Thyroid hormones and obesity: a known but poorly understood relationship

Garcia-Solis, Pablo; Garcia, Olga P.; Hernandez-Puga, Gabriela; Sanchez-Tusie, Ana A.; Saenz-Luna, Carlos E.; Hernandez-Montiel, Hebert L.; Solis-S, Juan C.

Angol nyelvű Tudományos Összefoglaló cikk (Folyóiratcikk)
Megjelent: ENDOKRYNOLOGIA POLSKA 0423-104X 69 (3) pp. 292-303 2018
  • SJR Scopus - Endocrinology: Q3
    Thyroid hormones (TH) are involved in a wide variety of biological processes, including neurodevelopment, regulation of intermediary metabolism, and energy expenditure. TH actively participate in basal energy expenditure and adaptive thermogenesis, and for this reason body weight can be affected during dysthyroidism. Obesity is a non-transmissible, chronic, inflammatory, metabolic disease that implies a positive energy balance. The adipose tissue produces a series of hormones and adipocytokines such as leptin, which can influence the thyroid status at different levels. There is evidence showing that thyroid dysfunction could predispose to obesity; conversely, there is also evidence suggesting that obesity induces thyroidal alterations. The aim of this review is to describe the relation between the thyroidal system and obesity; in addition, we present a hypothetical model highlighting the importance of TH peripheral deiodination and its role in the establishment of a positive energy balance. We conclude that the relation between the thyroid system and obesity and overweight is complex and involves multiple levels of interaction. In addition, the assessment of the obese patient should consider an evaluation of the thyroidal function in order to achieve a better and personalised treatment for these patients.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2021-03-09 03:25