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The authors would like to thank Alice Tillema for help in optimizing the search strategy, Matthijs Feenstra for proofreading an earlier draft of this manuscript, and Judith van Luijk for proofreading the protocol and checking a small sample of concentration calculations for accuracy. The authors have no conflict of interest to declare.\nCited By :4 \n Export Date: 28 May 2020 \n CODEN: JONRA \n Correspondence Address: Leenaars, C.H.C.; SYRCLE, Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical CenterNetherlands; email: cathalijn.leenaars@radboudumc.nl \n Chemicals/CAS: adenosine, 58-61-7; adenosine phosphate, 61-19-8, 8063-98-7; Adenosine; Adenosine Monophosphate \n Funding details: Deutsche Forschungsgemeinschaft, DFG, FOR2591, BL 953/11-1 \n Funding details: ZonMw, 40-42600-98-301 \n Funding text 1: Funding for this project was provided by ZonMw (40-42600-98-301); R2N, Federal State of Lower Saxony and the DFG (FOR2591, BL 953/11-1). The authors would like to thank Alice Tillema for help in optimizing the search strategy, Matthijs Feenstra for proofreading an earlier draft of this manuscript, and Judith van Luijk for proofreading the protocol and checking a small sample of concentration calculations for accuracy. 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It can be used to measure various small molecules including the neuroregulator adenosine. Baseline levels of the compounds measured with microdialysis vary over studies. We systematically reviewed the literature to investigate the full range of reported baseline concentrations of adenosine and adenosine monophosphate in microdialysates. We performed a meta-regression analysis to study the influence of flow rate, probe membrane surface area, species, brain area and anaesthesia versus freely behaving, on the adenosine concentration. Baseline adenosine concentrations in microdialysates ranged from 0.8 to 2100nM. There was limited evidence on baseline adenosine monophosphate concentrations in microdialysates. Across studies, we found effects of flow rate and anaesthesia versus freely behaving on dialysate adenosine concentrations (p0.001), but not of probe membrane surface, species, or brain area (p0.14). With increasing flow rate, adenosine concentrations decreased. With anaesthesia, adenosine concentrations increased. The effect of other predictor variables on baseline adenosine concentrations, for example, post-surgical recovery time, could not be analysed because of a lack of reported data. This study shows that meta-regression can be used as an alternative to new animal experiments to answer research questions in the field of neurochemistry. However, current levels of reporting of primary studies are insufficient to reach the full potential of this approach; 63 out of 133 studies could not be included in the analysis because of insufficient reporting, and several potentially relevant factors had to be excluded from the analyses. 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