https://m2.mtmt.hu/ hun 2026-10-24 07:08 JournalArticle 3040810 ADMIN_APPROVED true Department of Developmental and Molecular Biology, Bronx, NY 10461, United States Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, United States Office for Subsidized Research Units, Hungarian Academy of Sciences (HAS), Budapest, H-1051, Hungary Institute of Genetics, Biological Research Centre, HAS, Szeged, H-6726, Hungary Cited By :4 Export Date: 21 January 2021 CODEN: GENTA Correspondence Address: Jenny, A.; Albert Einstein College of Medicine, Chanin 503, 1300 Morris Park Ave., United States; email: andreas.jenny@einstein.yu.edu 0 2018-10-02T08:54:25.000+0000 false 3040810 2026-10-21T09:32:55.309+0000 2020-12-05T17:13:06.497+0000 2016-03-22T11:09:02.000+0000 true 10010519 Mihály József /api/author/10010519 Author true 10010519 2025-09-05T07:10:23.597+0000 2017-02-09T10:46:41.000+0000 true 10018677 Berkes Kata /api/admin/10018677 Admin true 10018677 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Dollar, G Unique and Overlapping Functions of Formins Frl and DAAM During Ommatidial Rotation and Neuronal Development in Drosophila. true true /api/journal/1681 REVIEWED true false 1681 false 1681 true 0016-6731 1943-2631 Journal FOREIGN 202 3 1135 1151 1135 17 2016 The noncanonical Frizzled/planar cell polarity (PCP) pathway regulates establishment of polarity within the plane of an epithelium to generate diversity of cell fates, asymmetric, but highly aligned structures, or to orchestrate the directional migration of cells during convergent extension during vertebrate gastrulation. In Drosophila, PCP signaling is essential to orient actin wing hairs and to align ommatidia in the eye, in part by coordinating the movement of groups of photoreceptor cells during ommatidial rotation. Importantly, the coordination of PCP signaling with changes in the cytoskeleton is essential for proper epithelial polarity. Formins polymerize linear actin filaments and are key regulators of the actin cytoskeleton. Here, we show that the diaphanous-related formin, Frl, the single fly member of the FMNL (formin related in leukocytes/formin-like) formin subfamily affects ommatidial rotation in the Drosophila eye and is controlled by the Rho family GTPase Cdc42. Interestingly, we also found that frl mutants exhibit an axon growth phenotype in the mushroom body, a center for olfactory learning in the Drosophila brain, which is also affected in a subset of PCP genes. Significantly, Frl cooperates with Cdc42 and another formin, DAAM, during mushroom body formation. This study thus suggests that different formins can cooperate or act independently in distinct tissues, likely integrating various signaling inputs with the regulation of the cytoskeleton. It furthermore highlights the importance and complexity of formin-dependent cytoskeletal regulation in multiple organs and developmental contexts. 2016 264285 true true true false false RESTRICTED 2026-10-21 false true 10018677 Berkes Kata /api/admin/10018677 Admin true 10018677 15 0 15 11 4 15 15 14 15 15 15 11 11 11 4 0 15 11 15 11 0 4 4 Folyóiratcikk Journal Article 24 15 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2017 0 1 1 1 1 2018 0 1 1 1 1 2019 0 0 0 0 0 2020 0 2 2 2 2 2021 0 2 2 2 2 2022 0 1 0 1 0 2023 0 4 2 4 2 2024 0 1 1 1 1 2025 0 1 1 1 1 2026 0 2 1 2 1 D1 false false false false 2017-02-09T10:46:41.000+0000 2016-03-22T11:11:42.000+0000 MTA-SZBK-NAP B Axon növekedés és regeneráció ku... (HRN SZBK / GI) 2 11 1 7 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 7764079 /api/authorship/7764079 1 0.14285715 true false Dollar G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 23995194 true PersonAuthorship 7764080 /api/authorship/7764080 2 0.14285715 false false Author 10024995 /api/author/10024995 Gombos Rita I true 10024995 true Gombos R true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 23995193 true PersonAuthorship 7764081 /api/authorship/7764081 3 0.14285715 false false Barnett AA true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 23995192 true PersonAuthorship 7764082 /api/authorship/7764082 4 0.14285715 false false Sanchez Hernandez D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 23995191 true PersonAuthorship 7764083 /api/authorship/7764083 5 0.14285715 false false Maung SM true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 23995190 true PersonAuthorship 7764084 /api/authorship/7764084 6 0.14285715 false false Author 10010519 /api/author/10010519 Mihály József true 10010519 true Mihaly J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 23995189 true PersonAuthorship 7764085 /api/authorship/7764085 7 0.14285715 false true Jenny A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 23995188 true PublicationIdentifier 1083664 /api/publicationidentifier/1083664 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1534/genetics.115.181438 https://doi.org/10.1534/genetics.115.181438 false 1335302 true PublicationIdentifier 1083666 /api/publicationidentifier/1083666 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true RESTRICTED false NO 47995 https://real.mtak.hu/47995 false 1540767 true PublicationIdentifier 1083663 /api/publicationidentifier/1083663 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000371596400023 https://www.webofscience.com/wos/woscc/full-record/000371596400023 false 1339324 true PublicationIdentifier 15045114 /api/publicationidentifier/15045114 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 84979941656 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84979941656 false 15099242 true PublicationIdentifier 1083665 /api/publicationidentifier/1083665 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 26801180 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26801180&dopt=Abstract false 1335303 true Classification 10545 /api/classification/10545 true true SjrRating 10933981 /api/sjrrating/10933981 21 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1311 /api/classificationexternal/1311 true 1311 true D1 DIRECT true true /api/publication/3040810 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Dollar G </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024995"><a href="/gui2/?type=authors&mode=browse&sel=10024995" target="_blank">Gombos R (<span class="authorship-author-name">Gombos Rita I</span> <span class="authorAux-mtmt"> Genetika</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Barnett AA </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sanchez Hernandez D </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Maung SM </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010519"><a href="/gui2/?type=authors&mode=browse&sel=10010519" target="_blank">Mihaly J (<span class="authorship-author-name">Mihály József</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/<span title="Genetikai Intézet">GI</span>/MTA-SZBK-NAP B Axon növekedés és regeneráció kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jenny A </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3040810" target="_blank">Unique and Overlapping Functions of Formins Frl and DAAM During Ommatidial Rotation and Neuronal Development in Drosophila.</a></div> <div> <span class="journal-title">GENETICS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0016-6731">0016-6731</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1943-2631">1943-2631</a>)</span>: <span class="journal-volume">202</span> <span class="journal-issue">3</span> <span class="page"> pp 1135-1151 </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1534/genetics.115.181438" target="_blank" href="https://doi.org/10.1534/genetics.115.181438"> DOI </a> </span> <span class="id identifier oa_RESTRICTED" title=" Korlátozott "> <a style="color:black" title="47995" target="_blank" href="https://real.mtak.hu/47995"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000371596400023" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000371596400023"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84979941656" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84979941656"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="26801180" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26801180&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Genetics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 15</span> | Független: 11 | Függő: 4 | Nem jelölt: 0 | WoS jelölt: 14 | Scopus jelölt:&nbsp;15 | WoS/Scopus jelölt:&nbsp;15 | DOI jelölt:&nbsp;15 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3040810&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3040810</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> <span class="oldId">Régi azonosító: 3040810</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2020.12.05. 18:13 WoS import (admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Developmental and Molecular Biology, Bronx, NY 10461, United States Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, United States Office for Subsidized Research Units, Hungarian Academy of Sciences (HAS), Budapest, H-1051, Hungary Institute of Genetics, Biological Research Centre,...</pre> </div></div>