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      <comment>College of Biological Sciences, China Agricultural University, Beijing, China 
 National Institute of Biological Sciences, Beijing, China 
 Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States 
 Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States 
 Department of Biological Sciences, Purdue University, West Lafayette, IN, United States 
 Department of Genetics and the Human Genetics Institute of New Jersey, Rutgers, the State University of New Jersey, Piscataway, NJ, United States 
 Department of Traditional Chinese Medicine, Xinhua Hospital Affiliated to Shanghai Jiatong University School of Medicine, Shanghai, China 
 Center for Genomic Medicine, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States 
 Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States 
 Yale Child Study Center and Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States 
 Department of Child and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, Netherlands 
 Department of Neuroscience, Child and Adolescent Psychiatry Uppsala University, Uppsala, Sweden 
 Centre for Research and Development, Region Gävleborg, Gävle, Sweden 
 Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden 
 Department of Neurology, University of California, Los Angeles, Los Angeles, CA, United States 
 Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, United States 
 Department of Psychiatry, Genetics Institute, University of Florida, Gainesville, FL, United States 
 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States 
 Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, United States 
 Export Date: 7 December 2018 
 Correspondence Address: Paschou, P.; Department of Biological Sciences, Purdue UniversityUnited States; email: ppaschou@purdue.edu 
 Funding details: Fundación Mutua Madrileña 
 Funding details: Peking University, PKU 
 Funding details: Department of Health, DH, Copenhagen 
 Funding details: University College London, UCL 
 Funding details: Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía, CVI-02526 
 Funding details: Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía, CTS-7685 
 Funding details: 1HG006504-05 
 Funding details: Deutsche Forschungsgemeinschaft, DFG 
 Funding details: Pharmaceutical Research and Manufacturers of America Foundation 
 Funding details: Instituto de Salud Carlos III, ISCIII, PI13/01461 
 Funding details: Instituto de Salud Carlos III, ISCIII, PI10/01674 
 Funding details: Fundación Alicia Koplowitz 
 Funding details: Deutsche Forschungsgemeinschaft, DFG, MU 1692/3-1 
 Funding details: Deutsche Forschungsgemeinschaft, DFG, MU 1692/4-1 
 Funding details: Deutsche Forschungsgemeinschaft, DFG, SFB 936 
 Funding details: Stanley Center for Psychiatric Research, Broad Institute 
 Funding details: National Human Genome Research Institute, NHGRI 
 Funding details: Field Neurosciences Institute, FNI 
 Funding details: Great Ormond Street Hospital Charity, GOSH 
 Funding details: Jacques und Gloria Gossweiler-Stiftung, JGGF 
 Funding details: Sociedad Andaluza de Neurología, SAN 
 Funding details: Beatrice and Samuel A. Seaver Foundation 
 Funding details: National Heart, Lung, and Blood Institute, NHLBI, U24 HG008956 
 Funding details: Icahn School of Medicine at Mount Sinai, ISMMS 
 Funding details: Consejería de Salud, Junta de Andalucía, PI-0741/2010 
 Funding details: Consejería de Salud, Junta de Andalucía, PI-0437-2012 
 Funding details: Consejería de Salud, Junta de Andalucía, PI-0471-2013 
 Funding details: U24MH068457 
 Funding details: Great Ormond Street Hospital Charity, GOSH 
 Funding details: Hannover Rück 
 Funding details: National Institutes of Health, NIH 
 Funding details: National Institute for Health Research, NIHR 
 Funding details: 2015-02424 
 Funding details: National Institute of Mental Health, NIMH, R01MH092516 
 Funding details: National Institute of Mental Health, NIMH, R01MH092289 
 Funding details: National Institute of Mental Health, NIMH, R01MH092290 
 Funding details: National Institute of Mental Health, NIMH, R01MH092520 
 Funding details: National Institute of Mental Health, NIMH, K08MH099424 
 Funding details: National Institute of Mental Health, NIMH, R01MH092292 
 Funding details: National Institute of Mental Health, NIMH, R01MH092293 
 Funding details: National Institute of Mental Health, NIMH, R01MH092291 
 Funding details: National Institute of Mental Health, NIMH, R01MH092513 
 Funding details: Tourette Association of America, TSA 
 Funding details: Daiichi Sankyo Company 
 Funding text 1: We wish to thank the families who have participated in and contributed to this study. We also thank the NIMH Repository and Genomics Resource ( U24MH068457 to J.A.T.) at RUCDR Infinite Biologics for transforming cell lines and providing DNA samples, Liping Wei at Peking University for her support in this project, and Sarah Pyle for graphic design. This study was supported by grants from the National Institute of Mental Health ( R01MH092290 to Lawrence W. Brown, R01MH092291 to Samuel Kuperman, R01MH092292 to Barbara J. Coffey, R01MH092293 to G.A.H. and J.A.T., R01MH092513 to Samuel H. Zinner, R01MH092516 to D.E.G., R01MH092520 to Donald L. Gilbert, R01MH092289 to M.W.S., and K08MH099424 to T.V.F.), from the Human Genetics Institute of New Jersey (to G.A.H. and J.A.T.), and the New Jersey Center for Tourette Syndrome and Associated Disorders (to G.A.H. and J.A.T.). We are also grateful to the NJCTS for facilitating the inception and organization of the TIC Genetics study. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. This study was also supported by the Weill Institute for Neurosciences (Startup Funding to A.J.W.) and the Overlook International Foundation (to M.W.S. and A.J.W.). The Yale Center for Mendelian Genomics ( NIH M#UM1HG006504-05 ) is funded by the National Human Genome Research Institute and the National Heart, Lung, and Blood Institute . The GSP Coordinating Center ( U24 HG008956 ) contributed to cross-program scientific initiatives and provided logistical and general study coordination. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. This work was additionally supported by grants from Spain (to Pablo Mir): the Instituto de Salud Carlos III ( PI10/01674 and PI13/01461 ); the Consejería de Economía, Innovación, Ciencia y Empresa de la Junta de Andalucía ( CVI-02526 and CTS-7685 ); the Consejería de Salud y Bienestar Social de la Junta de Andalucía ( PI-0741/2010 , PI-0437-2012 , and PI-0471-2013 ); the Sociedad Andaluza de Neurología ; the Fundación Alicia Koplowitz ; the Fundación Mutua Madrileña ; and the Jaques and Gloria Gossweiler Foundation , (to Astrid Morer): Alicia Koplowitz Foundation ; grants from Germany (to Astrid Morer): Deutsche Forschungsgemeinschaft (DFG) ( MU 1692/3-1 and MU 1692/4-1 and project C5 of the SFB 936 ); and grants from Sweden: the Swedish Research Council 2015-02424 (to N.D.). This research was also supported in part by an Informatics Starter Grant from the PhRMA Foundation (to Yana Bromberg), the Mindich Child Health and Developmental Institute at the Icahn School of Medicine at Mount Sinai (to D.E.G.), the Seaver Foundation (to D.E.G.), and the Stanley Center for Psychiatric Research (to D.E.G.). All research at Great Ormond Street Hospital NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health is made possible by the NIHR Great Ormond Street Hospital Biomedical Research Centre . The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. We are grateful to all of the families at the participating Simons Simplex Collection (SSC) sites, as well as the principal investigators (A. Beaudet, R. Bernier, J. Constantino, E. Cook, E. Fombonne, D. Geschwind, R. Goin-Kochel, E. Hanson, D. Grice, A. Klin, D. Ledbetter, C. Lord, C. Martin, D. Martin, R. Maxim, J. Miles, O. Ousley, K. Pelphrey, B. Peterson, J. Piggot, C. Saulnier, M. State, W. Stone, J. Sutcliffe, C. Walsh, Z. Warren, and E. Wijsman). We also appreciate obtaining access to whole-exome sequencing, microarray genotyping, and phenotype data on SFARI Base. Approved researchers can obtain the SSC population dataset described in this study by applying at https://base.sfari.org . Finally, we thank all of the individuals involved in recruitment and assessment of the subjects reported in this study: Denmark: Nikoline Frost and Heidi B. Biernat (Copenhagen); Germany: Yvonne Friedrich (Dresden), Daniela Ihlenburg-Schwarz (Hannover), and Jenny Schmalfeld (Lübeck); Spain: Fátima Carrillo, Marta Correa, Pilar Gómez-Garre, and Laura Vargas (Sevilla); the Netherlands: Vivian op de Beek (Amsterdam); Jolanda Blom, Rudi Bruggemans, and MariAnne Overdijk (Barendrecht); and Marieke Messchendorp, Thaïra Openneer, and Anne Marie Stolte (Groningen); UK: Anup Kharod (London GOSH); USA: Sarah Jacobson (Cincinnati), Angie Cookman (Iowa City), Laura Ibanez-Gomez and Zoey Shaw (Mount Sinai/NKI), Shannon Granillo and J.D. Sandhu (Seattle Children’s), and Yanran Wang (Rutgers); and to all who may not have been mentioned. 
 Funding text 2: Conceptualization, S.W., T.V.F., G.A.H., J.A.T., P.P., A.J.W., and M.W.S.; Methodology, S.W., R.A.K., T.V.F., G.A.H., J.A.T., P.P., A.J.W., and M.W.S.; Software, S.W., J.D.M., and A.J.W.; Validation, S.W., N.S., M.T.M., J.A., C.D., D.Y., A.Y.H., G.C., J.M.S., T.V.F., J.X., and A.J.W.; Formal Analysis, S.W., J.D.M., S.D., X.Z., and A.J.W.; Investigation, S.W., J.D.M., J.M.S., T.V.F., J.X., G.A.H., J.A.T., P.P., A.J.W., and M.W.S.; Resources, R.A.K., A.D., N.K., N.D., B.M.N., G.C., C.A.M., J.M.S., TIC Genetics, TSGENESEE, TAAICG, T.V.F., J.D.B., S.D.R., D.E.G., J.X., G.A.H., J.A.T., P.P., A.J.W., and M.W.S.; Data Curation, S.W., J.D.M., D.Y., A.D., N.K., N.D., C.A.M., J.M.S., T.V.F., J.D.B., S.D.R., D.E.G., J.X., G.A.H., J.A.T., P.P., and A.J.W.; Writing – Original Draft, S.W., J.D.M., A.J.W., and M.W.S.; Writing – Review &amp; Editing, S.W., J.D.M., Y.K., N.S., M.T.M., J.A., C.N., S.D., C.D., X.Z., Z.Y., S.S.P., D.Y., R.A.K., A.D., N.K., N.D., A.Y.H., B.M.N., G.C., C.A.M., J.M.S., TIC Genetics, TSGENESEE, TAAICG, T.V.F., J.D.B., S.D.R., D.E.G., J.X., G.A.H., J.A.T., P.P., A.J.W., and M.W.S.; Visualization, S.W. and A.J.W.; Supervision, R.A.K., T.V.F., J.D.B., S.D.R., D.E.G., J.X., G.A.H., J.A.T., P.P., A.J.W., and M.W.S.; Project Administration, B.M.N., G.C., C.A.M., J.M.S., G.A.H., J.A.T., P.P., A.J.W., and M.W.S.; Funding Acquisition, N.K., N.D., B.M.N., G.C., C.A.M., J.M.S., T.V.F., J.X., G.A.H., J.A.T., P.P., A.J.W., and M.W.S. 
 Funding text 3: Donald L. Gilbert has received salary/travel/honoraria from the Tourette Association of America, the Child Neurology Society, U.S. National Vaccine Injury Compensation Program, Ecopipam Pharmaceuticals, EryDel Pharmaceuticals, Elsevier, and Wolters Kluwer. A.J.W. is a paid consultant for Daiichi Sankyo. M.W.S. is a consultant to BlackThorn and ArRett Pharmaceuticals.</comment>
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      <label>Wang S. et al. De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis. (2018) CELL REPORTS 2639-1856 2211-1247 24 13 3441-3454.e12</label><template>&lt;div class=&quot;JournalArticle Publication short-list&quot;&gt; &lt;div class=&quot;authors&quot;&gt; &lt;span class=&quot;author-name&quot; &gt; Wang, S. &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Mandell, J.D. &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Kumar, Y. &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Sun, N. &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Morris, M.T. &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Arbelaez, J. &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Nasello, C. &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Dong, S. &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Duhn, C. &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Zhao, X. &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; et al. &lt;/div &gt;&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;30340629&quot; mtid=&quot;30340629&quot; target=&quot;_blank&quot;&gt;De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis&lt;/a&gt;&lt;/div&gt; &lt;div class=&quot;pub-info&quot;&gt; &lt;span class=&quot;journal-title&quot;&gt;CELL REPORTS&lt;/span&gt; &lt;span class=&quot;journal-volume&quot;&gt;24&lt;/span&gt; : &lt;span class=&quot;journal-issue&quot;&gt;13&lt;/span&gt; &lt;span class=&quot;page&quot;&gt; pp. 3441-3454.e12. &lt;/span&gt; &lt;span class=&quot;year&quot;&gt;(2018)&lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;pub-end&quot;&gt;&lt;div class=&quot;identifier-list&quot;&gt; &lt;span class=&quot;identifiers&quot;&gt; &lt;span class=&quot;id identifier oa_GOLD&quot; title=&quot; Gold &quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;10.1016/j.celrep.2018.08.082&quot; target=&quot;_blank&quot; href=&quot;https://doi.org/10.1016/j.celrep.2018.08.082&quot;&gt; DOI &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;000445524700009&quot; target=&quot;_blank&quot; href=&quot;https://www.webofscience.com/wos/woscc/full-record/000445524700009&quot;&gt; WoS &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;85053405532&quot; target=&quot;_blank&quot; href=&quot;http://www.scopus.com/record/display.url?origin=inward&amp;eid=2-s2.0-85053405532&quot;&gt; Scopus &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;30257206&quot; target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=30257206&amp;dopt=Abstract&quot;&gt; PubMed &lt;/a&gt; &lt;/span&gt; &lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;short-pub-prop-list&quot;&gt; &lt;span class=&quot;short-pub-mtid&quot;&gt; Közlemény:30340629 &lt;/span&gt; &lt;span class=&quot;status-holder&quot;&gt;&lt;span class=&quot;status-data status-APPROVED&quot;&gt; Nyilvános &lt;/span&gt;&lt;/span&gt; &lt;span class=&quot;pub-core&quot;&gt;Forrás Idéző &lt;/span&gt; &lt;span class=&quot;pub-type&quot;&gt;Folyóiratcikk (Sokszerzős vagy csoportos szerzőségű szakcikk ) &lt;/span&gt; &lt;!-- &amp;&amp; !record.category.scientific --&gt; &lt;span class=&quot;pub-category&quot;&gt;Tudományos&lt;/span&gt; &lt;div class=&quot;publication-citation&quot; style=&quot;margin-left: 0.5cm;&quot;&gt; &lt;span title=&quot;Nyilvános idézőközlemények összesen, említések nélkül&quot; class=&quot;citingPub-count&quot;&gt;Nyilvános idéző összesen: 92&lt;/span&gt; | Független: 57 | Függő: 35 | Nem jelölt: 0 | WoS jelölt: 78 | Scopus jelölt:&amp;nbsp;87 | WoS/Scopus jelölt:&amp;nbsp;92 | DOI jelölt:&amp;nbsp;91 &lt;/div&gt; &lt;/div&gt; &lt;/div&gt; &lt;/div&gt;</template><template2>&lt;div class=&quot;JournalArticle Publication long-list&quot;&gt;
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																																																																																																									 et al. (35)
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		&lt;div class=&quot;autype autype-11&quot;&gt;			Kollaborációs közreműködő:
				&lt;span class=&quot;author-name&quot; &gt;Mohamed Abdulkadir
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            &lt;span class=&quot;authorAux-mtmt&quot;&gt; gyermek- és ifjúságpszichiátria&lt;/span&gt;)
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																																																																																																																																																 et al. (120)
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&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;30340629&quot; target=&quot;_blank&quot;&gt;De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis&lt;/a&gt;&lt;/div&gt;    &lt;div&gt;		&lt;span class=&quot;journal-title&quot;&gt;CELL REPORTS&lt;/span&gt;

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Forrás	 Idéző
	
	
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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2024.08.26. 16:50 Nagy Péter (gyermek- és ifjúságpszichiátria)
&lt;/div&gt;




	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: College of Biological Sciences, China Agricultural University, Beijing, China 
 National Institute of Biological Sciences, Beijing, China 
 Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States 
 Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California, San Fra...&lt;/pre&gt;

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