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Alterations of mineralized matrix by lead exposure in osteoblast (MC3T3-E1) culture
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The present study investigated the effect of lead (Pb) on bone ultrastructure and chemistry using an in vitro bone model. MC3T3-E1 preosteoblasts were differentiated and treated with lead acetate at 0.4, 2, 10, and 50 mu M. No abnormalities in either cell growth or bone nodule formation were observed with the treated dose of lead acetate. However, Pb treatments could significantly increase Pb accumulation in differentiated osteoblast cultures and upregulate expression of Divalent metal transporter 1 (Dmt1) in a dose dependent manner. Pb treatments also altered the expression of osteogenic genes, including secreted phosphoprotein 1, osteocalcin, type I collagen, and osteoprotegerin. Moreover, in mineralized osteoblast cultures, Pb was found to be mainly deposited as Pb salts and oxides, respectively. Ultrastructure analysis revealed Pb localizing with calcium and phosphorus in the mineralized matrix. In mineralizing osteoblast cells, Pb was found in the intracellular calcified vesicles which is one of the bone mineralization mechanisms. Pb was also present in mineral deposits with various shapes and sizes, such as small and large globular or needle-like mineral deposits representing early to mature stages of mineral deposits. Furthermore, Pb was found more in the globular deposits than the needle shaped mineral crystals. Taken together, our observations revealed how Pb incorporates into bone tissue, and showed a close association with bone apatite.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Paisrisarn, Piyawan </span> <span class="author-type"> </span> ; <span class="author-name" > Tepaamorndech, Surapun </span> <span class="author-type"> </span> ; <span class="author-name" > Khongkow, Mattaka </span> <span class="author-type"> </span> ; <span class="author-name" > Khemthong, Pongtanawat </span> <span class="author-type"> </span> ; <span class="author-name" > Kasamechonchung, Panita </span> <span class="author-type"> </span> ; <span class="author-name" > Klysubun, Wantana </span> <span class="author-type"> </span> ; <span class="author-name" > Wutikhun, Tuksadon </span> <span class="author-type"> </span> ; <span class="author-name" > Huang, Liping </span> <span class="author-type"> </span> ; <span class="author-name" > Chantarasakha, Kanittha </span> <span class="author-type"> </span> ; <span class="author-name" > Boonrungsiman, Suwimon </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;30336902" mtid="30336902" target="_blank">Alterations of mineralized matrix by lead exposure in osteoblast (MC3T3-E1) culture</a></div> <div class="pub-info"> <span class="journal-title">TOXICOLOGY LETTERS</span> <span class="journal-volume">299</span> <span class="page"> pp. 172-181. , 10 p. </span> <span class="year">(2018)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.toxlet.2018.10.008" target="_blank" href="https://doi.org/10.1016%2Fj.toxlet.2018.10.008"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000448578200020" target="_blank" href="http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=000448578200020&DestApp=WOS"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="85054980583" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85054980583"> Scopus </a> </span> </span> </div> <span class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:30336902 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core"> Idéző</span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> </span> </div> </div><div class="JournalArticle Publication long-list">
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<div class="autype autype0"> <span class="author-name" >Paisrisarn Piyawan
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<span class="author-name" >Tepaamorndech Surapun
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<span class="author-name" >Khongkow Mattaka
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<span class="author-name" >Huang Liping
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;
<span class="author-name" >Boonrungsiman Suwimon
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;30336902" target="_blank">Alterations of mineralized matrix by lead exposure in osteoblast (MC3T3-E1) culture</a></div> <div> <span class="journal-title">TOXICOLOGY LETTERS</span>
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Idézett közlemények száma: 1
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<div class="mtid"><span class="long-pub-mtid">Közlemény: 30336902</span>
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<div class="lastModified">Utolsó módosítás: 2020.02.18. 12:10 Sápi András (Kémia)
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