Data on the basal (constitutive or spontaneous) activities of receptors, as well as
their neurochemical and electrophysiological correlates, are presented. Inverse receptor
agonists are a group of pharmacological drugs that can suppress constitutive activities.
We describe the neurochemical mechanisms of the pharmacological activities of benzodiazepine
binding site inverse agonists. These compounds inhibit chloride currents caused by
gamma-aminobutyric acid at low non-physiological concentrations. This activity is
the basis of the sobering action during the action of ethanol and the ability to suppress
the addictive potential of psychoactive substances. In addition, the benzodiazepine
binding site inverse agonists are able to activate memory formation processes and
improve learning. The possible uses of drugs from this group in modern medicine are
discussed. They may be used to treat a number of diseases in the fields of narcology,
therapy, neurology, and psychiatry.