https://m2.mtmt.hu/ eng 2026-10-24 04:19 JournalArticle 30412530 APPROVED true 0 false 2026-10-19T11:21:25.792+0000 2025-04-25T09:55:16.450+0000 2019-01-28T12:45:25.997+0000 true 10065463 Turek Márta /api/admin/10065463 Admin true 2026-05-19T11:37:24.863+0000 2026-05-19T11:37:24.863+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Hrabovszky, Erik New perspectives for anatomical and molecular studies of kisspeptin neurons in the aging human brain true true /api/journal/3350 REVIEWED true false 3350 false 3350 true 0028-3835 1423-0194 Journal FOREIGN 109 3 230 241 230 12 2019 The human infundibular nucleus (corresponding to the rodent arcuate nucleus) serves as an important integration center for neuronal signals and hormones released by peripheral endocrine organs. Kisspeptin (KP) producing neurons of this anatomical site many of which also synthesize neurokinin B (NKB) are critically involved in sex hormone signaling to gonadotropin-releasing homone (GnRH) neurons. In recent years, the basic topography, morphology, neuropeptide content and connectivity of human KP neurons have been investigated with in situ hybridization and immunohistochemistry on post mortem tissues. These studies revealed that human KP neurons differ neurochemically from their rodent counterparts and show robust aging-related plasticity. Earlier immunohistochemical experiments also provided evidence for temporal changes in the hypothalamus of aging men whose NKB and KP neurons undergo hypertrophy, increase in number, exhibit increased neuropeptide mRNA expression and immunoreactivity and give rise to higher numbers of immunoreactive fibers and afferent contacts onto GnRH neurons. Increasing percentages of KP-expressing NKB perikarya, NKB axons and NKB inputs to GnRH neurons raise the intriguing possibility that a significant subset of NKB neurons begins to co-synthesize KP as aging proceeds. Although use of post mortem tissues is technically challenging, recently-available single-cell anatomical and molecular approaches discussed in this review article provide promising new tools to investigate the aging-related anatomical and functional plasticity of the human KP neuronal system.. Funding 1973192 /api/funding/1973192 false true Funding 1973193 /api/funding/1973193 false true true true 2019 true true true false true false GREEN 2026-10-19 true https://doi.org/10.1159/000496566 24 0 24 21 4 24 24 21 22 24 24 21 21 21 3 0 24 21 24 21 0 14 14 Folyóiratcikk Journal Article 24 23 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2019 0 2 2 2 2 2020 0 2 1 2 1 2021 0 8 6 8 6 2022 0 7 7 7 7 2023 0 1 1 1 1 2024 0 2 2 2 2 2025 0 2 2 2 2 D1 false false false false 2019-04-28T12:41:12.224+0000 2019-01-28T13:41:12.290+0000 Reproduktív Neurobiológia Laboratórium (HRN KOKI) 4 22 1 4 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 85088990 /api/authorship/85088990 1 0.25 true false Author 10011472 /api/author/10011472 Hrabovszky Erik true 10011472 true Hrabovszky Erik true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 85088991 /api/authorship/85088991 2 0.25 false false Author 10028898 /api/author/10028898 Takács Szabolcs Ferenc true 10028898 true Takács Szabolcs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 85088992 /api/authorship/85088992 3 0.25 false false Author 10062868 /api/author/10062868 Göcz Balázs Gergő true 10062868 true Göcz Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 85088993 /api/authorship/85088993 4 0.25 false true Author 10020450 /api/author/10020450 Skrapits Katalin true 10020450 true Skrapits Katalin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 15157764 /api/publicationidentifier/15157764 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GREEN true IDENTICAL 10.1159/000496566 https://doi.org/10.1159/000496566 false true PublicationIdentifier 15966474 /api/publicationidentifier/15966474 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GREEN true 102212 https://real.mtak.hu/102212 false true PublicationIdentifier 17647594 /api/publicationidentifier/17647594 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30612127&dopt=Abstract false true Classification 12125 /api/classification/12125 true true Classification 10545 /api/classification/10545 true true Classification 12347 /api/classification/12347 true true Classification 12548 /api/classification/12548 true true Keyword 962 /api/keyword/962 true 962 true Keyword 2565 /api/keyword/2565 true 2565 true Keyword 3010 /api/keyword/3010 true 3010 true Keyword 1036843 /api/keyword/1036843 true 1036843 true Keyword 1185581 /api/keyword/1185581 true 1185581 true Keyword 1518974 /api/keyword/1518974 true true Keyword 2373925 /api/keyword/2373925 true true SjrRating 10796973 /api/sjrrating/10796973 22 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2712 /api/classificationexternal/2712 true 2712 true D1 DIRECT true true /api/publication/30412530 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10011472"><a href="/gui2/?type=authors&mode=browse&sel=10011472" target="_blank">Hrabovszky Erik (<span class="authorship-author-name">Hrabovszky Erik</span> <span class="authorAux-mtmt"> Reproduktív endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Reproductive Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028898"><a href="/gui2/?type=authors&mode=browse&sel=10028898" target="_blank">Takács Szabolcs (<span class="authorship-author-name">Takács Szabolcs Ferenc</span> <span class="authorAux-mtmt"> neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Reproductive Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10062868"><a href="/gui2/?type=authors&mode=browse&sel=10062868" target="_blank">Göcz Balázs (<span class="authorship-author-name">Göcz Balázs Gergő</span> <span class="authorAux-mtmt"> Reproduktív neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Reproductive Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020450"><a href="/gui2/?type=authors&mode=browse&sel=10020450" target="_blank">Skrapits Katalin (<span class="authorship-author-name">Skrapits Katalin</span> <span class="authorAux-mtmt"> neuroendokrinológia/reproduktív neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Reproductive Neurobiology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30412530" target="_blank">New perspectives for anatomical and molecular studies of kisspeptin neurons in the aging human brain</a></div> <div> <span class="journal-title">NEUROENDOCRINOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-3835">0028-3835</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1423-0194">1423-0194</a>)</span>: <span class="journal-volume">109</span> <span class="journal-issue">3</span> <span class="page"> pp 230-241 </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="10.1159/000496566" target="_blank" href="https://doi.org/10.1159/000496566"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="102212" target="_blank" href="https://real.mtak.hu/102212"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000539044000006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000539044000006"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85072153832" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85072153832"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="30612127" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30612127&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Endocrine and Autonomic Systems&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 24</span> | Independent citation: 21 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 21 | Number of citations in Scopus:&nbsp;22 | WoS/Scopus assigned:&nbsp;24 | Number of citations with DOI:&nbsp;24 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30412530&sort=publishedYear,desc&sort=title"> Number of cited publications: 14 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 30412530</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> National Science Foundation of Hungary(K112669 and K128317), Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002) </div> <div class="lastModified">Last Modified: 2025.04.25. 11:55 Márta Turek (KOKI admin 4) </div> </div></div>