https://m2.mtmt.hu/ hun 2026-08-25 11:44 JournalArticle 30547689 APPROVED true Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Department of Psychiatry, Massachusetts General Hospital, Boston, United States Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, United States Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, United States Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, United States Department of Molecular Biology and Genetics, Democritus University of Thrace, Xanthi, Greece Department of Biological Sciences, Purdue University, West Lafayette, ID, United States DeCODE Genetics/Amgen, Reykjavik, Iceland Bioinformatics Interdepartmental Program, University of California, Los Angeles, United States Department of Psychiatry, University of California, San Francisco, United States Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, United States Department of Psychiatry, Massachusetts General Hospital, Boston, United States Clinic of Psychiatry, Social Psychiatry, and Psychotherapy, Hannover Medical School, Hannover, Germany Institute of Human Genetics, Hannover Medical School, Hannover, Germany McGill University Health Center, University of Montreal, McGill University Health Centre, Montreal, Canada Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Canada Department of Psychiatry and Psychotherapy, Medical University Vienna, Vienna, Austria Biopsychosocial Corporation, Vienna, Austria University Health Network, Youthdale Treatment Centres, University of Toronto, Toronto, Canada Krembil Research Institute, University Health Network, Hospital for Sick Children, University of Toronto, Toronto, Canada Johns Hopkins University, School of Medicine, Baltimore, United States Institute of Human Genetics, University Hospital Bonn, University of Bonn Medical School, Bonn, Germany Department of Child and Adolescent Psychiatry, Psycho-somatics, and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany Yale Child Study Center, Department of Psychiatry, Yale University, School of Medicine, New Haven, MA, United States Institute of Medical Chemistry, Molecular Biology, and Pathobiochemistry, Semmelweis University, Budapest, Hungary Vadaskert Child and Adolescent Psychiatric Hospital, Budapest, Hungary Institute of Human Genetics, University Hospital Essen, University Duisburg-Essen, Essen, Germany Sorbonne Universités, UPMC Université Paris 06, UMR S 1127, CNRS UMR 7225, ICM, Paris, France French Reference Centre for Gilles de la Tourette Syndrome, Groupe Hospitalier Pitié-Salpêtrière, Paris, France Assistance Publique-Hôpitaux de Paris, Department of Neurology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United States Child Neuropsychiatry, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, United States Department of Psychiatry, University of Utah, Salt Lake City, United States Children's Mercy Hospital, Kansas City, MO, United States Department of Psychiatry, University Medical Center Groningen, Rijks-university Groningen, Drenthe Mental Health Center, Groningen, Netherlands Department of Neurology, Fixel Center for Neurological Diseases, McKnight Brain Institute, University of Florida, Gainesville, United States Pennsylvania State University, College of Medicine, Hershey, United States Marquette University, University of Wisconsin-Milwaukee, Milwaukee, United States Tripler Army Medical Center, University of Hawaii John A. Burns, School of Medicine, Honolulu, United States Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, United States Division of Psychiatry, Department of Neuropsychiatry, University College London, United Kingdom Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, United States Children's Hospital of Philadelphia, Philadelphia, United States Department of Psychiatry and Behavioral Sciences, University of Miami Miller, School of Medicine, Miami, United States Department of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, Netherlands University of Iowa Carver, College of Medicine, Iowa City, United States Department of Pediatrics, University of Washington, Seattle, United States Department of Pediatrics, Landspitalinn University Hospital, Reykjavik, Iceland Faculty of Medicine, University of Iceland, Reykjavík, Iceland State Diagnostic and Coun-selling Centre, Kópavogur, Iceland Department of Genetics, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, United States Department of Human Biology, Haifa University, Haifa, Israel Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany SUNY Downstate Medical Center, Brooklyn, NY, United States Athinoula A. Martinos Center for Biomedical Research, Department of Radiology, Massachusetts General Hospital, Charlestown, United States Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, United States Center for Brain Science, Department of Psychology, Harvard University, Cambridge, MA, United States Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, United States Department of Genetics, Human Genetics Institute of New Jersey, Rutgers, State University of New Jersey, Piscataway, United States Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, Amsterdam, Netherlands Division of Genetic Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, United States Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, United States Department of Psychiatry, Genetics Institute, University of Florida, Gainesville, United States Department of Neurology, Brigham and Women's Hospital, Department of Neurology, Massachusetts General Hospital, Boston, United States Cited By :108 Export Date: 1 March 2023 CODEN: AJPSA Correspondence Address: Scharf, J.M.; Psychiatric and Neurodevelopmental Genetics Unit, United States; email: jscharf@partners.org Chemicals/CAS: FLT3 protein, human; fms-Like Tyrosine Kinase 3 Funding details: MH096767, NS040024-07S1, NS040024-09S1 Funding details: U01 HG004422 Funding details: P30AG038072, R01AG042188 Funding details: National Science Foundation, NSF, 1715202 Funding details: National Institutes of Health, NIH, P01AG021654, R01MH092289, R01MH092290, R01MH092291, R01MH092292, R01MH092293, R01MH092513, R01MH092516, R01MH092520 Funding details: National Institute of Mental Health, NIMH, K23MH085057, R01MH096767, R01MH115958, R25MH077823, U01MH109536 Funding details: National Institute on Drug Abuse, NIDA, HHSN268200782096C Funding details: National Institute on Alcohol Abuse and Alcoholism, NIAAA Funding details: National Institute of Neurological Disorders and Stroke, NINDS, K02NS085048, P30NS062691, R01NS016648, U01NS040024 Funding details: Center for Information Technology, CIT Funding details: Women's Health Initiative, WHI Funding details: Greater Boston Council on Alcoholism, GBCoA, U10 AA008401 Funding details: Johns Hopkins University, JHU, U01HG004438 Funding details: Tourette Association of America, TAA Funding details: Collaborative Spine Research Foundation, CSRF, P01 CA089392 Funding details: Seattle Genetics Funding details: Australian Institute of Family Studies, AIFS, R01 DA013423 Funding details: Research Trainees Coordinating Centre, TCC, U01 HG004446 Funding details: Directorate-General for the Environment Funding details: Deutsche Forschungsgemeinschaft, DFG Funding details: National Radio Research Agency, RRA Funding details: Centre of Excellence in Plant Energy Biology, Australian Research Council, PEB Funding details: Retinologische Gesellschaft Funding details: Faculty of Science, Agriculture and Engineering, Newcastle University, SAgE Funding text 1: Prothena Biosciences, Parexel, Revance Therapeutics, Retrophin, and Teva; he has received royalties from Cambridge, Elsevier, Future Science Group,HodderArnold,Medlink:Neurology,LippincottWilliams&Wilkins, and Wiley-Blackwell; and he serves on the editorial boards of Expert Review of Neurotherapeutics, Medlink, Neurology in Clinical Practice, the Botulinum Journal, PeerJ, Therapeutic Advances in Neurological Disorders, Neurotherapeutics, Tremor and Other Hyperkinetic Movements, and the Journal of Parkinson’s Disease. Dr. Coffey is on the scientific advisory boards of Abide Therapeutics and Genco Sciences; she receives honoraria from the American Academy of Child and Adolescent Psychiatry; she receives research support from Catalyst Pharmaceuticals, Neurocrine Biosciences, NIMH/UCSF, Otsuka, and Shire; she is on the scientific advisory boards of and receives research support from Auspex, Teva, and Nuvelution; and she is a co-chair and on the medical advisory board of the TAA, TAA-CDC Partnership. Dr. Kuperman is involved with Neurocrine for the purpose of recruiting a small number of individuals with Tourette syndrome for enrollment in a drug trial for a new medication to treat severe Tourette’s syndrome. Dr. Wagner has received a nonprofit grant from the German Research Foundation. Dr. Smoller is an unpaid member of the Bipolar/Depression Research Community Advisory Panel of 23andMe. Dr. Buckner has served as a consultant for Roche. Dr. Willsey has served as a consultant for Daiichi Sankyo. Dr. Heiman has received funding from the New Jersey Center for Tourette Syndrome and Associated Disorders. Dr.NealeisamemberofthescientificadvisoryboardforDeepGenomics and serves as a consultant for Avanir, Camp4 Therapeutics, and Merck. Dr. Mathews has received research support, honoraria, and travel support from the TAA and is a co-chair of the TAA scientific advisory board. Dr. Scharf has received consulting fees from Nuvelution Pharma and Abide Pharmaceuticals; he has received travel and grant support from the TAA and the TLC Foundation for Body-Focused Repetitive Behaviors; and he is a member of the scientific advisory boards for the TAA and the TLC Foundation for Body-Focused Repetitive Behaviors. The other authors report no financial relationships with commercial interests. Funding text 2: Supported by NIH grants U01 NS040024 to Drs. Pauls, Mathews, and Scharf and the Tourette Association of America International Consortium for Genetics, NIH grants K23 MH085057 and K02 NS085048 and ARRA grant NS040024-09S1 to Dr. Scharf, NIH grant NS016648 and ARRA grant NS040024-07S1 to Dr. Pauls, grant MH096767 to Dr. Mathews, National Institute of Neurological Disorders and Stroke (NINDS) Informatics Center for Neurogenetics and Neurogenomics grant P30 NS062691 to Drs. Coppola and Freimer, and grants from the Tourette Association of America to Drs. Paschou, Pauls, Mathews, and Scharf. This study was also funded in part by NIH grants R01MH092290 to Dr. Brown, R01MH092291 to Dr. Kuperman, R01MH092292 to Dr. Coffey, R01MH092293 to Dr. Heiman, R01MH092513 to Dr. Zinner, R01MH092516 to Dr. Grice, R01MH092520 to Dr. Gilbert, R01MH092289 to Dr. State, P01AG021654 and the Nathan Shock Center of Excellence for the Biology of Aging P30AG038072 to Dr. Barzilai, and R01AG042188 to Dr. Atzmon, as well as a grant from the German Research Society to Dr. Hebebrand. Funding support for the Study of Addiction: Genetics and Environment (SAGE) was provided through the NIH Genes, Environment, and Health Initiative [GEI] (U01 HG004422); SAGE is one of the genomewide association studies funded as part of the Gene Environment Association Studies (GENEVA) under the NIH GEI. Assistance with phenotype harmonization and genotype cleaning, as well as with general study coordination, was provided by the GENEVA Coordinating Center (U01 HG004446). Assistance with data cleaning was provided by the National Center for Biotechnology Information. Support for collection of data sets and samples was provided by the Collaborative Study on the Genetics of Alcoholism (U10 AA008401), the Collaborative Genetic Study of Nicotine Dependence (P01 CA089392), and the Family Study of Cocaine Dependence (R01 DA013423). Funding support for genotyping, which was performed at the Johns Hopkins University Center for Inherited Disease Research, was provided by the NIH GEI (U01HG004438), the National Institute on Alcohol Abuse and Alcoholism, NIDA, and the NIH contract “High Throughput Genotyping for Studying the Genetic Contributions to Human Disease” (HHSN268200782096C). The data sets used for the analyses described here were obtained from dbGaP (http://www.ncbi.nlm. nih.gov/projects/gap/cgibin/study.cgi?study_id=phs000092.v1.p1) through dbGaP accession number phs000092.v1.p. Funding text 3: Supported by NIH grants U01 NS040024 to Drs. Pauls, Mathews, and Scharf and the Tourette Association of America International Consortium for Genetics, NIH grants K23 MH085057 and K02 NS085048 and ARRA grant NS040024-09S1 to Dr. Scharf, NIH grant NS016648 and ARRA grant NS040024-07S1 to Dr. Pauls, grant MH096767 to Dr. Mathews, National Institute of Neurological Disorders and Stroke (NINDS) Informatics Center for Neurogenetics and Neurogenomics grant P30 NS062691 to Drs. Coppola and Freimer, and grants from the Tourette Association of America to Drs. Paschou, Pauls, Mathews, and Scharf. This study was also funded in part by NIH grants R01MH092290 to Dr. Brown, R01MH092291 to Dr. Kuperman, R01MH092292 to Dr. Coffey, R01MH092293 to Dr. Heiman, R01MH092513 to Dr. Zinner, R01MH092516 to Dr. Grice, R01MH092520 to Dr. Gilbert, R01MH092289 to Dr. State, P01AG021654 and the Nathan Shock Center of Excellence for the Biology of Aging P30AG038072 to Dr. Barzilai, and R01AG042188 to Dr. Atzmon, as well as a grant from the German Research Society to Dr. Hebebrand. Funding support for the Study of Addiction: Genetics and Environment (SAGE) was provided through the NIH Genes, Environment, and Health Initiative [GEI] (U01 HG004422); SAGE is one of the genome-wide association studies funded as part of the Gene Environment Association Studies (GENEVA) under the NIH GEI. Assistance with phenotype harmonization and genotype cleaning, as well as with general study coordination, was provided by the GENEVA Coordinating Center (U01 HG004446). Assistance with data cleaning was provided by the National Center for Biotechnology Information. Support for collection of data sets and samples was provided by the Collaborative Study on the Genetics of Alcoholism (U10 AA008401), the Collaborative Genetic Study of Nicotine Dependence (P01 CA089392), and the Family Study of Cocaine Dependence (R01 DA013423). Funding support for genotyping, which was performed at the Johns Hopkins University Center for Inherited Disease Research, was provided by the NIH GEI (U01HG004438), the National Institute on Alcohol Abuse and Alcoholism, NIDA, and the NIH contract “High Throughput Genotyping for Studying the Genetic Contributions to Human Disease” (HHSN268200782096C). 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(82) </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">Tourette Association of America International Consortium for Genetics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-affil">Gilles de la Tourette GWAS Replication Initiative</span> ;&nbsp;&nbsp;&nbsp; <span class="author-affil">Tourette International Collaborative Genetics Study</span> ;&nbsp;&nbsp;&nbsp; <span class="author-affil">Psychiatric Genomics Consortium Tourette Syndrome Working Group</span> </div> <div><a target="_blank" href="/api/publication/30547689?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30547689" target="_blank">Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies</a></div> <div> <span class="journal-title">AMERICAN JOURNAL OF PSYCHIATRY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0002-953X">0002-953X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1535-7228">1535-7228</a>)</span>: <span class="journal-volume">176</span> <span class="journal-issue">3</span> <span class="page"> pp 217-227 </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1176/appi.ajp.2018.18070857" target="_blank" href="https://doi.org/10.1176/appi.ajp.2018.18070857"> DOI </a> </span> <span class="id identifier oa_RESTRICTED" title=" Korlátozott "> <a style="color:blue" title="7390" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/7390"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000462846900007" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000462846900007"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85063063105" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85063063105"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="30818990" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30818990&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Psychiatry and Mental Health&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 298</span> | Független: 237 | Függő: 61 | Nem jelölt: 0 | WoS jelölt: 274 | Scopus jelölt:&nbsp;294 | WoS/Scopus jelölt:&nbsp;298 | DOI jelölt:&nbsp;296 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30547689&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 30547689</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.01.15. 12:02 Cserteg Dóra (Bethesda 4 admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Department of Psychiatry, Massachusetts General Hospital, Boston, United States Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, United States Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine...</pre> </div></div>