Environmental Effects Determine the Structure of Potential beta-Amino Acid Based Foldamers

Sussman, Fredy; Sanchez-Pedregal, Victor M.; Estevez, Juan C.; Balo, Rosalino; Jimenez-Barbero, Jesus; Arda, Ana; Gimeno, Ana; Royo, Miriam; Carmen Villaverde, M.; Estevez, Ramon J.

Angol nyelvű Tudományos Szakcikk (Folyóiratcikk)
Megjelent: CHEMISTRY-A EUROPEAN JOURNAL 0947-6539 1521-3765 24 (42) pp. 10625-10629 2018
  • SJR Scopus - Chemistry (miscellaneous): D1
Azonosítók
Szakterületek:
    This work shows that hybrid peptides formed by alternating trans-2-aminocyclopentanecarboxylic acid (trans-ACPC) and trans-2-aminocyclohexanecarboxylic acid (trans-ACHC) do not fold in the solvents typically used in the study of their homo-oligomers. Only when the peptides are assayed in SDS micelles are the predicted helical structures obtained. This indicates that the environment could play an equally important role (as the backbone stereochemistry) in determining their fold, possibly by providing a sequestered environment.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2021-09-18 11:49