https://m2.mtmt.hu/ eng 2026-03-14 23:41 JournalArticle 30386645 VALIDATED true 0 false 2026-03-10T09:59:38.519+0000 2021-04-12T07:14:19.902+0000 2019-01-10T19:14:51.212+0000 true 10010125 Ferdinandy Péter /api/author/10010125 Author true 10010125 2025-07-07T13:20:39.886+0000 2025-07-07T13:20:39.886+0000 2021-04-12T07:14:19.916+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Davidson, Sean M Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury JACC Review Topic of the Week true true /api/journal/2211 REVIEWED true false 2211 false 2211 true 0735-1097 1558-3597 Journal FOREIGN 73 1 89 99 89 11 2019 Many treatments have been identified that confer robust cardioprotection in experimental animal models of acute ischemia and reperfusion injury. However, translation of these cardioprotective therapies into the clinical setting of acute myocardial infarction (AMI) for patient benefit has been disappointing. One important reason might be that AMI is multifactorial, causing cardiomyocyte death via multiple mechanisms, as well as affecting other cell types, including platelets, fibroblasts, endothelial and smooth muscle cells, and immune cells. Many cardioprotective strategies act through common end-effectors and may be suboptimal in patients with comorbidities. In this regard, emerging data suggest that optimal cardioprotection may require the combination of additive or synergistic multitarget therapies. This review will present an overview of the state of cardioprotection today and provide a roadmap for how we might progress towards successful clinical use of cardioprotective therapies following AMI, focusing on the rational combination of judiciously selected, multitarget therapies. 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Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Davidson Sean M ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy Péter (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Andreadou Ioanna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bøtker Hans Erik </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Heusch Gerd </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ibáñez Borja </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ovize Michel </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schulz Rainer </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yellon Derek M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hausenloy Derek J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Garcia-Dorado David </span> </div> <div class="autype autype-29"> Collaborative Organization: <span class="author-affil">CARDIOPROTECTION COST Action (CA16225)</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30386645" target="_blank">Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury : JACC Review Topic of the Week.</a></div> <div> <span class="journal-title">JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0735-1097">0735-1097</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1558-3597">1558-3597</a>)</span>: <span class="journal-volume">73</span> <span class="journal-issue">1</span> <span class="page"> pp 89-99 </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1016/j.jacc.2018.09.086" target="_blank" href="https://doi.org/10.1016/j.jacc.2018.09.086"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000455014900011" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000455014900011"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="8046" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/8046"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85059103889" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85059103889"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="30621955" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30621955&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 613</span> | Independent citation: 530 | Self citation: 83 | Unknown citation: 0 | Number of citations in WoS: 598 | Number of citations in Scopus:&nbsp;538 | WoS/Scopus assigned:&nbsp;610 | Number of citations with DOI:&nbsp;606 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30386645&sort=publishedYear,desc&sort=title"> Number of cited publications: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 30386645</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Study Group ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed (pubmed_result (6).xml, 2019-01-10)</span> </div> <div class="lastModified">Last Modified: 2021.04.12. 09:14 Márta Molnár-Taga (SE 4-es admin) </div> </div></div>