https://m2.mtmt.hu/ eng 2026-10-24 05:10 JournalArticle 30319311 VALIDATED true 0 false 2026-10-22T15:03:17.045+0000 2026-10-22T13:34:08.641+0000 2018-11-15T17:56:48.074+0000 true 10010125 Ferdinandy Péter /api/author/10010125 Author true 10010125 2026-10-21T11:42:56.643+0000 2026-10-21T11:42:56.643+0000 2026-04-20T08:57:37.827+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Hausenloy, Derek J The coronary circulation in acute myocardial ischaemia/reperfusion injury - a target for cardioprotection true true /api/journal/926 REVIEWED true false 926 false 926 true 0008-6363 1755-3245 Journal FOREIGN 115 7 1143 1155 1143 13 2019 The coronary circulation is both culprit and victim of acute myocardial infarction. The rupture of an epicardial atherosclerotic plaque with superimposed thrombosis causes coronary occlusion, and this occlusion must be removed to induce reperfusion. However, ischaemia and reperfusion cause damage not only in cardiomyocytes but also in the coronary circulation, including microembolisation of debris and release of soluble factors from the culprit lesion, impairment of endothelial integrity with subsequently increased permeability and oedema formation, platelet activation and leukocyte adherence, erythrocyte stasis, a shift from vasodilation to vasoconstriction, and ultimately structural damage to the capillaries with eventual no-reflow, microvascular obstruction and intramyocardial haemorrhage. Therefore, the coronary circulation is a valid target for cardioprotection, beyond protection of the cardiomyocyte. Virtually all of the above deleterious endpoints have been demonstrated to be favourably influenced by one or the other mechanical or pharmacological cardioprotective intervention. However, no-reflow is still a serious complication of reperfused myocardial infarction and carries, independently from infarct size, an unfavourable prognosis. Microvascular obstruction and intramyocardial haemorrhage can be diagnosed by modern imaging technologies, but still await an effective therapy. The current review provides an overview of strategies to protect the coronary circulation from acute myocardial ischaemia/reperfusion injury. This article is part of a Cardiovascular Research Spotlight Issue entitled 'Cardioprotection Beyond the Cardiomyocyte', and emerged as part of the discussions of the European Union (EU)-CARDIOPROTECTION Cooperation in Science and Technology (COST) Action, CA16225. true true 2018 true true true false true false GOLD 2026-10-22 true https://doi.org/10.1093/cvr/cvy286 256 0 255 231 6 255 254 242 232 255 255 231 231 232 24 0 256 232 255 231 0 8 8 Folyóiratcikk Journal Article 24 255 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 1 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák 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/api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 30428011 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30428011&dopt=Abstract false true SjrRating 10758774 /api/sjrrating/10758774 22 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true D1 DIRECT true true /api/publication/30319311 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Hausenloy Derek J ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chilian William </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Crea Filippo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Davidson Sean M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy Peter (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Garcia-Dorado David </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >van Royen Niels </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schulz Rainer </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Heusch Gerd ✉ </span> </div> <div class="autype autype-29"> Collaborative Organization: <span class="author-name" >EU-CARDIOPROTECTION COST Action </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30319311" target="_blank">The coronary circulation in acute myocardial ischaemia/reperfusion injury - a target for cardioprotection</a></div> <div> <span class="journal-title">CARDIOVASCULAR RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0008-6363">0008-6363</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1755-3245">1755-3245</a>)</span>: <span class="journal-volume">115</span> <span class="journal-issue">7</span> <span class="page"> pp 1143-1155 </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1093/cvr/cvy286" target="_blank" href="https://doi.org/10.1093/cvr/cvy286"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000482132500004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000482132500004"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="8048" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/8048"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85066487438" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85066487438"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="30428011" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30428011&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Physiology (medical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Physiology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 256</span> | Independent citation: 232 | Self citation: 24 | Unknown citation: 0 | Number of citations in WoS: 242 | Number of citations in Scopus:&nbsp;232 | WoS/Scopus assigned:&nbsp;255 | Number of citations with DOI:&nbsp;254 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30319311&sort=publishedYear,desc&sort=title"> Number of cited publications: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 30319311</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed (pubmed_result.xml, 2018-11-15)</span> </div> <div class="notDuplums"><a target="_blank" href="/api/publication/30319311/notduplums">5 marked as not duplum</a> </div> <div class="lastModified">Last Modified: 2026.10.22. 15:34 Éva Pécsi (MTMT Közp 2,3, admin) </div> </div></div>