Thyroglobulin level at week 16 of pregnancy is superior to urinary iodine concentration in revealing preconceptual and first trimester iodine supply

Katkó, Mónika [Katkó, Mónika (Biológia), szerző]; Gazsó, Andrea; Hircsu, Ildikó; Bhattoa, Harjit Pal [Bhattoa Harjit, Pál (Orvosi laboratóri...), szerző]; Molnár, Zsuzsanna [Molnár, Zsuzsanna (orvosi laboratóri...), szerző]; Kovács, Béla [Kovács, Béla (Mezőgazdasági kémia), szerző] Élelmiszertudományi Intézet (DE / MÉK); Andrási, Dávid; Aranyosi, János; Makai, Rita; Veress, Lajos; Török, Olga [Török, Olga (szülészet-nőgyógy...), szerző]; Bodor, Miklós [Bodor, Miklós (Endokrinológia, K...), szerző]; Sámson, László; Nagy, Endre V. [Nagy, Endre (Endokrinológia), szerző]

Angol nyelvű Tudományos Szakcikk (Folyóiratcikk)
Megjelent: MATERNAL AND CHILD NUTRITION 1740-8695 14 (1) pp. 1-9 2018
  • SJR Scopus - Obstetrics and Gynecology: D1
Azonosítók
Pregnant women are prone to iodine deficiency due to the increased need for iodine during gestation.Progress has recently occurred in establishing serum thyroglobulin (Tg) as an iodine statusbiomarker, but there is no accepted reference range for iodine sufficiency during pregnancy. Anobservational study was conducted in 164 pregnant women. At week 16 of gestation urinaryiodine concentration (UIC), serum Tg, and thyroid functions were measured, and information onthe type of iodine supplementation and smoking were recorded. The parameters of those whostarted iodine supplementation (?150 ?g/day) at least 4 weeks before pregnancy (n = 27), whostarted at the detection of pregnancy (n = 51), and who had no iodine supplementation (n = 74)were compared. Sufficient iodine supply was found in the studied population based on medianUIC (162 ?g/L). Iodine supplementation ?150 ?g/day resulted in higher median UIC regardlessof its duration (nonusers: 130 ?g/L vs. prepregnancy iodine starters: 240 ?g/L, and pregnancyiodine starters: 205 ?g/L, p < .001, and p = .023, respectively). Median Tg value of pregnancystarters was identical to that of nonusers (14.5 vs. 14.6 ?g/L), whereas prepregnancy startershad lower medianTg (9.1 ?g/L, p = .018). SerumTg concentration at week 16 of pregnancy showednegative relationship (p = .010) with duration of iodine supplementation and positive relationship(p = .008) with smoking, a known interfering factor of iodine metabolism, by multiple regressionanalysis. Serum Tg at week 16 of pregnancy may be a promising biomarker of preconceptual andfirst trimester maternal iodine status, the critical early phase of foetal brain development.
Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
2020-09-23 17:16