{ "labelLang" : "hun", "responseDate" : "2024-03-29 05:59", "content" : { "otype" : "JournalArticle", "mtid" : 30450796, "status" : "APPROVED", "published" : true, "comment" : "Institute of Neurobiology, Faculty of Mathematics and Natural Sciences, Heinrich Heine University Duesseldorf, Universitaetsstrasse 1, Duesseldorf, D-40225, Germany \n German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, Bonn, Germany \n Department of Neurology, University Hospital Bonn, Sigmund-Freud-Str. 25, Bonn, Germany \n Cited By :15 \n Export Date: 6 April 2021 \n CODEN: CECOE \n Correspondence Address: Rose, C.R.; Institute of Neurobiology, Universitaetsstrasse 1, Germany; email: rose@uni-duesseldorf.de\nFunding Agency and Grant Number: German Research Foundation (DFG)German Research Foundation (DFG) [SPP1757, Ro2327/8-1, PE1193/2-1]; Else Kroener-Fresenius Foundation; European Union (EU) Joint Program-Neurodegenerative Disease Research (JPND) program (EU Horizon 2020 Research and Innovation Program) [643417/DACAPO-AD]; DZNEHelmholtz Association\n Funding text: CRR received funding from the German Research Foundation (DFG; SPP1757 \"Glial Heterogeneity\", Ro2327/8-1). 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In the surrounding penumbra, cells may recover upon reperfusion, but recovery is hampered by additional metabolic demands imposed by peri-infarct depolarizations (PIDs). There is evidence that sodium influx drives PIDs, but no data exist on PID-related sodium accumulations in vivo. Here, we found that PIDs in mouse neocortex are associated with propagating sodium elevations in neurons and astrocytes. Similar transient sodium elevations were induced in acute tissue slices by brief chemical ischemia. Blocking NMDA-receptors dampened sodium and accompanying calcium loads of neurons in tissue slices, while inhibiting glutamate transport diminished sodium influx into astrocytes, but amplified neuronal sodium loads. In both cell types, inhibition of sodium/calcium exchange (NCX) increased sodium transients. Blocking NCX also significantly reduced calcium transients, a result confirmed in vivo. Our study provides the first quantitative data on sodium elevations in peri-infarct regions in vivo. They suggest that sodium influx drives reversal of NCX, triggering a massive secondary calcium elevation while promoting export of sodium. 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