Montmorency cherry supplementation attenuates vascular dysfunction induced by prolonged forearm occlusion in overweight, middle-aged men

Bakkar, Zainie Aboo; Fuford, Jonathan; Gates, Phillip E.; Jackman, Sarah R.; Jones, Andrew M.; Bond, Bert; Bowtell, Joanna L.

Angol nyelvű Tudományos Szakcikk (Folyóiratcikk)
Megjelent: JOURNAL OF APPLIED PHYSIOLOGY 8750-7587 1522-1601 126 (1) pp. 246-254 2019
  • SJR Scopus - Medicine (miscellaneous): Q1
    Flavonoid supplementation improves brachial artery flow-mediated dilation (FMD), but it is not known whether flavonoids protect against vascular dysfunction induced by ischemia-reperfusion (IR) injury and associated respiratory burst. In a randomized, double-blind. placebo-controlled, crossover study, we investigated whether 4 wk supplementation with freeze-dried Montmorency cherry (MC) attenuated suppression of FMD after IR induced by prolonged forearm occlusion. Twelve physically inactive overweight, middle-aged men (52.8 +/- 5.8 yr, BMI: 28.1 +/- 5.3 kg/m(2)) consumed MC (235 mg/day anthocyanins) or placebo capsules for 4 wk. with supplementation blocks separated by 4 wk washout. Before and after each supplementation block, FMD responses and plasma nitrate and nitrite ([NO2-) concentrations were measured at baseline and 15, 30, and 45-min after prolonged (20 min) forearm occlusion. FMD response was significantly depressed by the prolonged occlusion (P < 0.001). After a 45-min reperfusion, FMD was restored to baseline levels after MC (Delta FMD presupplementation: -30.5 +/- 8.4%, postsupplementation: -0.6 +/- 9.5%) but not placebo supplementation (AMU presupplementation: -11.6 +/- 10.6, postsupplementation: - 25.4 +/- 4.0%; condition x supplement interaction: P = 0.038). Plasma [NOD decreased after prolonged occlusion but recovered faster after MC compared with placebo (045 min to baseline; MC: presupplcmcntation: - 15.3 +/- 9.6, postsupplementation: -6.2 +/- 8.1; Placebo: presupplementation: -163 +/- 5.9. postsupplementation: -27.7 +/- 11.1 nmol/l; condition x supplement x time interaction: P = 0.033). Plasma peroxiredoxin concentration ([Prx2]) was significantly higher after MC (presupplementation: 22.8 +/- 1.4, postsupplementation: 28.0 +/- 2.4 ng/ml, P = 0.029) but not after placebo supplementation (presupplementation: 22.1 +/- 2.2. postsupplementation: 23.7 +/- 1.5 ng/ml). In conclusion, 4 wk MC supplementation enhanced recovery of endothelium-dependent vasodilatation after IR, in parallel with faster recovery of plasma [NO2-], suggesting NO dependency. These protective effects seem to be related to increased plasma [Prx2], presumably conferring protection against the respiratory burst during reperfusion.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2020-08-14 16:42