https://m2.mtmt.hu/ hun 2026-10-25 12:42 JournalArticle 30590806 VALIDATED true 0 false 2026-10-19T14:24:02.618+0000 2024-11-12T10:18:02.822+0000 2019-03-12T22:54:03.994+0000 true 565 WoS import /api/admin/565 Admin true 2024-11-12T15:33:52.045+0000 2024-11-12T15:33:52.045+0000 2024-11-12T10:18:02.997+0000 true 10023792 Suchanek-Lukács Margit /api/admin/10023792 Admin true 10023792 Admin 10023792 /api/admin/10023792 Suchanek-Lukács Margit true 10023792 true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2024-10-17T16:35:19.342+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Keeley, A. Design and characterization of a heterocyclic electrophilic fragment library for the discovery of cysteine-targeted covalent inhibitors Med. Chem. Commun., 2019, Advance Article true true /api/journal/10015838 REVIEWED true false 10015838 false 10015838 true 2040-2503 2040-2511 Journal FOREIGN 10 2 263 267 263 5 2019 A fragment library of electrophilic small heterocycles was characterized through cysteine-reactivity and aqueous stability tests that suggested their potential as covalent warheads. The analysis of theoretical and experimental descriptors revealed correlations between the electronic properties of the heterocyclic cores and their reactivity against GSH that are helpful in identifying suitable fragments for cysteines with specific nucleophilicity. The most important advantage of these fragments is that they show only minimal structural differences from non-electrophilic counterparts. 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M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 15485925 /api/publicationidentifier/15485925 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1039/c8md00327k https://doi.org/10.1039/c8md00327k false true PublicationIdentifier 15485924 /api/publicationidentifier/15485924 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000459510800007 https://www.webofscience.com/wos/woscc/full-record/000459510800007 false true PublicationIdentifier 18496781 /api/publicationidentifier/18496781 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85062232704 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85062232704 false true PublicationIdentifier 15125812 /api/publicationidentifier/15125812 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true http://pubs.rsc.org/en/Content/ArticleLanding/2018/MD/C8MD00327K http://pubs.rsc.org/en/Content/ArticleLanding/2018/MD/C8MD00327K false true Classification 12125 /api/classification/12125 true true Classification 10545 /api/classification/10545 true true Classification 10398 /api/classification/10398 true true Classification 10293 /api/classification/10293 true true SjrRating 10872192 /api/sjrrating/10872192 48 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3003 /api/classificationexternal/3003 true 3003 true Q1 DIRECT true true /api/publication/30590806 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10061376"><a href="/gui2/?type=authors&mode=browse&sel=10061376" target="_blank">Keeley A. (<span class="authorship-author-name">Keeley Aaron Brian</span> <span class="authorAux-mtmt"> kémiai tudományok</span>) </a> </span> <span class="author-affil"><span title="MTA Természettudományi Kutatóközpont">MTA TTK</span>/<span title="Szerves Kémiai Intézet">SZKI</span>/Gyógyszerkémiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042926"><a href="/gui2/?type=authors&mode=browse&sel=10042926" target="_blank">Abranyi-Balogh P. (<span class="authorship-author-name">Ábrányi-Balogh Péter</span> <span class="authorAux-mtmt"> szerves kémia</span>) </a> </span> <span class="author-affil"><span title="MTA Természettudományi Kutatóközpont">MTA TTK</span>/<span title="Szerves Kémiai Intézet">SZKI</span>/Gyógyszerkémiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001451"><a href="/gui2/?type=authors&mode=browse&sel=10001451" target="_blank">Keseru G. M. ✉ (<span class="authorship-author-name">Keserű György Miklós</span> <span class="authorAux-mtmt"> Gyógyszerkémia, gyógyszertervezés</span>) </a> </span> <span class="author-affil"><span title="MTA Természettudományi Kutatóközpont">MTA TTK</span>/<span title="Szerves Kémiai Intézet">SZKI</span>/Gyógyszerkémiai Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30590806" target="_blank">Design and characterization of a heterocyclic electrophilic fragment library for the discovery of cysteine-targeted covalent inhibitors</a></div> <div> <span class="journal-title">MEDCHEMCOMM</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2040-2503">2040-2503</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2040-2511">2040-2511</a>)</span>: <span class="journal-volume">10</span> <span class="journal-issue">2</span> <span class="page"> pp 263-267 </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1039/c8md00327k" target="_blank" href="https://doi.org/10.1039/c8md00327k"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000459510800007" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000459510800007"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85062232704" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85062232704"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="http://pubs.rsc.org/en/Content/ArticleLanding/2018/MD/C8MD00327K" target="_blank" href="http://pubs.rsc.org/en/Content/ArticleLanding/2018/MD/C8MD00327K"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Drug Discovery&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 72</span> | Független: 62 | Függő: 10 | Nem jelölt: 0 | WoS jelölt: 72 | Scopus jelölt:&nbsp;45 | WoS/Scopus jelölt:&nbsp;72 | DOI jelölt:&nbsp;72 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30590806&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 30590806</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WoS XML</span> </div> <div class="lastModified">Utolsó módosítás: 2024.11.12. 11:18 Suchanek-Lukács Margit (Admin 3, admin) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:35 Suchanek-Lukács Margit (Admin 3, admin) Ladányi Gusztáv (MTMT API user, admin) </div> </div></div>