The aim of this study was synthesizing two steroid derivatives to evaluate their theoretical
interact with a 17 beta-hydroxysteroid dehydrogenase type 1. The first stage was achieved
by the preparation of a steroid-imino analog (compound 2) using a reaction of imination
and ii) etherification. Then, the theoretical interact of two steroid analogs with
17 beta-hydroxysteroid dehydrogenase type 1 (IIOL) was evaluated using fisetin and
methyl paraben as controls in a docking model. The results suggest that steroid derivatives
could interact via a different type of aminoacid residues of IIOL protein surface.
However, the compound 2 showed a constant of inhibition lower compared with fisetin,
methyl paraben and compound 3. All these data indicate that steroid derivative could
act as 17 beta-hydroxysteroid dehydrogenase type 1 inhibitor.