https://m2.mtmt.hu/ eng 2026-10-22 21:08 JournalArticle 3049855 VALIDATED true 0 2018-01-04T13:01:25.000+0000 false 3049855 2026-10-17T16:26:24.905+0000 2024-12-14T11:47:44.617+0000 2016-04-13T06:09:26.000+0000 true 10012934 Dénes Ádám /api/author/10012934 Author true 10012934 2026-10-13T10:02:51.428+0000 2026-10-13T10:02:51.428+0000 2024-12-14T11:47:44.993+0000 true 10003134 Wolf György /api/admin/10003134 Admin true 10003134 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10080106 /api/admin/10080106 Király Magdolna true true 2024-10-17T16:46:05.635+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Egri, P Pituitary adenylate cyclase-activating polypeptide (PACAP) regulates the hypothalamo-pituitary-thyroid (HPT) axis via type 2 deiodinase in male mice. true true /api/journal/1410 REVIEWED true false 1410 false 1410 true 0013-7227 1945-7170 Journal FOREIGN 157 6 2356 2366 2356 11 2016 The hypothalamic activation of thyroid hormones by type 2 deiodinase (D2), catalyzing the conversion of thyroxine to T3, is critical for the proper function of the hypothalamo-pituitary-thyroid (HPT) axis. Regulation of D2 expression in tanycytes alters the activity of the HPT axis. However, signals that regulate D2 expression in tanycytes are poorly understood. The pituitary adenylate cyclase-activating polypeptide (PACAP) increases intracellular cAMP level, a second messenger known to stimulate the DIO2 gene however its importance in tanycytes is not completely characterized. Therefore, we tested whether this ubiquitously expressed neuropeptide regulates the HPT axis through stimulation of D2 in tanycytes. PACAP increased the activity of human DIO2 promoter in luciferase reporter assay that was abolished by mutation of cAMP-response element. Furthermore, PAC1R receptor immunoreactivity was identified in hypothalamic tanycytes suggesting that these D2-expressing cells could be regulated by PACAP. Intracerebroventricular PACAP administration resulted in increased D2 activity in the mediobasal hypothalamus, suppressed Trh expression in the hypothalamic paraventricular nucleus, and decreased Tshb expression in the pituitary demonstrating that PACAP affects the D2-mediated control of the HPT axis. To understand the role of endogenous PACAP in the regulation of HPT axis, the effect of decreased PACAP expression was studied in heterozygous Adcyap1 (PACAP) knock out mice. These animals were hypothyroid that may be the consequence of altered hypothalamic T3 degradation during set-point formation of the HPT axis. In conclusion, PACAP is an endogenous regulator of the HPT axis by affecting T3-mediated negative feedback via cAMP-induced D2 expression of tanycytes. true true 2016 434076 true true true false true false GOLD 2026-10-17 true https://doi.org/10.1210/en.2016-1043 true 10039736 xRadó Nikolett /api/admin/10039736 Admin true 10039736 24 0 24 12 11 24 23 24 23 24 24 12 12 12 12 0 24 12 24 12 0 23 23 Folyóiratcikk Journal Article 24 24 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2016 0 2 1 2 1 2017 0 4 3 4 3 2018 0 4 0 4 0 2019 0 2 0 2 0 2020 0 3 2 3 2 2021 0 3 2 3 2 2022 0 2 1 2 1 2023 0 1 0 1 0 2024 0 2 2 2 2 2025 0 1 1 1 1 Q1 false 206 false false false 2018-01-04T12:58:00.000+0000 2016-04-13T06:14:06.000+0000 Anatómiai Intézet (PTE / ÁOK); Doktori Iskola (SE); Integratív Neuroendokrinológiai Kutatócsoport (HRN KOKI); Molekuláris Sejt Metabolizmus Kutatócsoport (HRN KOKI); Neuroimmunológiai Kutatócsoport (HRN KOKI) 6 42 5 7 0 true 10080106 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 7836786 /api/authorship/7836786 1 0.143 true false Author 206 /api/author/206 Egri Péter true 206 true Egri P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24094249 true PersonAuthorship 7836787 /api/authorship/7836787 2 0.14285715 false false Author 10012354 /api/author/10012354 Fekete Csaba true 10012354 true Fekete C true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24094248 true PersonAuthorship 7836788 /api/authorship/7836788 3 0.14285715 false false Author 10012934 /api/author/10012934 Dénes Ádám true 10012934 true Denes A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24094247 true PersonAuthorship 7836789 /api/authorship/7836789 4 0.14285715 false false Author 10001467 /api/author/10001467 Reglődi Dóra true 10001467 true Reglodi D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24094246 true PersonAuthorship 7836790 /api/authorship/7836790 5 0.14285715 false false Hashimoto H true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24094245 true PersonAuthorship 7836791 /api/authorship/7836791 6 0.14285715 false false Author 10039250 /api/author/10039250 Fülöp Balázs Dániel true 10039250 true Fulop BD true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24094244 true PersonAuthorship 7836792 /api/authorship/7836792 7 0.143 false true true Author 10011473 /api/author/10011473 Gereben Balázs true 10011473 true Gereben B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24094243 true PublicationIdentifier 1088920 /api/publicationidentifier/1088920 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1210/en.2016-1043 https://doi.org/10.1210/en.2016-1043 false 1344533 true PublicationIdentifier 1088918 /api/publicationidentifier/1088918 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000377214600016 https://www.webofscience.com/wos/woscc/full-record/000377214600016 false 1392474 true PublicationIdentifier 1088919 /api/publicationidentifier/1088919 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84974577137 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84974577137 false 1393514 true PublicationIdentifier 1088921 /api/publicationidentifier/1088921 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 27046436 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27046436&dopt=Abstract false 1344534 true Classification 10545 /api/classification/10545 true true Classification 12215 /api/classification/12215 true true SjrRating 10931074 /api/sjrrating/10931074 14 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1310 /api/classificationexternal/1310 true 1310 true Q1 DIRECT true true /api/publication/3049855 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="206"><a href="/gui2/?type=authors&mode=browse&sel=206" target="_blank">Egri P (<span class="authorship-author-name">Egri Péter</span> <span class="authorAux-mtmt"> Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of Ph. D. Studies; <span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Molecular Cell Metabolism</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012354"><a href="/gui2/?type=authors&mode=browse&sel=10012354" target="_blank">Fekete C (<span class="authorship-author-name">Fekete Csaba</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012934"><a href="/gui2/?type=authors&mode=browse&sel=10012934" target="_blank">Denes A (<span class="authorship-author-name">Dénes Ádám</span> <span class="authorAux-mtmt"> Neurobiológia, neuroimmunológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Molekuláris és Fejlődés Neurobiológia Osztály">MFNO</span>/Laboratory of Neuroimmunology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001467"><a href="/gui2/?type=authors&mode=browse&sel=10001467" target="_blank">Reglodi D (<span class="authorship-author-name">Reglődi Dóra</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Anatomy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hashimoto H </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10039250"><a href="/gui2/?type=authors&mode=browse&sel=10039250" target="_blank">Fulop BD (<span class="authorship-author-name">Fülöp Balázs Dániel</span> <span class="authorAux-mtmt"> Orvosi alapkutatások</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Anatomy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011473"><a href="/gui2/?type=authors&mode=browse&sel=10011473" target="_blank">Gereben B ✉ (<span class="authorship-author-name">Gereben Balázs</span> <span class="authorAux-mtmt"> Pajzsmirigy endokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Molecular Cell Metabolism</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3049855" target="_blank">Pituitary adenylate cyclase-activating polypeptide (PACAP) regulates the hypothalamo-pituitary-thyroid (HPT) axis via type 2 deiodinase in male mice.</a></div> <div> <span class="journal-title">ENDOCRINOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0013-7227">0013-7227</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1945-7170">1945-7170</a>)</span>: <span class="journal-volume">157</span> <span class="journal-issue">6</span> <span class="page"> pp 2356-2366 </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1210/en.2016-1043" target="_blank" href="https://doi.org/10.1210/en.2016-1043"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000377214600016" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000377214600016"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84974577137" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84974577137"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="27046436" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27046436&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 24</span> | Independent citation: 12 | Self citation: 12 | Unknown citation: 0 | Number of citations in WoS: 24 | Number of citations in Scopus:&nbsp;23 | WoS/Scopus assigned:&nbsp;24 | Number of citations with DOI:&nbsp;23 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3049855&sort=publishedYear,desc&sort=title"> Number of cited publications: 23 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 3049855</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 3049855</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2024.12.14. 12:47 György Wolf (MTMT Központi admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:46 Gusztáv Ladányi (MTMT API user, admin) Magdolna Király (MTMT ellenőrzés admin5) </div> </div></div>