{ "labelLang" : "hun", "responseDate" : "2024-03-29 11:29", "content" : { "otype" : "JournalArticle", "mtid" : 30598458, "status" : "VALIDATED", "published" : true, "comment" : "Funding Agency and Grant Number: Japan Society for the Promotion of Science (JSPS) (KAKENHI)Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [18K12071]; \"Compass to Healthy Life\" Research Complex Program of Japan Science and Technology Agency (JST)\n Funding text: We thank Professor Washizu of Tokyo University (Tokyo, Japan) and Professor Okeyo of Kyoto University (Kyoto, Japan) for valuable discussions and suggestions. This research was supported by grants from the Japan Society for the Promotion of Science USPS) (KAKENHI Grant Numbers: 18K12071), and the \"Compass to Healthy Life\" Research Complex Program of Japan Science and Technology Agency (JST).", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2022-10-11T13:32:23.941+0000", "lastModified" : "2019-03-13T18:11:24.099+0000", "created" : "2019-03-14T07:00:28.082+0000", "creator" : { "otype" : "Admin", "mtid" : 565, "link" : "/api/admin/565", "label" : "WoS import (admin)", "familyName" : "WoS", "givenName" : "import", "published" : true, "snippet" : true }, "lastDuplumSearch" : "2023-11-14T16:00:24.091+0000", "validated" : "2019-03-14T07:00:30.145+0000", "validator" : { "otype" : "Admin", "mtid" : 565, "link" : "/api/admin/565", "label" : "WoS import (admin)", "familyName" : "WoS", "givenName" : "import", "published" : true, "snippet" : true }, "core" : false, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Li, Zhuosi", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 86490703, "link" : "/api/authorship/86490703", "label" : "Li, Zhuosi", "listPosition" : 1, "share" : 0.0, "first" : true, "last" : false, "familyName" : "Li", "givenName" : "Zhuosi", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 86490704, "link" : "/api/authorship/86490704", "label" : "Kurosawa, Osamu", "listPosition" : 2, "share" : 0.0, "first" : false, "last" : false, "familyName" : "Kurosawa", "givenName" : "Osamu", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 86490705, "link" : "/api/authorship/86490705", "label" : "Iwata, Hiroo", "listPosition" : 3, "share" : 0.0, "first" : false, "last" : true, "familyName" : "Iwata", "givenName" : "Hiroo", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true } ], "title" : "Development of trophoblast cystic structures from human induced pluripotent stem cells in limited-area cell culture", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 15500222, "link" : "/api/publicationidentifier/15500222", "label" : "DOI: 10.1016/j.bbrc.2018.09.181", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "10.1016/j.bbrc.2018.09.181", "realUrl" : "https://doi.org/10.1016%2Fj.bbrc.2018.09.181", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 15500221, "link" : "/api/publicationidentifier/15500221", "label" : "WoS: 000449244000006", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "https://www.webofscience.com/wos/woscc/full-record/WOS:@@@", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "000449244000006", "realUrl" : "https://www.webofscience.com/wos/woscc/full-record/WOS:000449244000006", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 21789148, "link" : "/api/publicationidentifier/21789148", "label" : "Scopus: 85054173849", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "85054173849", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85054173849", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 18456689, "link" : "/api/publicationidentifier/18456689", "label" : "PubMed: 30292409", "source" : { "otype" : "PlainSource", "mtid" : 17, "link" : "/api/publicationsource/17", "label" : "PubMed", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "PubMed", "nameEng" : "PubMed", "linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "30292409", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30292409&dopt=Abstract", "published" : false, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 679, "link" : "/api/journal/679", "label" : "BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 0006-291X 1090-2104", "pIssn" : "0006-291X", "eIssn" : "1090-2104", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 679, "snippet" : true }, "volume" : "505", "issue" : "3", "firstPage" : "671", "lastPage" : "676", "firstPageOrInternalIdForSort" : "671", "pageLength" : 6, "publishedYear" : 2018, "abstractText" : "We developed a novel engineering technique to induce differentiation of human induced pluripotent stem cells (hiPSCs) into organoids mimicking the trophectoderm (TE). Here, hiPSCs were cultured on a limited area of 2-4 mm in diameter. After 15-20 days, spherical cysts appeared on the surface of the limited area. Secretion of human chorionic gonadotrophin (hCG) began to increase after -20 days and remained dramatically elevated over the next 20 days. Limited-area-cultured cysts exhibited expression of hCG, which was a result of epithelial differentiation. Low expression levels of pluripotent genes and high expression levels of trophoblast lineage-specific genes were detected in the cells of spherical cysts. Multinucleated syncytia trophoblast was observed in the reseeded cystic cells. We observed hiPSC-derived cysts that morphologically resembled trophectoderm in vivo. The limited-area cell culture induced a three-dimensional (3D) trophectoderm organoid, which has potential for use in the study of human trophoblast differentiation and placental morphogenesis. (C) 2018 Elsevier Inc. All rights reserved.", "subjects" : [ { "otype" : "Classification", "mtid" : 10545, "link" : "/api/classification/10545", "label" : "Biológiai tudományok", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 1011007, "link" : "/api/keyword/1011007", "label" : "cyst", "published" : true, "oldId" : 1011007, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1014776, "link" : "/api/keyword/1014776", "label" : "trophoblast", "published" : true, "oldId" : 1014776, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1085569, "link" : "/api/keyword/1085569", "label" : "hCG", "published" : true, "oldId" : 1085569, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1512703, "link" : "/api/keyword/1512703", "label" : "trophectoderm", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1534225, "link" : "/api/keyword/1534225", "label" : "hiPSC", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2019, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2022-10-11", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 2, "citedCount" : 2, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10750898, "link" : "/api/sjrrating/10750898", "label" : "sjr:Q2 (2018) Scopus - Biochemistry BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 0006-291X 1090-2104", "listPos" : 166, "rankValue" : 0.49, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 1303, "link" : "/api/classificationexternal/1303", "label" : "Scopus - Biochemistry", "published" : true, "oldId" : 1303, "snippet" : true }, "ranking" : "Q2", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q2", "hasCitationDuplums" : false, "directInstitutesForSort" : "", "ownerAuthorCount" : 9, "ownerInstituteCount" : 79, "directInstituteCount" : 0, "authorCount" : 3, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/30598458", "label" : "Li Zhuosi et al. Development of trophoblast cystic structures from human induced pluripotent stem cells in limited-area cell culture. (2018) BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 0006-291X 1090-2104 505 3 671-676", "template" : "