Helix-loop-helix peptide foldamers and their use in the construction of hydrolase mimetics

Drewniak, Magda; Weglarz-Tomczak, Ewelina; Ozga, Katarzyna; Rudzinska-Szostak, Ewa; Macegoniuk, Katarzyna; Tomczak, Jakub M.; Bejger, Magdalena; Rypniewski, Wojciech; Berlicki, Lukasz

English Scientific Article (Journal Article)
Published: BIOORGANIC CHEMISTRY 0045-2068 1090-2120 81 pp. 356-361 2018
  • SJR Scopus - Drug Discovery: Q2
Identifiers
Subjects:
    De novo designed helix-loop-helix peptide foldamers containing cis-2-aminocyclopentanecarboxylic acid residues were evaluated for their conformational stability and possible use in enzyme mimetic development. The correlation between hydrogen bond network size and conformational stability was demonstrated through CD and NMR spectroscopies. Molecules incorporating a Cys/His/Glu triad exhibited enzyme-like hydrolytic activity.
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    2021-01-23 03:16