Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection

https://m2.mtmt.hu/ eng 2026-10-25 09:50 JournalArticle 3054080 VALIDATED true 0 2018-09-25T07:34:42.000+0000 false 3054080 2026-10-17T16:36:14.088+0000 2026-02-11T14:14:03.770+0000 2016-04-19T17:01:24.000+0000 true 10008942 Sperlágh Beáta /api/author/10008942 Author Beáta Sperlágh (Neurofarmakológia) true 10008942 2026-02-11T14:14:04.550+0000 2026-02-11T14:14:04.550+0000 2018-09-25T07:34:29.000+0000 true 10045364 Fi Tamás /api/admin/10045364 Admin Tamás Fi (SE_KK_Admin5_FT, admin) true 10045364 2022-03-21T09:55:39.028+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin Rita Tichy (SE_KK_Admin5_TR, admin) true 10026589 Admin 10063514 /api/admin/10063514 Katalin Mikola (MTMT 3, admin) Mikola Katalin true 10063514 true 2026-01-21T13:12:53.998+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Sodar, BW Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection true true /api/journal/10019966 REVIEWED SCIENTIFIC REPORTS 2045-2322 true false 10019966 false 10019966 true 2045-2322 Journal FOREIGN 6 24316 24316 12 2016 Circulating extracellular vesicles have emerged as potential new biomarkers in a wide variety of diseases. Despite the increasing interest, their isolation and purification from body fluids remains challenging. Here we studied human pre-prandial and 4 hours postprandial platelet-free blood plasma samples as well as human platelet concentrates. Using flow cytometry, we found that the majority of circulating particles within the size range of extracellular vesicles lacked common vesicular markers. We identified most of these particles as lipoproteins (predominantly low-density lipoprotein, LDL) which mimicked the characteristics of extracellular vesicles and also co-purified with them. Based on biophysical properties of LDL this finding was highly unexpected. Current state-of-the-art extracellular vesicle isolation and purification methods did not result in lipoprotein-free vesicle preparations from blood plasma or from platelet concentrates. Furthermore, transmission electron microscopy showed an association of LDL with isolated vesicles upon in vitro mixing. This is the first study to show co-purification and in vitro association of LDL with extracellular vesicles and its interference with vesicle analysis. Our data point to the importance of careful study design and data interpretation in studies using blood-derived extracellular vesicles with special focus on potentially co-purified LDL. true 2016 425780 true true true false true false GOLD 2026-10-17 true https://doi.org/10.1038/srep24316 true 10045364 Fi Tamás /api/admin/10045364 Admin Tamás Fi (SE_KK_Admin5_FT, admin) true 10045364 515 0 509 479 36 507 501 487 495 504 504 474 474 485 30 0 515 485 509 479 0 13 13 Folyóiratcikk Journal Article 24 499 Könyvrészlet Chapter in Book 25 10 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 6 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2016 0 9 8 9 8 2017 0 32 26 32 26 2018 0 35 28 35 28 2019 0 55 53 55 53 2020 0 56 55 56 55 2021 0 67 64 67 64 2022 0 58 58 58 58 2023 0 46 44 46 44 2024 0 64 59 64 59 2025 0 44 42 44 42 2026 0 48 47 48 47 D1 A nemzetközi false 10009113,10015596,10027645,10002323,10040711 false false false 2018-09-25T07:34:29.000+0000 2016-04-19T17:29:23.000+0000 Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); Molekuláris Farmakológia Kutatócsoport (KOKI / GYO); Szerves Kémiai Intézet (MTA TTK) 18 62 4 18 0 true 10063514 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 7851551 /api/authorship/7851551 Sodar, BW [Sódar, Barbara (immunológia), author] Department of Genetics, Cell- and Immunology (SU / FM / I) 1 0.055555556 true false Author 10043376 /api/author/10043376 Barbara Sódar (immunológia) Sódar Barbara true 10043376 true Sodar BW true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 24129104 true PersonAuthorship 7851552 /api/authorship/7851552 Kittel, A [Kittel, Ágnes (Sejtbiológia), author] Laboratory of Molecular Pharmacology (IEM / DP) 2 0.055555556 false false Author 10009113 /api/author/10009113 Ágnes Kittel (Sejtbiológia) Kittel Ágnes true 10009113 true Kittel A true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 24129103 true PersonAuthorship 7851553 /api/authorship/7851553 Paloczi, K [Pálóczi, Krisztina (immunológia, gene...), author] Department of Genetics, Cell- and Immunology (SU / FM / I) 3 0.055555556 false false Author 10024466 /api/author/10024466 Krisztina Pálóczi (immunológia, genetika) Pálóczi Krisztina true 10024466 true Paloczi K true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 24129102 true PersonAuthorship 7851554 /api/authorship/7851554 Vukman, KV [Visnovitzné Dr Vukman, Krisztina (biológia), author] Department of Genetics, Cell- and Immunology (SU / FM / I) 4 0.055555556 false false Author 10040711 /api/author/10040711 Krisztina Visnovitzné Dr Vukman (biológia) Visnovitzné Dr Vukman Krisztina true 10040711 true Vukman KV true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 24129101 true PersonAuthorship 7851555 /api/authorship/7851555 Osteikoetxea, X [Osteikoetxea, Xabier (immunológia, gene...), author] Department of Genetics, Cell- and Immunology (SU / FM / I) 5 0.055555556 false false Author 10052584 /api/author/10052584 Xabier Osteikoetxea (immunológia, genetika) Osteikoetxea Xabier true 10052584 true Osteikoetxea X true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 24129100 true PersonAuthorship 7851556 /api/authorship/7851556 Szabo-Taylor, K [Szabó-Taylor, Katalin (Immunológia), author] Department of Genetics, Cell- and Immunology (SU / FM / I) 6 0.055555556 false false Author 10027645 /api/author/10027645 Katalin Szabó-Taylor (Immunológia) Szabó-Taylor Katalin true 10027645 true Szabo-Taylor K true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 24129099 true PersonAuthorship 7851557 /api/authorship/7851557 Nemeth, A [Németh, Andrea (immunológia), author] Department of Genetics, Cell- and Immunology (SU / FM / I) 7 0.055555556 false false Author 10032263 /api/author/10032263 Andrea Németh (immunológia) Németh Andrea true 10032263 true Nemeth A true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 24129098 true PersonAuthorship 7851558 /api/authorship/7851558 Sperlagh, B [Sperlágh, Beáta (Neurofarmakológia), author] Laboratory of Molecular Pharmacology (IEM / DP) 8 0.055555556 false false Author 10008942 /api/author/10008942 Beáta Sperlágh (Neurofarmakológia) Sperlágh Beáta true 10008942 true Sperlagh B true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 24129097 true PersonAuthorship 7851559 /api/authorship/7851559 Baranyai, T [Baranyai, Tamás (Kardiológia), author] Department of Pharmacology and Pharmacotherapy (SU / FM / I) 9 0.055555556 false false Author 10040912 /api/author/10040912 Tamás Baranyai (Kardiológia) Baranyai Tamás true 10040912 true Baranyai T true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 24129096 true PersonAuthorship 7851560 /api/authorship/7851560 Giricz, Z [Giricz, Zoltán (Biokémia, Farmako...), author] Department of Pharmacology and Pharmacotherapy (SU / FM / I) 10 0.055555556 false false Author 10026898 /api/author/10026898 Zoltán Giricz (Biokémia, Farmakológia) Giricz Zoltán true 10026898 true Giricz Z true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 24129095 true PersonAuthorship 7851561 /api/authorship/7851561 Wiener, Z [Wiener, Zoltán (Sejtbiológia, tum...), author] Department of Genetics, Cell- and Immunology (SU / FM / I) 11 0.055555556 false false Author 10012601 /api/author/10012601 Zoltán Wiener (Sejtbiológia, tumorbiológia) Wiener Zoltán true 10012601 true Wiener Z true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 24129094 true PersonAuthorship 7851562 /api/authorship/7851562 Turiak, L [Turiák, Lilla (tömegspektrometri...), author] Institute of Organic Chemistry (MTA TTK) 12 0.056 false false Author 10024570 /api/author/10024570 Lilla Turiák (tömegspektrometria, proteomika) Turiák Lilla true 10024570 true Turiak L true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 24129093 true PersonAuthorship 7851563 /api/authorship/7851563 Drahos, L [Drahos, László (proteomika, tömeg...), author] Institute of Organic Chemistry (MTA TTK) 13 0.055555556 false false Author 10002323 /api/author/10002323 László Drahos (proteomika, tömegspektrometria) Drahos László true 10002323 true Drahos L true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 24129092 true PersonAuthorship 7851564 /api/authorship/7851564 Pallinger, E [Pállinger, Éva (Immunológia), author] Department of Genetics, Cell- and Immunology (SU / FM / I) 14 0.055555556 false false Author 10015589 /api/author/10015589 Éva Pállinger (Immunológia) Pállinger Éva true 10015589 true Pallinger E true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 24129091 true PersonAuthorship 7851565 /api/authorship/7851565 Vekey, K [Vékey, Károly (Tömegspektrometria), author] Institute of Organic Chemistry (MTA TTK) 15 0.056 false false Author 10002353 /api/author/10002353 Károly Vékey (Tömegspektrometria) Vékey Károly true 10002353 true Vekey K true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 24129090 true PersonAuthorship 7851566 /api/authorship/7851566 Ferdinandy, P [Ferdinandy, Péter (Farmakológia, mol...), author] Department of Pharmacology and Pharmacotherapy (SU / FM / I) 16 0.055555556 false false Author 10010125 /api/author/10010125 Péter Ferdinandy (Farmakológia, molekuláris medicina) Ferdinandy Péter true 10010125 true Ferdinandy P true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 24129089 true PersonAuthorship 7851567 /api/authorship/7851567 Falus, A [Falus, András (Immunológia, geno...), author] Department of Genetics, Cell- and Immunology (SU / FM / I) 17 0.055555556 false false Author 10000001 /api/author/10000001 András Falus (Immunológia, genomika, egészségnevelés) Falus András true 10000001 true Falus A true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 24129088 true PersonAuthorship 7851568 /api/authorship/7851568 Buzas, EI ✉ [Buzás, Edit Irén (Immunbiológia), author] Department of Genetics, Cell- and Immunology (SU / FM / I) 18 0.056 false true true Author 10015596 /api/author/10015596 Edit Irén Buzás (Immunbiológia) Buzás Edit Irén true 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Committee on Sociology:A nemzetközi SCIENTIFIC REPORTS 2045-2322 RatingType 10007 /api/ratingtype/10007 IX. Committee on Sociology SZTB Institute 14102 /api/institute/14102 Committee on Sociology HASSELIX SZTB [1901-] 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19359 true MtaRating 11551161 /api/mtarating/11551161 IX. Committee on Regional Studies:B nemzetközi SCIENTIFIC REPORTS 2045-2322 RatingType 10010 /api/ratingtype/10010 IX. Committee on Regional Studies RegTB Institute 14100 /api/institute/14100 Committee on Regional Studies HASSELIX RTB [1901-] 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true B nemzetközi false true SjrRating 10950790 /api/sjrrating/10950790 sjr:D1 (2016) Scopus - Multidisciplinary SCIENTIFIC REPORTS 2045-2322 4 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 Scopus - Multidisciplinary true 1000 true D1 DIRECT true true /api/publication/3054080 Sodar BW et al. Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection. (2016) SCIENTIFIC REPORTS 2045-2322 6<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <a href="/gui2/?type=authors&mode=browse&sel=10043376" target="_blank">Sodar BW (Sódar Barbara immunológia) </a> SU/FM/I/Department of Genetics, Cell- and Immunology ;    <a href="/gui2/?type=authors&mode=browse&sel=10009113" target="_blank">Kittel A (Kittel Ágnes Sejtbiológia) </a> IEMHAS/DP/Laboratory of Molecular Pharmacology ;    <a href="/gui2/?type=authors&mode=browse&sel=10024466" target="_blank">Paloczi K (Pálóczi Krisztina immunológia, genetika) </a> SU/FM/I/Department of Genetics, Cell- and Immunology ;    <a href="/gui2/?type=authors&mode=browse&sel=10040711" target="_blank">Vukman KV (Visnovitzné Dr Vukman Krisztina biológia) </a> SU/FM/I/Department of Genetics, Cell- and Immunology ;    <a href="/gui2/?type=authors&mode=browse&sel=10052584" target="_blank">Osteikoetxea X (Osteikoetxea Xabier immunológia, genetika) </a> SU/FM/I/Department of Genetics, Cell- and Immunology ;    <a href="/gui2/?type=authors&mode=browse&sel=10027645" target="_blank">Szabo-Taylor K (Szabó-Taylor Katalin Immunológia) </a> SU/FM/I/Department of Genetics, Cell- and Immunology ;    <a href="/gui2/?type=authors&mode=browse&sel=10032263" target="_blank">Nemeth A (Németh Andrea immunológia) </a> SU/FM/I/Department of Genetics, Cell- and Immunology ;    <a href="/gui2/?type=authors&mode=browse&sel=10008942" target="_blank">Sperlagh B (Sperlágh Beáta Neurofarmakológia) </a> IEMHAS/DP/Laboratory of Molecular Pharmacology ;    <a href="/gui2/?type=authors&mode=browse&sel=10040912" target="_blank">Baranyai T (Baranyai Tamás Kardiológia) </a> SU/FM/I/Department of Pharmacology and Pharmacotherapy ;    <a href="/gui2/?type=authors&mode=browse&sel=10026898" target="_blank">Giricz Z (Giricz Zoltán Biokémia, Farmakológia) </a> SU/FM/I/Department of Pharmacology and Pharmacotherapy ;    <a href="/gui2/?type=authors&mode=browse&sel=10012601" target="_blank">Wiener Z (Wiener Zoltán Sejtbiológia, tumorbiológia) </a> SU/FM/I/Department of Genetics, Cell- and Immunology ;    <a href="/gui2/?type=authors&mode=browse&sel=10024570" target="_blank">Turiak L (Turiák Lilla tömegspektrometria, proteomika) </a> MTA TTK/Institute of Organic Chemistry ;    <a href="/gui2/?type=authors&mode=browse&sel=10002323" target="_blank">Drahos L (Drahos László proteomika, tömegspektrometria) </a> MTA TTK/Institute of Organic Chemistry ;    <a href="/gui2/?type=authors&mode=browse&sel=10015589" target="_blank">Pallinger E (Pállinger Éva Immunológia) </a> SU/FM/I/Department of Genetics, Cell- and Immunology ;    <a href="/gui2/?type=authors&mode=browse&sel=10002353" target="_blank">Vekey K (Vékey Károly Tömegspektrometria) </a> MTA TTK/Institute of Organic Chemistry ;    <a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy P (Ferdinandy Péter Farmakológia, molekuláris medicina) </a> SU/FM/I/Department of Pharmacology and Pharmacotherapy ;    <a href="/gui2/?type=authors&mode=browse&sel=10000001" target="_blank">Falus A (Falus András Immunológia, genomika, egészségnevelés) </a> SU/FM/I/Department of Genetics, Cell- and Immunology ;    <a href="/gui2/?type=authors&mode=browse&sel=10015596" target="_blank">Buzas EI ✉ (Buzás Edit Irén Immunbiológia) </a> SU/FM/I/Department of Genetics, Cell- and Immunology </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3054080" target="_blank">Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection</a></div> <div> SCIENTIFIC REPORTS ( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>): 6 Paper 24316. 12 p. (2016) </div> <div class="pub-footer"> Language: English | <a style="color:blue" title="10.1038/srep24316" target="_blank" href="https://doi.org/10.1038/srep24316"> DOI </a> <a style="color:blue" title="6017" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/6017"> SE Repozitórium </a> <a style="color:blue" title="000374226600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000374226600001"> WoS </a> <a style="color:blue" title="84963964100" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84963964100"> Scopus </a> <a style="color:blue" title="27087061" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27087061&dopt=Abstract"> PubMed </a> <a style="color:blue" title="PMC4834552" target="_blank" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834552"> Pubmed Central </a> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary   Rank: D1</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]   A nemzetközi</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]   B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> Citing papers: 515 | Independent citation: 485 | Self citation: 30 | Unknown citation: 0 | Number of citations in WoS: 487 | Number of citations in Scopus: 495 | WoS/Scopus assigned: 504 | Number of citations with DOI: 501 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3054080&sort=publishedYear,desc&sort=title"> Number of cited publications: 13 </a> </div> <div class="mtid">Publication: 3054080 | Validated Old id: 3054080 | Core Citing | Journal Article ( Article ) | Scientific | MEDLINE </div> <div class="lastModified">Last Modified: 2026.02.11. 15:14 András Balázs (MTMT Központ, admin) </div> <div class="lockedBy">Centrally managed 2026.01.21. 14:12 Katalin Mikola (MTMT 3, admin) </div> </div></div>