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Laboratory of Immunology, Institute of Genetics, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, 6726, Hungary
Laboratory of Drosophila Germ Cell Differentiation, Institute of Genetics, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, 6726, Hungary
Department of Genetics, Faculty of Science and Informatics, University of Szeged, Szeged, 6726, Hungary
Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany
Cited By :3
Export Date: 19 January 2022
Correspondence Address: Andó, I.; Laboratory of Immunology, Hungary; email: ando.istvan@brc.mta.hu
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Varga, Gergely I B
Headcase is a Repressor of Lamellocyte Fate in Drosophila melanogaster
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Due to the evolutionary conservation of the regulation of hematopoiesis, Drosophila provides an excellent model organism to study blood cell differentiation and hematopoietic stem cell (HSC) maintenance. The larvae of Drosophila melanogaster respond to immune induction with the production of special effector blood cells, the lamellocytes, which encapsulate and subsequently kill the invader. Lamellocytes differentiate as a result of a concerted action of all three hematopoietic compartments of the larva: the lymph gland, the circulating hemocytes, and the sessile tissue. Within the lymph gland, the communication of the functional zones, the maintenance of HSC fate, and the differentiation of effector blood cells are regulated by a complex network of signaling pathways. Applying gene conversion, mutational analysis, and a candidate based genetic interaction screen, we investigated the role of Headcase (Hdc), the homolog of the tumor suppressor HECA in the hematopoiesis of Drosophila. We found that naive loss-of-function hdc mutant larvae produce lamellocytes, showing that Hdc has a repressive role in effector blood cell differentiation. We demonstrate that hdc genetically interacts with the Hedgehog and the Decapentaplegic pathways in the hematopoietic niche of the lymph gland. By adding further details to the model of blood cell fate regulation in the lymph gland of the larva, our findings contribute to the better understanding of HSC maintenance.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10043444"> <a href="/gui2/?type=authors&mode=browse&sel=10043444" target="_blank">Varga, Gergely I B</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10024943"> <a href="/gui2/?type=authors&mode=browse&sel=10024943" target="_blank">Csordás, Gábor</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10013034"> <a href="/gui2/?type=authors&mode=browse&sel=10013034" target="_blank">Cinege, Gyöngyi</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10011010"> <a href="/gui2/?type=authors&mode=browse&sel=10011010" target="_blank">Jankovics, Ferenc</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10011011"> <a href="/gui2/?type=authors&mode=browse&sel=10011011" target="_blank">Sinka, Rita</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10009522"> <a href="/gui2/?type=authors&mode=browse&sel=10009522" target="_blank">Kurucz, Éva</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10004457"> <a href="/gui2/?type=authors&mode=browse&sel=10004457" target="_blank">Andó, István ✉</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10020760"> <a href="/gui2/?type=authors&mode=browse&sel=10020760" target="_blank">Honti, Viktor ✉</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;30585796" mtid="30585796" target="_blank">Headcase is a Repressor of Lamellocyte Fate in Drosophila melanogaster</a></div> <div class="pub-info"> <span class="journal-title">GENES</span> <span class="journal-volume">10</span> : <span class="journal-issue">3</span> <span class="page"> Paper: 173 , 17 p. </span> <span class="year">(2019)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/genes10030173" target="_blank" href="https://doi.org/10.3390/genes10030173"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000464471700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000464471700001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="103690" target="_blank" href="http://real.mtak.hu/103690"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85064606949" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85064606949"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="30841641" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30841641&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="20090" target="_blank" href="http://publicatio.bibl.u-szeged.hu/20090"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="deleted-record">Locked</span> <span class="short-pub-mtid"> Publication:30585796 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Validated </span></span> <span class="pub-core">Core Citing </span> <span class="pub-type">Journal Article (Article ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Scientific</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 4</span> | Independent citation: 3 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 4 | Number of citations in Scopus: 4 | WoS/Scopus assigned: 4 | Number of citations with DOI: 4 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<span class="author-affil"><span title="Biological Research Centre, Szeged">BRC Szeged</span>/Institute of Genetics</span>
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<span class="author-affil"><span title="Biological Research Centre, Szeged">BRC Szeged</span>/Institute of Genetics</span>
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<span class="author-affil"><span title="Biological Research Centre, Szeged">BRC Szeged</span>/Institute of Genetics</span>
;
<span class="author-name" mtid="10020760"><a
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<span class="author-affil"><span title="Biological Research Centre, Szeged">BRC Szeged</span>/Institute of Genetics</span>
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;30585796" target="_blank">Headcase is a Repressor of Lamellocyte Fate in Drosophila melanogaster</a></div> <div> <span class="journal-title">GENES</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2073-4425">2073-4425</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2073-4425">2073-4425</a>)</span>:
<span class="journal-volume">10</span> <span class="journal-issue">3</span>
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Paper 173.
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<span title="" class="citingPub-count">Citing papers: 4</span>
| Independent citation: 3
| Self citation: 1
| Unknown citation: 0
| Number of citations in WoS: 4
| Number of citations in Scopus: 4
| WoS/Scopus assigned: 4
| Number of citations with DOI: 4
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<div class="lastModified">Last Modified: 2020.12.15. 10:43 Petra Csonka (SZTE admin5 SZAOK Anatómia)
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<div class="lockedBy">Temporarily locked 2024.03.25. 16:35 Andrea Vándor (VA, admin)
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Laboratory of Immunology, Institute of Genetics, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, 6726, Hungary
Laboratory of Drosophila Germ Cell Differentiation, Institute of Genetics, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, 6726, Hungary
Department of Genetics, Faculty of Science and Info...</pre>
</div></div>