{ "labelLang" : "eng", "responseDate" : "2024-03-28 12:53", "content" : { "otype" : "JournalArticle", "mtid" : 30474255, "status" : "VALIDATED", "published" : true, "comment" : "Funding Agency and Grant Number: FAPESP (Sao Paulo Research Foundation)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2017/18242-1, 2018/10362-0, 2018/03673-0]; Serrapilheira Institute [Serra-1709-16349]; CNPq (The Brazilian National Council for Scientific and Technological Development)National Council for Scientific and Technological Development (CNPq) [302453/2017-2]; CAPES (Coordination for the Improvement of Higher Education Personnel)CAPES [1656470, 1691474]\n Funding text: The authors thank FAPESP (Sao Paulo Research Foundation, grants 2017/18242-1, 2018/10362-0, and 2018/03673-0), Serrapilheira Institute (grant number Serra-1709-16349), and CNPq (The Brazilian National Council for Scientific and Technological Development, grant 302453/2017-2) for funding. We also thank CAPES (Coordination for the Improvement of Higher Education Personnel), for the scholarships (1656470 and 1691474).\nExport Date: 31 December 2019 \n CODEN: PROTC \n Correspondence Address: de Almeida, V.; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP)Brazil; email: val_farmac@yahoo.com.br\nLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil \n Instituto Nacional de Biomarcadores em Neuropsiquiatria (INBION) Conselho Nacional de Desenvolvimento Científico e Tecnológico, São Paulo, Brazil \n Export Date: 3 April 2020 \n CODEN: PROTC \n Correspondence Address: de Almeida, V.; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP)Brazil; email: val_farmac@yahoo.com.br \n Chemicals/CAS: lipid, 66455-18-3; 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Endocannabinoids are crucial neuromodulators of many brain functions and changes in the ligands and their receptors have been associated with psychiatric disorders, such as schizophrenia. Genetic, neuroimaging, and behavioral studies have reinforced the role of endocannabinoids in the pathobiology of schizophrenia. However, molecular pathways and biological processes involved in cannabinoid effects are not totally understood. Additionally, the endocannabinoid signaling network with other non-cannabinoid targets, and the effects of phytocannabinoids increase the complexity to understand their role in schizophrenia and homeostasis conditions. Thus, proteomic studies can provide evidence about the involvement of cannabinoid receptors, as well as the metabolic and synthetic enzymes of the endocannabinoids in these disorders. Additionally, quantification of endocannabinoids in the blood serum or cerebrospinal fluid can be a useful approach to identify new biomarkers in schizophrenia, and lipidomic techniques can be used to quantify these compounds. Herein, the authors review proteomic and lipidomic studies that have been used for analysis of the endocannabinoid system in healthy and schizophrenia function. 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