https://m2.mtmt.hu/ hun 2026-05-30 13:39 JournalArticle 3049309 VALIDATED true MTA-SE Lendulet Diabetes Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary MTA-SE Pediatrics and Nephrology Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary First Department of Pediatrics, Semmelweis University, Bókay János u. 53-54, Budapest, 1083, Hungary Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary Institute of Pathophysiology, Semmelweis University, Budapest, Hungary Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary Department of Pathology, Moritz Kaposi General Hospital, Kaposvar, Hungary Cited By :20 Export Date: 23 March 2021 CODEN: JASNE Correspondence Address: Fekete, A.; First Department of Pediatrics, Bókay János u. 53-54, Hungary; email: fekete.andrea@med.semmelweis-univ.hu MTA-SE Lendulet Diabetes Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary MTA-SE Pediatrics and Nephrology Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary First Department of Pediatrics, Semmelweis University, Bókay János u. 53-54, Budapest, 1083, Hungary Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary Institute of Pathophysiology, Semmelweis University, Budapest, Hungary Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary Department of Pathology, Moritz Kaposi General Hospital, Kaposvar, Hungary Cited By :21 Export Date: 15 April 2021 CODEN: JASNE Correspondence Address: Fekete, A.; First Department of Pediatrics, Bókay János u. 53-54, Hungary; email: fekete.andrea@med.semmelweis-univ.hu MTA-SE Lendulet Diabetes Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary MTA-SE Pediatrics and Nephrology Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary First Department of Pediatrics, Semmelweis University, Bókay János u. 53-54, Budapest, 1083, Hungary Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary Institute of Pathophysiology, Semmelweis University, Budapest, Hungary Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary Department of Pathology, Moritz Kaposi General Hospital, Kaposvar, Hungary Cited By :21 Export Date: 16 April 2021 CODEN: JASNE Correspondence Address: Fekete, A.; First Department of Pediatrics, Bókay János u. 53-54, Hungary; email: fekete.andrea@med.semmelweis-univ.hu MTA-SE Lendulet Diabetes Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary MTA-SE Pediatrics and Nephrology Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary First Department of Pediatrics, Semmelweis University, Bókay János u. 53-54, Budapest, 1083, Hungary Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary Institute of Pathophysiology, Semmelweis University, Budapest, Hungary Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary Department of Pathology, Moritz Kaposi General Hospital, Kaposvar, Hungary Cited By :21 Export Date: 16 April 2021 CODEN: JASNE Correspondence Address: Fekete, A.; First Department of Pediatrics, Bókay János u. 53-54, Hungary; email: fekete.andrea@med.semmelweis-univ.hu Chemicals/CAS: creatinine, 19230-81-0, 60-27-5; endothelial nitric oxide synthase, 503473-02-7; fluvoxamine, 54739-18-3; glyceraldehyde 3 phosphate dehydrogenase, 9001-50-7; neuronal nitric oxide synthase, 506430-87-1; nitric oxide, 10102-43-9; nitric oxide synthase, 125978-95-2; prasterone, 53-43-0; protein kinase B, 148640-14-6; Dehydroepiandrosterone; Fluvoxamine; Receptors, sigma; Serotonin Uptake Inhibitors; sigma-1 receptor Manufacturers: Sigma Aldrich; Sigma Aldrich, United States Funding details: Hungarian Scientific Research Fund, OTKA, K100909, K108655, K108688, K112629, LP-008/2015, NN114607, PD105361 Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: This study was funded by OTKA K112629, K108688, K100909, K108655, PD105361 and NN114607 grants of the Hungarian Scientific Research Fund and MTA-SE “Lendulet” Research Grant (LP-008/2015) of the Hungarian Academy of Sciences. MTA-SE Lendulet Diabetes Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary MTA-SE Pediatrics and Nephrology Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary First Department of Pediatrics, Semmelweis University, Bókay János u. 53-54, Budapest, 1083, Hungary Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary Institute of Pathophysiology, Semmelweis University, Budapest, Hungary Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary Department of Pathology, Moritz Kaposi General Hospital, Kaposvar, Hungary Cited By :22 Export Date: 6 September 2021 CODEN: JASNE Correspondence Address: Fekete, A.; First Department of Pediatrics, Bókay János u. 53-54, Hungary; email: fekete.andrea@med.semmelweis-univ.hu Funding Agency and Grant Number: OTKA of the Hungarian Scientific Research FundOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [K112629, K108688, K100909, K108655, PD105361, NN114607]; MTA-SE "Lendulet" Research Grant of the Hungarian Academy of Sciences [LP-008/2015] Funding text: This study was funded by OTKA K112629, K108688, K100909, K108655, PD105361 and NN114607 grants of the Hungarian Scientific Research Fund and MTA-SE "Lendulet" Research Grant (LP-008/2015) of the Hungarian Academy of Sciences. MTA-SE Lendulet Diabetes Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary MTA-SE Pediatrics and Nephrology Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary First Department of Pediatrics, Semmelweis University, Bókay János u. 53-54, Budapest, 1083, Hungary Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary Institute of Pathophysiology, Semmelweis University, Budapest, Hungary Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary Department of Pathology, Moritz Kaposi General Hospital, Kaposvar, Hungary Cited By :23 Export Date: 21 September 2021 CODEN: JASNE Correspondence Address: Fekete, A.; First Department of Pediatrics, Bókay János u. 53-54, Hungary; email: fekete.andrea@med.semmelweis-univ.hu Chemicals/CAS: creatinine, 19230-81-0, 60-27-5; endothelial nitric oxide synthase, 503473-02-7; fluvoxamine, 54739-18-3; glyceraldehyde 3 phosphate dehydrogenase, 9001-50-7; neuronal nitric oxide synthase, 506430-87-1; nitric oxide, 10102-43-9; nitric oxide synthase, 125978-95-2; prasterone, 53-43-0; protein kinase B, 148640-14-6; Dehydroepiandrosterone; Fluvoxamine; Receptors, sigma; Serotonin Uptake Inhibitors; sigma-1 receptor Manufacturers: Sigma Aldrich; Sigma Aldrich, United States Funding details: Hungarian Scientific Research Fund, OTKA, K100909, K108655, K108688, K112629, LP-008/2015, NN114607, PD105361 Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: This study was funded by OTKA K112629, K108688, K100909, K108655, PD105361 and NN114607 grants of the Hungarian Scientific Research Fund and MTA-SE “Lendulet” Research Grant (LP-008/2015) of the Hungarian Academy of Sciences. 0 2018-09-27T08:10:32.000+0000 false 3049309 2026-05-22T12:15:01.786+0000 2022-02-17T08:44:01.321+0000 2016-04-12T08:22:18.000+0000 true 10012934 Dénes Ádám /api/author/10012934 Author true 10012934 2026-02-10T12:52:34.686+0000 2026-02-10T12:52:34.686+0000 2019-07-26T10:40:43.090+0000 true 10063747 Szepesi Dóra Anna /api/admin/10063747 Admin true 10063747 2022-02-17T08:44:01.334+0000 true 10074925 Olasz Tamás /api/admin/10074925 Admin true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10080106 /api/admin/10080106 Király Magdolna true true 2024-10-17T16:46:05.635+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Hosszu, A Sigma1-Receptor Agonism Protects against Renal Ischemia-Reperfusion Injury true true /api/journal/2227 REVIEWED true false 2227 false 2227 true 1046-6673 1533-3450 Journal FOREIGN 28 1 152 165 152 14 2017 Mechanisms of renal ischemia-reperfusion injury remain unresolved, and effective therapies are lacking. We previously showed that dehydroepiandrosterone protects against renal ischemia-reperfusion injury in male rats. Here, we investigated the potential role ofsigma1-receptor activation in mediating this protection. In rats, pretreatment with either dehydroepiandrosterone or fluvoxamine, a high-affinitysigma1-receptor agonist, improved survival, renal function and structure, and the inflammatory response after sublethal renal ischemia-reperfusion injury. In human proximal tubular epithelial cells, stimulation by fluvoxamine or oxidative stress caused thesigma1-receptor to translocate from the endoplasmic reticulum to the cytosol and nucleus. Fluvoxamine stimulation in these cells also activated nitric oxide production that was blocked bysigma1-receptor knockdown or Akt inhibition. Similarly, in the postischemic rat kidney,sigma1-receptor activation by fluvoxamine triggered the Akt-nitric oxide synthase signaling pathway, resulting in time- and isoform-specific endothelial and neuronal nitric oxide synthase activation and nitric oxide production. Concurrently, intravital two-photon imaging revealed prompt peritubular vasodilation after fluvoxamine treatment, which was blocked by thesigma1-receptor antagonist or various nitric oxide synthase blockers. In conclusion, in this rat model of ischemia-reperfusion injury,sigma1-receptor agonists improved postischemic survival and renal functionviaactivation of Akt-mediated nitric oxide signaling in the kidney. 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/api/classification/12215 true true SjrRating 10971889 /api/sjrrating/10971889 42 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true D1 DIRECT true true /api/publication/3049309 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10032730"><a href="/gui2/?type=authors&mode=browse&sel=10032730" target="_blank">Hosszu A (<span class="authorship-author-name">Hosszú Ádám</span> <span class="authorAux-mtmt"> nephrológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/I. Sz. Gyermekgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="I. Sz. Gyermekgyógyászati Klinika">ISZGYK</span>/MTA-SE Lendület Diabétesz Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024419"><a href="/gui2/?type=authors&mode=browse&sel=10024419" target="_blank">Antal Z (<span class="authorship-author-name">Antal Zsuzsanna</span> <span class="authorAux-mtmt"> gyermeksebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/I. Sz. Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032773"><a href="/gui2/?type=authors&mode=browse&sel=10032773" target="_blank">Lenart L (<span class="authorship-author-name">Lénárt Lilla</span> <span class="authorAux-mtmt"> nephrológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="I. Sz. Gyermekgyógyászati Klinika">ISZGYK</span>/MTA-SE Lendület Diabétesz Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032759"><a href="/gui2/?type=authors&mode=browse&sel=10032759" target="_blank">Hodrea J (<span class="authorship-author-name">Hodrea Judit</span> <span class="authorAux-mtmt"> szemészet, diabetológia, nephrologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="I. Sz. Gyermekgyógyászati Klinika">ISZGYK</span>/MTA-SE Lendület Diabétesz Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027412"><a href="/gui2/?type=authors&mode=browse&sel=10027412" target="_blank">Koszegi S (<span class="authorship-author-name">Kőszegi Sándor</span> <span class="authorAux-mtmt"> diabetes, molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="I. Sz. Gyermekgyógyászati Klinika">ISZGYK</span>/MTA-SE Lendület Diabétesz Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052792"><a href="/gui2/?type=authors&mode=browse&sel=10052792" target="_blank">Balogh DB (<span class="authorship-author-name">Balogh Dóra Bianka</span> <span class="authorAux-mtmt"> Molekuláris biológia. Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="I. Sz. Gyermekgyógyászati Klinika">ISZGYK</span>/MTA-SE Lendület Diabétesz Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020755"><a href="/gui2/?type=authors&mode=browse&sel=10020755" target="_blank">Banki NF (<span class="authorship-author-name">Bánki Nóra Fanni</span> <span class="authorAux-mtmt"> nefrológus</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/I. Sz. Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020375"><a href="/gui2/?type=authors&mode=browse&sel=10020375" target="_blank">Wagner L (<span class="authorship-author-name">Wágner László József</span> <span class="authorAux-mtmt"> Transzplantáció</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Transzplantációs és Sebészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012934"><a href="/gui2/?type=authors&mode=browse&sel=10012934" target="_blank">Denes A (<span class="authorship-author-name">Dénes Ádám</span> <span class="authorAux-mtmt"> Neurobiológia, neuroimmunológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">MTAKOKI</span>/<span title="Molekuláris és Fejlődés Neurobiológia Osztály">MFNO</span>/Neuroimmunológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000223"><a href="/gui2/?type=authors&mode=browse&sel=10000223" target="_blank">Hamar P (<span class="authorship-author-name">Hamar Péter</span> <span class="authorAux-mtmt"> Vese immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Kórélettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Degrell P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015708"><a href="/gui2/?type=authors&mode=browse&sel=10015708" target="_blank">Vannay A (<span class="authorship-author-name">Vannay Ádám</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="I. Sz. Gyermekgyógyászati Klinika">ISZGYK</span>/MTA-SE Gyermekgyógyászati és Nephrológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015517"><a href="/gui2/?type=authors&mode=browse&sel=10015517" target="_blank">Szabo AJ (<span class="authorship-author-name">Szabó Attila</span> <span class="authorAux-mtmt"> Gyermekgyógyászat, nephrologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="I. Sz. Gyermekgyógyászati Klinika">ISZGYK</span>/MTA-SE Gyermekgyógyászati és Nephrológiai Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/I. Sz. Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011883"><a href="/gui2/?type=authors&mode=browse&sel=10011883" target="_blank">Fekete A ✉ (<span class="authorship-author-name">Fekete Andrea</span> <span class="authorAux-mtmt"> nefrológia, gyermekgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/I. Sz. Gyermekgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="I. Sz. Gyermekgyógyászati Klinika">ISZGYK</span>/MTA-SE Lendület Diabétesz Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3049309" target="_blank">Sigma1-Receptor Agonism Protects against Renal Ischemia-Reperfusion Injury</a></div> <div> <span class="journal-title">JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1046-6673">1046-6673</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1533-3450">1533-3450</a>)</span>: <span class="journal-volume">28</span> <span class="journal-issue">1</span> <span class="page"> pp 152-165 </span> <span class="year">(2017)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="10.1681/ASN.2015070772" target="_blank" href="https://doi.org/10.1681/ASN.2015070772"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="4073" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/4073"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000391647700019" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000391647700019"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="211628" target="_blank" href="http://real.mtak.hu/211628"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85021851122" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85021851122"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="27056295" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27056295&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Nephrology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 66</span> | Független: 56 | Függő: 10 | Nem jelölt: 0 | WoS jelölt: 54 | Scopus jelölt:&nbsp;55 | WoS/Scopus jelölt:&nbsp;59 | DOI jelölt:&nbsp;60 (Nem nyilvános:&nbsp;1) </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3049309&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 11 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3049309</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3049309</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2022.02.17. 09:44 Olasz Tamás (SE_AOK_Transzlációs_Admin5_OT, admin) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:46 Ladányi Gusztáv (MTMT API user, admin) Király Magdolna (MTMT ellenőrzés admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: MTA-SE Lendulet Diabetes Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary MTA-SE Pediatrics and Nephrology Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary First Department of Pediatrics, Semmelweis University, Bókay János u. 53-54, Budapest, 1083, Hungary ...</pre> </div></div>