, United States \n Medical University of Innsbruck, Innsbruck, Austria \n Cited By :9 \n Export Date: 18 May 2021 \n CODEN: EJNEF \n Correspondence Address: Ray Chaudhuri, K.; Parkinson Foundation International Centre of Excellence, Denmark Hill, United Kingdom; email: Ray.chaudhuri@kcl.ac.uk\nExport Date: 30 June 2021 \n CODEN: EJNEF", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2023-05-05T06:28:10.497+0000", "lastModified" : "2022-08-17T13:49:08.192+0000", "created" : "2019-03-18T18:16:23.084+0000", "creator" : { "otype" : "Author", "mtid" : 10000410, "link" : "/api/author/10000410", "label" : "Vécsei László (Neurológia)", "familyName" : "Vécsei", "givenName" : "László", "published" : true, "oldId" : 10000410, "snippet" : true }, "lastDuplumOK" : "2023-05-12T15:27:06.131+0000", "lastDuplumSearch" : "2023-05-12T15:27:06.131+0000", "adminApproved" : "2022-08-17T13:49:08.535+0000", "adminApprover" : { "otype" : "Admin", "mtid" : 10078753, "link" : "/api/admin/10078753", "label" : "Kiss Fatima Jázmin (SZTE admin5)", "familyName" : "Kiss", "givenName" : "Fatima Jázmin", "published" : true, "snippet" : true }, "core" : false, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Chaudhuri, K. 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clinical care, demonstrated significant reductions from baseline in 'off' time and 'on' time with dyskinesia and improvements in the Non-Motor Symptom Scale (NMSS) total and individual domain scores, and in Parkinson's Disease Questionnaire 8 item (PDQ-8) total score. Methods Associations between baseline NMSS burden (NMSB), the multi-domain NMSS total score and the PDQ-8 total score were investigated for 233 patients. Baseline NMSB was assigned to five numerical categories defined by the NMSS total cutoff scores (0-20, 21-40, 41-60, 61-80 and >80). Pearson and Spearman correlations were calculated at month 24. Results The response of LCIG was assessed using validated criteria after 24 months. The proportion of patients decreasing >= 30 NMSS score points was 47% in the most affected NMSB category (NMSS total score > 80). A positive association was noted between baseline NMSB and NMSS total score (0.57, P < 0.0001), as well as between NMSS total score and PDQ-8 total score (0.46, P < 0.0001). Associations between improvements of the NMSS domain sleep/fatigue and PDQ-8 total score (0.32, P = 0.0001) as well as between the NMSS domain mood/cognition and PDQ-8 total score (0.37, P < 0.0001) were also shown. Conclusions This analysis demonstrated positive associations between NMSS baseline burden and improvements of non-motor symptoms. Improvements of non-motor symptoms were associated with improved quality of life in advanced parkinsonian patients during a 2-year treatment with LCIG and reflect the long-term non-motor efficacy of this treatment.", "subjects" : [ { "otype" : "Classification", "mtid" : 12125, "link" : "/api/classification/12125", "label" : "Általános orvostudomány", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12215, "link" : "/api/classification/12215", "label" : "Klinikai orvostan", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 4156, "link" : "/api/keyword/4156", "label" : "Quality of Life", "published" : true, "oldId" : 4156, "snippet" : true }, { "otype" : "Keyword", "mtid" : 17403, "link" : "/api/keyword/17403", "label" : "Parkinson's disease", "published" : true, "oldId" : 17403, "snippet" : true }, { "otype" : "Keyword", "mtid" : 17849, "link" : "/api/keyword/17849", "label" : "non-motor symptoms", "published" : true, "oldId" : 17849, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1704938, "link" : "/api/keyword/1704938", "label" : "levodopa-carbidopa intestinal gel", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1704939, "link" : "/api/keyword/1704939", "label" : "routine patient care", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2019, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2023-05-05", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 2, "citedCount" : 2, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10861449, "link" : "/api/sjrrating/10861449", "label" : "sjr:Q1 (2019) Scopus - Neurology (clinical) EUROPEAN JOURNAL OF NEUROLOGY 1351-5101 1468-1331", "listPos" : 42, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2728, "link" : "/api/classificationexternal/2728", "label" : "Scopus - Neurology (clinical)", "published" : true, "oldId" : 2728, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : false, "userChangeableUntil" : "2019-06-16T17:34:35.696+0000", "publishDate" : "2019-03-18T18:34:35.758+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 21, "ownerInstituteCount" : 39, "directInstituteCount" : 0, "authorCount" : 6, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/30603494", "label" : "Chaudhuri K. 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