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"AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true } ], "title" : "Ceramic core@shell nanospheres as vaccine carriers", "firstPageOrInternalIdForSort" : "", "publishedYear" : 2018, "conference" : { "otype" : "Conference", "mtid" : 128640, "link" : "/api/conference/128640", "label" : "11th Conference on Colloid Chemistry 2018-05-28 [Eger, Magyarország]", "location" : [ { "otype" : "City", "mtid" : 10558, "link" : "/api/city/10558", "label" : "Eger, Magyarország", "partOf" : { "otype" : "Country", "mtid" : 10001, "link" : "/api/country/10001", "label" : "Magyarország", "published" : true, "oldId" : 1, "snippet" : true }, "published" : true, "oldId" : 1082005, "snippet" : true } ], "published" : true, "snippet" : true }, "abstractText" : "The need for new vaccines is evident, but avoiding side effects is crucial for patient compliance. To achieve this, new generation vaccines are being developed. They combine an antigen as a target with the inclusion of an immunostimulant to ensure the induction of immunity, rather than tolerance. \nNanoparticles (NPs) are also used as vaccine-delivery systems. With appropriate size and well-chosen injection they are prone to accumulate in immune cells. However, their successful integration into nanovaccines requires thorough analysis of the inorganic/organic interface. \nI aimed at the elaboration of new vaccine carrier nanosystems, characterized them first by routinely used analytical methods and then by the recently developed solution state NMR spectroscopy toolbox developed at Ghent University [1].\nThe synthesis of silica@zirconia core@shell nanoparticles was based on Stöber et al. and Kim and coworkers’ method [2, 3]. I decorated the surface of these ceramic NPs with model biomolecules and immune stimulators. The physico-chemical characterization of the particles was carried out using transmission electron microscopy, dynamic light scattering, zeta potential measurements, UV-visible and Fourier-transform infrared spectroscopies. The surface ligand structure was studied by NMR toolbox. Preliminary experiments on biological fate of the as-prepared NPs were carried out (blood stability tests, cell viability assays etc).", "digital" : null, "printed" : null, "sourceYear" : 2019, "foreignEdition" : false, "foreignLanguage" : true, "fullPublication" : false, "conferencePublication" : true, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2023-11-22", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "nationalOriginCitationCount" : 0, "foreignEditionCitationCount" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "wosScopusCitationCount" : 0, "wosScopusCitationCountWoOther" : 0, "wosScopusIndependentCitationCount" : 0, "wosScopusIndependentCitationCountWoOther" : 0, "independentCitationCount" : 0, "selfCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "citingPubCountWoOther" : 0, "independentCitingPubCountWoOther" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 0, "citedCount" : 0, "hasCitationDuplums" : false, "userChangeableUntil" : "2019-05-30T16:38:37.512+0000", "publishDate" : "2019-03-01T17:38:37.591+0000", "directInstitutesForSort" : "MTA-SE Molekuláris Biofizikai Kutatócsoport (SE / AOK / I / BSI)", "ownerAuthorCount" : 2, "ownerInstituteCount" : 23, "directInstituteCount" : 1, "authorCount" : 6, "contributorCount" : 0, "chapterCount" : 0, "fromCitation" : false, "hasQualityFactor" : false, "link" : "/api/publication/30452624", "label" : "Livia Naszályi Nagy et al. 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