Preparation of two steroid derivatives and its theoretical interaction with a 17 beta-hydroxysteroid dehydrogenase type 1

Lauro, Figueroa-Valverde; Abelardo, Camacho-Luis; Francisco, Diaz-Cedillo; Marcela, Rosas-Nexticapa; Virginia, Mateu-Armand; Patricia, Hernandez-Vasquez; Eduardo, Pool-Gomez; Maria, Lopez-Ramos; Lenin, Hau-Heredia; Tomas Joel, Lopez-Gutierrez; Bety, Sarabia-Alcocer; Alondra, Alfonso-Jimenez; Jhair, Cabrera-Tuz

Angol nyelvű Tudományos Szakcikk (Folyóiratcikk)
Megjelent: BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY 2069-5837 9 (1) pp. 3800-3805 2019
  • SJR Scopus - Biochemistry: Q4
    The aim of this study was synthesizing two steroid derivatives to evaluate their theoretical interact with a 17 beta-hydroxysteroid dehydrogenase type 1. The first stage was achieved by the preparation of a steroid-imino analog (compound 2) using a reaction of imination and ii) etherification. Then, the theoretical interact of two steroid analogs with 17 beta-hydroxysteroid dehydrogenase type 1 (IIOL) was evaluated using fisetin and methyl paraben as controls in a docking model. The results suggest that steroid derivatives could interact via a different type of aminoacid residues of IIOL protein surface. However, the compound 2 showed a constant of inhibition lower compared with fisetin, methyl paraben and compound 3. All these data indicate that steroid derivative could act as 17 beta-hydroxysteroid dehydrogenase type 1 inhibitor.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2021-05-13 04:57