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Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain
Molecular Recognition & Host-Pathogen Interactions Unit, CIC bioGUNE, Bizkaia Technology Park, Building 801A, Derio, 48170, Spain
Ikerbasque, Basque Foundation for Science, Maria Diaz de Haro 13, Bilbao, 48009, Spain
Department of Organic Chemistry II, Faculty of Science & Technology, University of the Basque Country, Leioa, 48940, Spain
Combinatorial Chemistry Unit, Barcelona Science Park, Baldiri Reixac 10, Barcelona, 08028, Spain
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona Science Park, Baldiri Reixac 10, Barcelona, 08028, Spain
Cited By :5
Export Date: 6 March 2024
CODEN: CEUJE
Correspondence Address: Sussman, F.; Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Spain; email: fredy.sussman@usc.es
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Environmental Effects Determine the Structure of Potential beta-Amino Acid Based Foldamers
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This work shows that hybrid peptides formed by alternating trans-2-aminocyclopentanecarboxylic acid (trans-ACPC) and trans-2-aminocyclohexanecarboxylic acid (trans-ACHC) do not fold in the solvents typically used in the study of their homo-oligomers. Only when the peptides are assayed in SDS micelles are the predicted helical structures obtained. This indicates that the environment could play an equally important role (as the backbone stereochemistry) in determining their fold, possibly by providing a sequestered environment.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Sussman, Fredy </span> <span class="author-type"> </span> ; <span class="author-name" > Sanchez-Pedregal, Victor M. </span> <span class="author-type"> </span> ; <span class="author-name" > Estevez, Juan C. </span> <span class="author-type"> </span> ; <span class="author-name" > Balo, Rosalino </span> <span class="author-type"> </span> ; <span class="author-name" > Jimenez-Barbero, Jesus </span> <span class="author-type"> </span> ; <span class="author-name" > Arda, Ana </span> <span class="author-type"> </span> ; <span class="author-name" > Gimeno, Ana </span> <span class="author-type"> </span> ; <span class="author-name" > Royo, Miriam </span> <span class="author-type"> </span> ; <span class="author-name" > Carmen Villaverde, M. </span> <span class="author-type"> </span> ; <span class="author-name" > Estevez, Ramon J. </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;30378685" mtid="30378685" target="_blank">Environmental Effects Determine the Structure of Potential beta-Amino Acid Based Foldamers</a></div> <div class="pub-info"> <span class="journal-title">CHEMISTRY-A EUROPEAN JOURNAL</span> <span class="journal-volume">24</span> : <span class="journal-issue">42</span> <span class="page"> pp. 10625-10629. , 5 p. </span> <span class="year">(2018)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1002/chem.201801953" target="_blank" href="https://doi.org/10.1002/chem.201801953"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000439925300010" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000439925300010"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85050497081" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85050497081"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="29809294" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29809294&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:30378685 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Nyilvános </span></span> <span class="pub-core"> Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="autype autype0"> <span class="author-name" >Sussman Fredy
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<span class="author-name" >Sanchez-Pedregal Victor M.
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<span class="author-name" >Estevez Juan C.
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<span class="author-name" >Royo Miriam
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<span class="author-name" >Carmen Villaverde M.
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<span class="author-name" >Estevez Ramon J.
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;30378685" target="_blank">Environmental Effects Determine the Structure of Potential beta-Amino Acid Based Foldamers</a></div> <div> <span class="journal-title">CHEMISTRY-A EUROPEAN JOURNAL</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0947-6539">0947-6539</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1521-3765">1521-3765</a>)</span>:
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Idézett közlemények száma: 7
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<div class="mtid"><span class="long-pub-mtid">Közlemény: 30378685</span>
| <span class="status-data status-APPROVED"> Nyilvános
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<div class="lastModified">Utolsó módosítás: 2024.02.27. 14:18 Pécsi Éva (MTMT Közp 3, admin)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain
Molecular Recognition & Host-Pathogen Interactions Unit, CIC bioGUNE, Bizkaia Technology Park, Building 801A, Derio, 48170, Spain
Ikerbasque, Basque Fo...</pre>
</div></div>