https://m2.mtmt.hu/ hun 2026-09-20 23:30 JournalArticle 30386645 VALIDATED true 0 false 2026-09-15T10:55:07.203+0000 2026-04-20T09:00:13.341+0000 2019-01-10T19:14:51.212+0000 true 10010125 Ferdinandy Péter /api/author/10010125 Author true 10010125 2026-04-20T09:00:00.905+0000 2026-04-20T09:00:00.905+0000 2026-04-20T09:00:13.599+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Davidson, Sean M Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury JACC Review Topic of the Week true true /api/journal/2211 REVIEWED true false 2211 false 2211 true 0735-1097 1558-3597 Journal FOREIGN 73 1 89 99 89 11 2019 Many treatments have been identified that confer robust cardioprotection in experimental animal models of acute ischemia and reperfusion injury. However, translation of these cardioprotective therapies into the clinical setting of acute myocardial infarction (AMI) for patient benefit has been disappointing. One important reason might be that AMI is multifactorial, causing cardiomyocyte death via multiple mechanisms, as well as affecting other cell types, including platelets, fibroblasts, endothelial and smooth muscle cells, and immune cells. Many cardioprotective strategies act through common end-effectors and may be suboptimal in patients with comorbidities. In this regard, emerging data suggest that optimal cardioprotection may require the combination of additive or synergistic multitarget therapies. This review will present an overview of the state of cardioprotection today and provide a roadmap for how we might progress towards successful clinical use of cardioprotective therapies following AMI, focusing on the rational combination of judiciously selected, multitarget therapies. This paper emerged as part of the discussions of the European Union (EU)-CARDIOPROTECTION Cooperation in Science and Technology (COST) Action, CA16225. true true 2019 true true true false true false GOLD 2026-09-15 true https://doi.org/10.1016/j.jacc.2018.09.086 647 0 645 561 19 645 640 626 608 644 644 560 560 563 84 0 647 563 645 561 0 5 5 Folyóiratcikk Journal Article 24 643 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 2 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 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true 0 true false true PersonAuthorship 84984984 /api/authorship/84984984 4 0.09090909 false false Bøtker Hans Erik true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 84984985 /api/authorship/84984985 5 0.09090909 false false Heusch Gerd true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 84984986 /api/authorship/84984986 6 0.09090909 false false Ibáñez Borja true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 84984987 /api/authorship/84984987 7 0.09090909 false false Ovize Michel true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 84984988 /api/authorship/84984988 8 0.09090909 false false Schulz Rainer true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 84984989 /api/authorship/84984989 9 0.09090909 false false Yellon Derek M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 84984990 /api/authorship/84984990 10 0.09090909 false false Hausenloy Derek J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 84984991 /api/authorship/84984991 11 0.09090909 false true Garcia-Dorado David true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true OrgAuthorship 84984992 /api/authorship/84984992 12 0.0 false false true false false AuthorshipType 30 /api/authorshiptype/30 -29 true -29 true false true PublicationIdentifier 15119620 /api/publicationidentifier/15119620 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1016/j.jacc.2018.09.086 https://doi.org/10.1016/j.jacc.2018.09.086 false true PublicationIdentifier 15187937 /api/publicationidentifier/15187937 PlainSource 1 /api/publicationsource/1 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Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Davidson Sean M ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy Péter (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Andreadou Ioanna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bøtker Hans Erik </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Heusch Gerd </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ibáñez Borja </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ovize Michel </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schulz Rainer </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yellon Derek M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hausenloy Derek J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Garcia-Dorado David </span> </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">CARDIOPROTECTION COST Action (CA16225)</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30386645" target="_blank">Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury : JACC Review Topic of the Week.</a></div> <div> <span class="journal-title">JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY</span> <span class="journal-issn">(<a target="_blank" 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