https://m2.mtmt.hu/eng2026-10-25 01:01JournalArticle30322282APPROVEDtrueFunding Agency and Grant Number: Hungarian Brain Research Program Grant [2017-1.2.1-NKP-2017-00002, KTIA_NAP_13-2-2015-0010]; European Union [VEKOP-2.3.2-16-2017-00013]; State of Hungary - European Regional Development Fund; Hungarian National Research, Development and Innovation Office [PD124175, PD121015, PD121123, FK124434, KKP126998]
Funding text: The research leading to these results has received funding from the Hungarian Brain Research Program Grant (Grant No. 2017-1.2.1-NKP-2017-00002 to I.U.; KTIA_NAP_13-2-2015-0010 to F.M.). The research within project No. VEKOP-2.3.2-16-2017-00013 by I. Ulbert was supported by the European Union and the State of Hungary, co-financed by the European Regional Development Fund. R. Fiath, G. Marton, K. Toth and F. Matyas are thankful to the Hungarian National Research, Development and Innovation Office (PD124175 to R.F., PD121015 to G.M., PD121123 to K.T., FK124434 and KKP126998 to F.M.).0false2026-10-19T08:06:00.681+00002026-02-09T15:16:10.153+00002018-11-20T14:53:38.008+0000true10015824FiáthRichárd
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REVIEWEDtruefalse10019966false10019966true2045-2322JournalFOREIGN91111111172019Neural probes designed for extracellular recording of brain electrical activity are traditionally implanted with an insertion speed between 1 µm/s and 1 mm/s into the brain tissue. Although the physical effects of insertion speed on the tissue are well studied, there is a lack of research investigating how the quality of the acquired electrophysiological signal depends on the speed of probe insertion. In this study, we used four different insertion speeds (0.002 mm/s, 0.02 mm/s, 0.1 mm/s, 1 mm/s) to implant high-density silicon probes into deep layers of the somatosensory cortex of ketamine/xylazine anesthetized rats. After implantation, various qualitative and quantitative properties of the recorded cortical activity were compared across different speeds in an acute manner. Our results demonstrate that after the slowest insertion both the signal-to-noise ratio and the number of separable single units were significantly higher compared with those measured after inserting probes at faster speeds. Furthermore, the amplitude of recorded spikes as well as the quality of single unit clusters showed similar speed-dependent differences. Post hoc quantification of the neuronal density around the probe track showed a significantly higher number of NeuN-labelled cells after the slowest insertion compared with the fastest insertion. Our findings suggest that advancing rigid probes slowly (~1 µm/s) into the brain tissue might result in less tissue damage, and thus in neuronal recordings of improved quality compared with measurements obtained after inserting probes with higher speeds.truetrue2018truetruetruefalsetruefalseGOLD2026-10-19truehttps://doi.org/10.1038/s41598-018-36816-z97097781897979793979778787819097789778077FolyóiratcikkJournal Article2495KönyvrészletChapter in Book252KönyvBook230Egyéb konferenciaközleményConference paper310Egyéb konferenciakötetConference proceedings320Oltalmi formákProtection forms260DisszertációThesis280EgyébMiscellaneous290AlkotásAchievement220Kutatási adatResearch data330FolyóiratcikkJournal Article24000KönyvrészletChapter in Book25000KönyvBook23000Egyéb konferenciaközleményConference paper31000Egyéb konferenciakötetConference proceedings32000Oltalmi formákProtection forms26000DisszertációThesis28000EgyébMiscellaneous29000AlkotásAchievement22000Kutatási adatResearch data3300020190212120200868620210128128202201412141220230969620240282428242025098982026015131513D1A nemzetközifalse10036458,192,10018150falsefalsefalse2019-02-18T14:54:54.247+00002018-11-20T14:54:54.481+0000Anatómiai és Szövettani Tanszék (ÁTE); Információs Technológiai és Bionikai Kar (PPKE); Kognitív Idegtudományi és Pszichológiai Intézet (HRN TTK); MTA-TTK-NAP B Hálózat és Viselkedés Neurobiológ... (HRN TTK / KPI); Neuronhálózat és Dendritikus Aktivitás Kutatócs... (HRN KOKI); Összehasonlító Pszichofiziológiai Kutatócsoport (HRN TTK / KPI)664670trueLanguage10002
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10018150"> <a href="/gui2/?type=authors&mode=browse&sel=10018150" target="_blank">Fiáth, R ✉</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Márton, AL </span> <span class="author-type"> </span> ; <span class="author-name" mtid="163"> <a href="/gui2/?type=authors&mode=browse&sel=163" target="_blank">Mátyás, F</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10069397"> <a href="/gui2/?type=authors&mode=browse&sel=10069397" target="_blank">Pinke, D</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10036458"> <a href="/gui2/?type=authors&mode=browse&sel=10036458" target="_blank">Márton, G</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="192"> <a href="/gui2/?type=authors&mode=browse&sel=192" target="_blank">Tóth, K</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10001193"> <a href="/gui2/?type=authors&mode=browse&sel=10001193" target="_blank">Ulbert, I</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;30322282" mtid="30322282" target="_blank">Slow insertion of silicon probes improves the quality of acute neuronal recordings</a></div> <div class="pub-info"> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-volume">9</span> : <span class="journal-issue">1</span> <span class="page"> Paper: 111 , 17 p. </span> <span class="year">(2019)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41598-018-36816-z" target="_blank" href="https://doi.org/10.1038/s41598-018-36816-z"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="89872" target="_blank" href="https://real.mtak.hu/89872"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000455592300032" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000455592300032"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85060050743" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85060050743"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="30643182" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30643182&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="PMC6331571" target="_blank" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331571"> Pubmed Central </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Publication:30322282 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Published </span></span> <span class="pub-core">Core Citing </span> <span class="pub-type">Journal Article (Article ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Scientific</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 97</span> | Independent citation: 78 | Self citation: 19 | Unknown citation: 0 | Number of citations in WoS: 97 | Number of citations in Scopus: 93 | WoS/Scopus assigned: 97 | Number of citations with DOI: 97 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
<div class="authors">
<img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png">
<img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png">
<div class="autype autype0"> <span class="author-name" mtid="10018150"><a
href="/gui2/?type=authors&mode=browse&sel=10018150" target="_blank">Fiáth R ✉
(<span class="authorship-author-name">Fiáth Richárd</span>
<span class="authorAux-mtmt"> Idegtudomány</span>)
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<span class="author-affil"><span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar; <span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Cognitive Neuroscience and Psychology">KPI</span>/Összehasonlító Pszichofiziológiai Kutatócsoport</span>
;
<span class="author-name" >Márton AL
</span>
;
<span class="author-name" mtid="163"><a
href="/gui2/?type=authors&mode=browse&sel=163" target="_blank">Mátyás F
(<span class="authorship-author-name">Mátyás Ferenc</span>
<span class="authorAux-mtmt"> Neurobiológia</span>)
</a>
</span>
<span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Cognitive Neuroscience and Psychology">KPI</span>/MTA-TTK-NAP B Neuronal Network and Behaviour Research Group; <span title="University of Veterinary Medicine Budapest">UVMB</span>/Department of Anatomy and Histology</span>
;
<span class="author-name" mtid="10069397"><a
href="/gui2/?type=authors&mode=browse&sel=10069397" target="_blank">Pinke D
(<span class="authorship-author-name">Pinke Domonkos Péter</span>
<span class="authorAux-mtmt"> Neurobiológia</span>)
</a>
</span>
<span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/<span title="Department of Pharmacology">DP</span>/Neuronhálózat és Dendritikus Aktivitás Kutatócsoport</span>
;
<span class="author-name" mtid="10036458"><a
href="/gui2/?type=authors&mode=browse&sel=10036458" target="_blank">Márton G
(<span class="authorship-author-name">Márton Gergely</span>
<span class="authorAux-mtmt"> Villamosmérnök</span>)
</a>
</span>
<span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Cognitive Neuroscience and Psychology">KPI</span>/Összehasonlító Pszichofiziológiai Kutatócsoport</span>
;
<span class="author-name" mtid="192"><a
href="/gui2/?type=authors&mode=browse&sel=192" target="_blank">Tóth K
(<span class="authorship-author-name">Tóth Kinga</span>
<span class="authorAux-mtmt"> Neurobiológia</span>)
</a>
</span>
<span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Cognitive Neuroscience and Psychology">KPI</span>/Összehasonlító Pszichofiziológiai Kutatócsoport</span>
;
<span class="author-name" mtid="10001193"><a
href="/gui2/?type=authors&mode=browse&sel=10001193" target="_blank">Ulbert I
(<span class="authorship-author-name">Ulbert István</span>
<span class="authorAux-mtmt"> Idegtudományok</span>)
</a>
</span>
<span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Cognitive Neuroscience and Psychology; <span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Cognitive Neuroscience and Psychology">KPI</span>/Összehasonlító Pszichofiziológiai Kutatócsoport</span>
</div>
</div>
<div class="title"><a href="/gui2/?mode=browse¶ms=publication;30322282" target="_blank">Slow insertion of silicon probes improves the quality of acute neuronal recordings</a></div> <div> <span class="journal-title">SCIENTIFIC REPORTS</span>
<span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>)</span>:
<span class="journal-volume">9</span> <span class="journal-issue">1</span>
<span class="page">
Paper 111.
17 p.
</span> <span class="year">(2019)</span>
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<div class="pub-footer">
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English
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<span class="identifiers">
<span class="id identifier oa_GOLD" title=" Gold
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<a style="color:blue" title="10.1038/s41598-018-36816-z" target="_blank" href="https://doi.org/10.1038/s41598-018-36816-z">
DOI
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<OnlyViewableByAuthor><div class="ratings">
<div class="journal-subject">Journal subject: Scopus - Multidisciplinary Rank: D1</div>
<div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-] A nemzetközi</div>
<div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-] B nemzetközi</div>
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<div class="publication-citation" style="margin-left: 0.5cm;">
<span title="" class="citingPub-count">Citing papers: 97</span>
| Independent citation: 78
| Self citation: 19
| Unknown citation: 0
| Number of citations in WoS: 97
| Number of citations in Scopus: 93
| WoS/Scopus assigned: 97
| Number of citations with DOI: 97
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<a target="_blank" href="/api/publication?cond=citations.related;eq;30322282&sort=publishedYear,desc&sort=title">
Number of cited publications: 7
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<div class="mtid"><span class="long-pub-mtid">Publication: 30322282</span>
| <span class="status-data status-APPROVED"> Published
</span>
Core Citing
| <span class="type-subtype">Journal Article
( Article
)
</span>
| <span class="pub-category">Scientific</span>
| <span class="publication-sourceOfData">kézi felvitel</span>
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<div class="lastModified">Last Modified: 2026.02.09. 16:16 Richárd Fiáth (MTA TTK Idegtudomány, admin)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: Hungarian Brain Research Program Grant [2017-1.2.1-NKP-2017-00002, KTIA_NAP_13-2-2015-0010]; European Union [VEKOP-2.3.2-16-2017-00013]; State of Hungary - European Regional Development Fund; Hungarian National Research, Development and Innovation Office [PD124175, PD121015, PD121123, FK124434, KKP126998]
Funding text: The research leading to these r...</pre>
</div></div>