https://m2.mtmt.hu/
eng
2024-03-29 01:25
JournalArticle
30331520
VALIDATED
true
Department of Organic Chemistry, University of Szeged, Dóm tér 8, Szeged, H-6720, Hungary
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, H-1521, Hungary
1st Department of Medicine, University of Szeged, Korányi fasor 8-10, Szeged, H-6720, Hungary
Membrane protein research group, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, Budapest, H-1117, Hungary
Department of Medicinal Chemistry, University of Szeged, Dóm tér 8, Szeged, H-6720, Hungary
Cited By :9
Export Date: 26 August 2021
CODEN: BJOCB
Correspondence Address: Mernyák, E.; Department of Organic Chemistry, Dóm tér 8, Hungary; email: bobe@chem.u-szeged.hu
0
false
2024-02-19T18:31:02.995+0000
2021-01-13T13:21:30.586+0000
2018-11-28T10:04:04.767+0000
true
1272454
Keglevich
György
/api/author/1272454
Author
true
1272454
2024-01-11T12:58:34.068+0000
2020-04-27T08:45:53.075+0000
true
10026258
Nemesvári
Zoltánné
/api/admin/10026258
Admin
true
10026258
Admin
10063514
/api/admin/10063514
Mikola
Katalin
true
10063514
true
2023-01-17T08:55:45.530+0000
true
false
true
24
24
/api/publicationtype/24
PublicationType
1
true
24
JournalArticle
true
10000059
Article
true
24
24
/api/publicationtype/24
PublicationType
1
true
24
JournalArticle
/api/subtype/10000059
Szakcikk
SubType
101
true
10000059
true
1
/api/category/1
Category
true
1
Jójárt, R.
Pd-Catalyzed microwave-assisted synthesis of phosphonated 13α-estrones as potential OATP2B1, 17β-HSD1 and/or STS inhibitors
true
true
/api/journal/10005426
REVIEWED
true
false
10005426
false
10005426
true
1860-5397
1860-5397
Journal
FOREIGN
14
2838
2845
2838
8
2018
Novel 2- or 4-phosphonated 13 alpha-estrone derivatives were synthesized via the Hirao reaction. Bromo regioisomers (2- or 4-) of 13 alpha-estrone and its 3-benzyl or 3-methyl ether were reacted with diethyl phosphite or diphenylphosphine oxide using Pd(PPh3)(4) as catalyst under microwave irradiation. The influence of the new compounds on the transport function of the organic anion transporting polypeptide OATP2B1 was investigated by measuring Cascade Blue uptake. Derivatives bearing a 3-benzyl ether function displayed substantial submicromolar OATP2B1 inhibitory activity. The inhibitory effects of the compounds on human placental steroid sulfatase (STS) and 17 beta-hydroxysteroid dehydrogenase type 1 isozyme (17 beta-HSD1) were investigated by in vitro radiosub-strate incubation methods. None of the test compounds inhibited the STS markedly. The structure-activity relationship evaluation revealed that 2-substituted 3-hydroxy derivatives are able to inhibit the 17 beta-HSD1 enzyme with submicromolar IC50 values. Dual OATP2B1 and 17 beta-HSD1 inhibitors have been identified.
true
true
2018
true
true
true
false
true
false
GOLD
2024-02-19
true
https://doi.org/10.3762/bjoc.14.262
18
0
16
5
7
16
16
16
15
16
16
5
5
7
11
0
18
7
16
5
0
9
9
Folyóiratcikk
Journal Article
24
15
Könyvrészlet
Chapter in Book
25
1
Könyv
Book
23
0
Egyéb konferenciaközlemény
Conference paper
31
0
Egyéb konferenciakötet
Conference proceedings
32
0
Oltalmi formák
Protection forms
26
0
Disszertáció
Thesis
28
2
Egyéb
Miscellaneous
29
0
Alkotás
Achievement
22
0
Kutatási adat
Research data
33
0
Folyóiratcikk
Journal Article
24
0
0
0
Könyvrészlet
Chapter in Book
25
0
0
0
Könyv
Book
23
0
0
0
Egyéb konferenciaközlemény
Conference paper
31
0
0
0
Egyéb konferenciakötet
Conference proceedings
32
0
0
0
Oltalmi formák
Protection forms
26
0
0
0
Disszertáció
Thesis
28
0
0
0
Egyéb
Miscellaneous
29
0
0
0
Alkotás
Achievement
22
0
0
0
Kutatási adat
Research data
33
0
0
0
2019
0
3
2
3
2
2020
0
4
2
4
2
2021
0
8
1
8
1
2022
0
1
1
1
1
2023
0
2
1
2
1
Q2
false
10012035,10001367
false
false
false
2019-01-14T10:39:39.983+0000
2018-11-28T10:05:02.412+0000
I. sz. Belgyógyászati Klinika (SZTE / SZAOK / BK); Membránfehérje Bioinformatika Kutatócsoport (Le... (HRN TTK / MÉI); Orvosi Vegytani Intézet (SZTE / SZAOK); Szerves Kémia és Technológia Tanszék (BME / VBK); Szerves Kémiai Tanszék (SZTE / TTIK / KI)
7
40
5
8
0
true
10063514
Language
10002
/api/language/10002
Angol
English
true
2
true
PersonAuthorship
84447436
/api/authorship/84447436
1
0.125
true
false
Author
10060683
/api/author/10060683
Jójárt
Rebeka
true
10060683
true
Jójárt
R.
true
false
false
AuthorshipType
1
/api/authorshiptype/1
0
true
0
true
false
true
PersonAuthorship
84447437
/api/authorship/84447437
2
0.125
false
false
Pécsy
S.
true
false
false
AuthorshipType
1
/api/authorshiptype/1
0
true
0
true
false
true
PersonAuthorship
84447438
/api/authorship/84447438
3
0.125
false
false
Author
1272454
/api/author/1272454
Keglevich
György
true
1272454
true
Keglevich
G.
true
false
false
AuthorshipType
1
/api/authorshiptype/1
0
true
0
true
false
true
PersonAuthorship
84447439
/api/authorship/84447439
4
0.125
false
false
Author
10001367
/api/author/10001367
Szécsi
Mihály
true
10001367
true
Szécsi
M.
true
false
false
AuthorshipType
1
/api/authorshiptype/1
0
true
0
true
false
true
PersonAuthorship
84447440
/api/authorship/84447440
5
0.125
false
false
Author
10068092
/api/author/10068092
Laczkó-Rigó
Réka
true
true
Rigó
R.
true
false
false
AuthorshipType
1
/api/authorshiptype/1
0
true
0
true
false
true
PersonAuthorship
84447441
/api/authorship/84447441
6
0.125
false
false
Author
10011564
/api/author/10011564
Laczka
Csilla
true
10011564
true
Ozvegy-Laczka
C.
true
false
false
AuthorshipType
1
/api/authorshiptype/1
0
true
0
true
false
true
PersonAuthorship
84447442
/api/authorship/84447442
7
0.125
false
false
Author
10063503
/api/author/10063503
Kecskeméti
Gábor
true
10063503
true
Kecskeméti
G.
true
false
false
AuthorshipType
1
/api/authorshiptype/1
0
true
0
true
false
true
PersonAuthorship
84447443
/api/authorship/84447443
8
0.125
false
true
true
Author
10012035
/api/author/10012035
Mernyák
Erzsébet
true
10012035
true
Mernyák
E.
true
false
false
AuthorshipType
1
/api/authorshiptype/1
0
true
0
true
false
true
PublicationIdentifier
14630028
/api/publicationidentifier/14630028
GOLD
true
IDENTICAL
10.3762/bjoc.14.262
https://doi.org/10.3762/bjoc.14.262
false
true
PublicationIdentifier
14723503
/api/publicationidentifier/14723503
GREEN
true
88545
http://real.mtak.hu/88545
false
true
PublicationIdentifier
15142122
/api/publicationidentifier/15142122
IDENTICAL
000451065700001
https://www.webofscience.com/wos/woscc/full-record/000451065700001
false
true
PublicationIdentifier
14630027
/api/publicationidentifier/14630027
IDENTICAL
85056862646
http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85056862646
false
true
PublicationIdentifier
15142121
/api/publicationidentifier/15142121
IDENTICAL
30498534
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30498534&dopt=Abstract
false
true
PublicationIdentifier
15121195
/api/publicationidentifier/15121195
GREEN
true
IDENTICAL
14374
http://publicatio.bibl.u-szeged.hu/14374
false
true
Classification
10293
/api/classification/10293
true
true
Keyword
558
/api/keyword/558
true
558
true
Keyword
3176
/api/keyword/3176
true
3176
true
Keyword
1112232
/api/keyword/1112232
true
1112232
true
Keyword
1304652
/api/keyword/1304652
true
1304652
true
Keyword
1612267
/api/keyword/1612267
true
true
Keyword
1852838
/api/keyword/1852838
true
true
Keyword
1852839
/api/keyword/1852839
true
true
SjrRating
10867670
/api/sjrrating/10867670
45
0.49
journal
RatingType
10002
/api/ratingtype/10002
sjr
true
true
ClassificationExternal
1605
/api/classificationexternal/1605
true
1605
true
Q2
DIRECT
true
true
/api/publication/30331520
<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10060683"> <a href="/gui2/?type=authors&mode=browse&sel=10060683" target="_blank">Jójárt, R.</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Pécsy, S. </span> <span class="author-type"> </span> ; <span class="author-name" mtid="1272454"> <a href="/gui2/?type=authors&mode=browse&sel=1272454" target="_blank">Keglevich, G.</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10001367"> <a href="/gui2/?type=authors&mode=browse&sel=10001367" target="_blank">Szécsi, M.</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10068092"> <a href="/gui2/?type=authors&mode=browse&sel=10068092" target="_blank">Rigó, R.</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10011564"> <a href="/gui2/?type=authors&mode=browse&sel=10011564" target="_blank">Ozvegy-Laczka, C.</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10063503"> <a href="/gui2/?type=authors&mode=browse&sel=10063503" target="_blank">Kecskeméti, G.</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10012035"> <a href="/gui2/?type=authors&mode=browse&sel=10012035" target="_blank">Mernyák, E. ✉</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;30331520" mtid="30331520" target="_blank">Pd-Catalyzed microwave-assisted synthesis of phosphonated 13α-estrones as potential OATP2B1, 17β-HSD1 and/or STS inhibitors</a></div> <div class="pub-info"> <span class="journal-title">BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY</span> <span class="journal-volume">14</span> <span class="page"> pp. 2838-2845. , 8 p. </span> <span class="year">(2018)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3762/bjoc.14.262" target="_blank" href="https://doi.org/10.3762/bjoc.14.262"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="88545" target="_blank" href="http://real.mtak.hu/88545"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000451065700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000451065700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85056862646" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85056862646"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="30498534" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30498534&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="14374" target="_blank" href="http://publicatio.bibl.u-szeged.hu/14374"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="deleted-record">Locked</span> <span class="short-pub-mtid"> Publication:30331520 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Validated </span></span> <span class="pub-core">Core Citing </span> <span class="pub-type">Journal Article (Article ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Scientific</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 18</span> | Independent citation: 7 | Self citation: 11 | Unknown citation: 0 | Number of citations in WoS: 16 | Number of citations in Scopus: 15 | WoS/Scopus assigned: 16 | Number of citations with DOI: 16 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
<div class="authors">
<img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png">
<img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png">
<div class="autype autype0"> <span class="author-name" mtid="10060683"><a
href="/gui2/?type=authors&mode=browse&sel=10060683" target="_blank">Jójárt R.
(<span class="authorship-author-name">Jójárt Rebeka</span>
<span class="authorAux-mtmt"> Szerves kémia</span>)
</a>
</span>
<span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Kémiai Intézet">KI</span>/Department of Organic Chemistry</span>
;
<span class="author-name" >Pécsy S.
</span>
;
<span class="author-name" mtid="1272454"><a
href="/gui2/?type=authors&mode=browse&sel=1272454" target="_blank">Keglevich G.
(<span class="authorship-author-name">Keglevich György</span>
<span class="authorAux-mtmt"> Szerves kémia, foszfororganikus környezetbarát ...</span>)
</a>
</span>
<span class="author-affil"><span title="Budapest University of Technology and Economics">BUTE</span>/<span title="Faculty of Chemical Technology and Biotechnology">FCTB</span>/Department of Organic Chemistry and Technology</span>
;
<span class="author-name" mtid="10001367"><a
href="/gui2/?type=authors&mode=browse&sel=10001367" target="_blank">Szécsi M.
(<span class="authorship-author-name">Szécsi Mihály</span>
<span class="authorAux-mtmt"> Szteroidok analitikai kémiája és biokémiája</span>)
</a>
</span>
<span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Medicine">ÁOK</span>/First Department of Internal Medicine</span>
;
<span class="author-name" mtid="10068092"><a
href="/gui2/?type=authors&mode=browse&sel=10068092" target="_blank">Rigó R.
(<span class="authorship-author-name">Laczkó-Rigó Réka</span>
<span class="authorAux-mtmt"> biológus</span>)
</a>
</span>
;
<span class="author-name" mtid="10011564"><a
href="/gui2/?type=authors&mode=browse&sel=10011564" target="_blank">Ozvegy-Laczka C.
(<span class="authorship-author-name">Laczka Csilla</span>
<span class="authorAux-mtmt"> Biokémia, molekuláris biológia</span>)
</a>
</span>
<span class="author-affil"><span title="MTA Research Centre for Natural Sciences">MTA TTK</span>/<span title="Institute of Enzymology">EI</span>/Enzim_405</span>
;
<span class="author-name" mtid="10063503"><a
href="/gui2/?type=authors&mode=browse&sel=10063503" target="_blank">Kecskeméti G.
(<span class="authorship-author-name">Kecskeméti Gábor</span>
<span class="authorAux-mtmt"> Analitika</span>)
</a>
</span>
<span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Medicine">ÁOK</span>/Department of Medical Chemistry</span>
;
<span class="author-name" mtid="10012035"><a
href="/gui2/?type=authors&mode=browse&sel=10012035" target="_blank">Mernyák E. ✉
(<span class="authorship-author-name">Mernyák Erzsébet</span>
<span class="authorAux-mtmt"> Szerves kémia</span>)
</a>
</span>
<span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Kémiai Intézet">KI</span>/Department of Organic Chemistry</span>
</div>
</div>
<div class="title"><a href="/gui2/?mode=browse¶ms=publication;30331520" target="_blank">Pd-Catalyzed microwave-assisted synthesis of phosphonated 13α-estrones as potential OATP2B1, 17β-HSD1 and/or STS inhibitors</a></div> <div> <span class="journal-title">BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1860-5397">1860-5397</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1860-5397">1860-5397</a>)</span>:
<span class="journal-volume">14</span>
<span class="page">
pp 2838-2845
</span> <span class="year">(2018)</span>
</div>
<div class="pub-footer">
<span class="language" xmlns="http://www.w3.org/1999/html">Language:
English
| </span>
<span class="identifiers">
<span class="id identifier oa_GOLD" title=" Gold
">
<a style="color:blue" title="10.3762/bjoc.14.262" target="_blank" href="https://doi.org/10.3762/bjoc.14.262">
DOI
</a>
</span>
<span class="id identifier oa_GREEN" title=" Green
">
<a style="color:black" title="88545" target="_blank" href="http://real.mtak.hu/88545">
REAL
</a>
</span>
<span class="id identifier oa_none" title="none">
<a style="color:blue" title="000451065700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000451065700001">
WoS
</a>
</span>
<span class="id identifier oa_none" title="none">
<a style="color:blue" title="85056862646" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85056862646">
Scopus
</a>
</span>
<span class="id identifier oa_none" title="none">
<a style="color:blue" title="30498534" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30498534&dopt=Abstract">
PubMed
</a>
</span>
<span class="id identifier oa_GREEN" title=" Green
">
<a style="color:blue" title="14374" target="_blank" href="http://publicatio.bibl.u-szeged.hu/14374">
SZTE Publicatio
</a>
</span>
</span>
<div class="publication-citation" style="margin-left: 0.5cm;">
<span title="" class="citingPub-count">Citing papers: 18</span>
| Independent citation: 7
| Self citation: 11
| Unknown citation: 0
| Number of citations in WoS: 16
| Number of citations in Scopus: 15
| WoS/Scopus assigned: 16
| Number of citations with DOI: 16
</div>
<div class="publication-citation">
<a target="_blank" href="/api/publication?cond=citations.related;eq;30331520&sort=publishedYear,desc&sort=title">
Number of cited publications: 9
</a>
</div>
<div class="mtid"><span class="long-pub-mtid">Publication: 30331520</span>
| <span class="status-data status-VALIDATED"> Validated
</span>
Core Citing
| <span class="type-subtype">Journal Article
( Article
)
</span>
| <span class="pub-category">Scientific</span>
| <span class="publication-sourceOfData">Scopus (scopus.ris, 2018-11-28)</span>
</div>
<div class="lastModified">Last Modified: 2021.01.13. 14:21 Réka Laczkó-Rigó (biológus)
</div>
<div class="lockedBy">Temporarily locked 2023.01.17. 09:55 Katalin Mikola (MTMT 3, admin)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Organic Chemistry, University of Szeged, Dóm tér 8, Szeged, H-6720, Hungary
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, H-1521, Hungary
1st Department of Medicine, University of Szeged, Korányi fasor 8-10, Szeged, H-6720, Hungary
Membrane protein r...</pre>
</div></div>