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Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration
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Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese conductance through calcium-permeable channels, MEMRI applications expanded to include functional imaging in the central nervous system (CNS) and other body systems. MEMRI has since been employed in the investigation of physiology in many animal models and in humans. Here, we review historical perspectives that follow the evolution of applied MRI research into MEMRI with particular focus on its potential toxicity. Furthermore, we discuss the more current in vivo investigative uses of MEMRI in CNS investigations and the brief but decorated clinical usage of chelated manganese compound mangafodipir in humans.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Cloyd, Ryan A. </span> <span class="author-type"> </span> ; <span class="author-name" > Koren, Shon A. </span> <span class="author-type"> </span> ; <span class="author-name" > Abisambra, Jose F. </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;30416132" mtid="30416132" target="_blank">Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration</a></div> <div class="pub-info"> <span class="journal-title">FRONTIERS IN AGING NEUROSCIENCE</span> <span class="journal-volume">10</span> <span class="page"> Paper: 403 </span> <span class="year">(2018)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3389/fnagi.2018.00403" target="_blank" href="https://doi.org/10.3389%2Ffnagi.2018.00403"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000453325700002" target="_blank" href="http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=000453325700002&DestApp=WOS"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85071497138" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85071497138"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="30618710" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30618710&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:30416132 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core"> Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> </div> </div> </div><div class="JournalArticle Publication long-list">
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<span class="author-name" >Koren Shon A.
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<span class="author-name" >Abisambra Jose F.
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;30416132" target="_blank">Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration</a></div> <div> <span class="journal-title">FRONTIERS IN AGING NEUROSCIENCE</span>
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<div class="lastModified">Utolsó módosítás: 2019.01.31. 08:22 Milánkovics Róbert (PTE ÁOK admin 4)
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 3 August 2022</pre>
</div></div>