Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma

Menyhart, Otilia [Menyhart, Otilia (onkologia), szerző] II. Sz. Gyermekgyógyászati Klinika (SE / AOK / K); Onkológiai Biomarker Kutatócsoport (Lendület) (HRN TTK / MÉI); Nagy, Adam [Nagy, Ádám (biológia), szerző] II. Sz. Gyermekgyógyászati Klinika (SE / AOK / K); Gyorffy, Balazs ✉ [Győrffy, Balázs (Onkológia), szerző] II. Sz. Gyermekgyógyászati Klinika (SE / AOK / K); Onkológiai Biomarker Kutatócsoport (Lendület) (HRN TTK / MÉI)

Angol nyelvű Szakcikk (Folyóiratcikk) Tudományos
Megjelent: ROYAL SOCIETY OPEN SCIENCE 2054-5703 2054-5703 5 (12) Paper: 181006 , 17 p. 2018
  • Regionális Tudományok Bizottsága: B nemzetközi
  • Szociológiai Tudományos Bizottság: C nemzetközi
  • SJR Scopus - Multidisciplinary: D1
Azonosítók
Szakterületek:
  • Egyéb természettudományok
Background: Potential prognostic biomarker candidates for hepatocellular carcinoma (HCC) are abundant, but their generalizability is unexplored. We cross-validated markers of overall survival (OS) and vascular invasion in independent datasets. Methods: The literature search yielded 318 genes related to survival and 52 related to vascular invasion. Validation was performed in three datasets (RNA-seq, n = 371; Affymetrix arrays, n = 91; Illumina gene chips, n = 135) by uni-and multivariate Cox regression and Mann-Whitney U-test, separately for Asian and Caucasian patients. Results: One hundred and eighty biomarkers remained significant in Asian and 128 in Caucasian subjects at p <0.05. After multiple testing correction BIRC5 (p =1.9 x 10(-10)), CDC20 (p = 2.5 x 10(-9)) and PLK1 (p = 3 x 10(-9)) endured as best performing genes in Asian patients; however, none remained significant in the Caucasian cohort. In a multivariate analysis, significance was reached by stage (p = 0.0018) and expression of CENPH (p = 0.0038) and CDK4 (p = 0.038). KIF18A was the only gene predicting vascular invasion in the Affymetrix and Illumina cohorts ( p = 0.003 and p = 0.025, respectively). Conclusion: Overall, about half of biomarker candidates failed to retain prognostic value and none were better than stage predicting OS. Impact: Our results help to eliminate biomarkers with limited capability to predict OS and/or vascular invasion.
Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
2024-07-17 15:40