Succinate is an important metabolite at the cross-road of several metabolic pathways,
also involved in the formation and elimination of reactive oxygen species. However,
it is becoming increasingly apparent that its realm extends to epigenetics, tumorigenesis,
signal transduction, endo- and paracrine modulation and inflammation. Here we review
the pathways encompassing succinate as a metabolite or a signal and how these may
interact in normal and pathological conditions.1.
