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preeclampsia is associated with alterations in placental microRNA expression. Previous reports have shown that hsa-miR-181a-5p is overexpressed in human preeclamptic placenta compared with normotensive placenta. The purpose of this study was to explore whether upregulated hsa-miR-181a-5p expression is involved in the ontogenesis of preeclampsia.Twenty preeclamptic placentas and 20 normotensive placentas were obtained from nulliparous women by cesarean section. Expression of hsa-miR-181a-5p in placenta tissues and human trophoblast cell lines was analyzed by reverse transcription polymerase chain reaction. The trophoblast cell lines (HTR-8/SVneo and JAR) were transfected with specific oligonucleotides to upregulate miR-181a-5p expression. The effect of miR-181a-5p expression on proliferation, cell cycle, apoptosis, and invasion in HTR-8/SVneo and JAR cells was then investigated.It was demonstrated that hsa-miR-181a-5p expression was upregulated in preeclamptic placentas and that it may trigger antiproliferation and inhibition of cell cycle progression, induce apoptosis, and suppress invasion in HTR-8/SVneo and JAR cells.Anomalously upregulated hsa-miR-181a-5p expression could contribute to trophoblast dysfunction and may be a crucial factor in the pathogenesis of preeclampsia.", "keywords" : [ { "otype" : "Keyword", "mtid" : 13977, "link" : "/api/keyword/13977", "label" : "placenta", "published" : true, "oldId" : 13977, "snippet" : true }, { "otype" : "Keyword", "mtid" : 17331, "link" : "/api/keyword/17331", "label" : "PREECLAMPSIA", "published" : true, "oldId" : 17331, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1510570, "link" : "/api/keyword/1510570", "label" : "Hsa-miR-181a-5p", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1510571, "link" : "/api/keyword/1510571", "label" : "trophoblast cell lines", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2018, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2022-08-26", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 1, "citedCount" : 1, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10864608, "link" : "/api/sjrrating/10864608", "label" : "sjr:Q2 (2019) Scopus - Obstetrics and Gynecology REPRODUCTIVE SCIENCES 1933-7191 1933-7205", "listPos" : 47, "rankValue" : 0.49, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2729, "link" : "/api/classificationexternal/2729", "label" : "Scopus - Obstetrics and Gynecology", "published" : true, "oldId" : 2729, "snippet" : true }, "ranking" : "Q2", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q2", "hasCitationDuplums" : false, "userChangeableUntil" : "2019-05-05T11:07:54.580+0000", "publishDate" : "2019-02-04T12:07:54.637+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 6, "ownerInstituteCount" : 17, "directInstituteCount" : 0, "authorCount" : 5, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/30329471", "label" : "Huang Xiaohao et al. 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