https://m2.mtmt.hu/ eng 2026-09-21 16:49 JournalArticle 30319311 VALIDATED true Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore National Heart Research Institute Singapore, National Heart Centre, Singapore, Singapore Yong Loo Lin School of Medicine, National University Singapore, Singapore, Singapore Hatter Cardiovascular Institute, University College London, London, United Kingdom National Institute of Health Research, University College London Hospitals Biomedical Research Centre, Research and Development, London, United Kingdom Department of Cardiology, Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom Department of Integrative Medical Sciences, Northeast Ohio Medical University, 4209 State Route 44, Rootstown, United States Department of Cardiovascular and Thoracic Sciences, Fpoliclinico Gemelli-IRCCS, Università Cattolica Sacro Cuore, Roma, Italy Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary Pharmahungary Group, Szeged, Hungary Department of Cardiology, Vascular Biology and Metabolism Area, Vall d'Hebron University Hospital and Research Institute (VHIR), Barcelona, Spain Instituto CIBER de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain Department of Cardiology, Radboud University Medical Center, Nijmegen, Netherlands Institute of Physiology, Justus-Liebig University Giessen, Giessen, Germany Institute for Pathophysiology, West German Heart and Vascular Center, University of Essen Medical School, Essen, Germany Cited By :92 Export Date: 9 November 2022 CODEN: CVREA Correspondence Address: Hausenloy, D.J.; Cardiovascular and Metabolic Disorders Program, Singapore; email: derek.hausenloy@duke-nus.edu.sg Funding text 1: This work was supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre [to S.M.D. and D.J.H.]; British Heart Foundation (FS/10/039/28270 to D.J.H.); Duke-National University Singapore Medical School [to D.J.H.]; Singapore Ministry of Health’s National Medical Research Council under its Clinician Scientist-Senior Investigator scheme [NMRC/CSA-SI/0011/2017 to D.J.H.] and Collaborative Centre Grant scheme [NMRC/CGAug16C006 to D.J.H.); Singapore Ministry of Education Academic Research Fund Tier 2 [MOE2016-T2-2-021 to D.J.H.]; German Research Foundation [He 1320/18-3 and SFB 1116 B8 to G.H.] and [SFB/CRC 1213 B05 to R.S.]; National Research, Development and Innovation Office of Hungary [NVKP_16-1-2016-0017; OTKA KH 125570; OTKA 115378]; the Higher Education Institutional Excellence Programme of the Ministry of Human Capacities in Hungary, within the framework of the Therapeutic Development thematic programme of the Semmelweis University [to P.F.]; the Instituto de Salud Carlos III, CIBERCV-Instituto de Salud Carlos III, Spain [CB16/11/00479, co-funded with European Regional Development Fund-FEDER contribution to D.G.D.]; and PIE/2013-00047 and PI 17/1397 [to D.G.D.]. This article is based upon work from COST Action EU-CARDIOPROTECTION CA16225 supported by COST (European Cooperation in Science and Technology). 0 false 2026-08-20T18:27:40.512+0000 2026-04-20T08:57:37.565+0000 2018-11-15T17:56:48.074+0000 true 10010125 Ferdinandy Péter /api/author/10010125 Author true 10010125 2026-04-20T08:57:21.299+0000 2026-04-20T08:57:21.299+0000 2026-04-20T08:57:37.827+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Hausenloy, Derek J The coronary circulation in acute myocardial ischaemia/reperfusion injury - a target for cardioprotection true true /api/journal/926 REVIEWED true false 926 false 926 true 0008-6363 1755-3245 Journal FOREIGN 115 7 1143 1155 1143 13 2019 The coronary circulation is both culprit and victim of acute myocardial infarction. The rupture of an epicardial atherosclerotic plaque with superimposed thrombosis causes coronary occlusion, and this occlusion must be removed to induce reperfusion. However, ischaemia and reperfusion cause damage not only in cardiomyocytes but also in the coronary circulation, including microembolisation of debris and release of soluble factors from the culprit lesion, impairment of endothelial integrity with subsequently increased permeability and oedema formation, platelet activation and leukocyte adherence, erythrocyte stasis, a shift from vasodilation to vasoconstriction, and ultimately structural damage to the capillaries with eventual no-reflow, microvascular obstruction and intramyocardial haemorrhage. Therefore, the coronary circulation is a valid target for cardioprotection, beyond protection of the cardiomyocyte. Virtually all of the above deleterious endpoints have been demonstrated to be favourably influenced by one or the other mechanical or pharmacological cardioprotective intervention. However, no-reflow is still a serious complication of reperfused myocardial infarction and carries, independently from infarct size, an unfavourable prognosis. Microvascular obstruction and intramyocardial haemorrhage can be diagnosed by modern imaging technologies, but still await an effective therapy. The current review provides an overview of strategies to protect the coronary circulation from acute myocardial ischaemia/reperfusion injury. This article is part of a Cardiovascular Research Spotlight Issue entitled 'Cardioprotection Beyond the Cardiomyocyte', and emerged as part of the discussions of the European Union (EU)-CARDIOPROTECTION Cooperation in Science and Technology (COST) Action, CA16225. true true 2018 true true true false true false GOLD 2026-08-20 true https://doi.org/10.1093/cvr/cvy286 246 0 245 221 6 245 244 232 226 245 245 221 221 222 24 0 246 222 245 221 0 8 8 Folyóiratcikk Journal Article 24 245 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 1 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák 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/api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 30428011 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30428011&dopt=Abstract false true SjrRating 10758774 /api/sjrrating/10758774 22 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true D1 DIRECT true true /api/publication/30319311 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Hausenloy Derek J ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chilian William </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Crea Filippo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Davidson Sean M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy Peter (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Garcia-Dorado David </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >van Royen Niels </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schulz Rainer </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Heusch Gerd ✉ </span> </div> <div class="autype autype-29"> Collaborative Organization: <span class="author-name" >EU-CARDIOPROTECTION COST Action </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30319311" target="_blank">The coronary circulation in acute myocardial ischaemia/reperfusion injury - a target for cardioprotection</a></div> <div> <span class="journal-title">CARDIOVASCULAR RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0008-6363">0008-6363</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1755-3245">1755-3245</a>)</span>: <span class="journal-volume">115</span> <span class="journal-issue">7</span> <span class="page"> pp 1143-1155 </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1093/cvr/cvy286" target="_blank" href="https://doi.org/10.1093/cvr/cvy286"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000482132500004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000482132500004"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="8048" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/8048"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85066487438" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85066487438"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="30428011" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30428011&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Physiology (medical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Physiology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 246</span> | Independent citation: 222 | Self citation: 24 | Unknown citation: 0 | Number of citations in WoS: 232 | Number of citations in Scopus:&nbsp;226 | WoS/Scopus assigned:&nbsp;245 | Number of citations with DOI:&nbsp;244 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30319311&sort=publishedYear,desc&sort=title"> Number of cited publications: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 30319311</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed (pubmed_result.xml, 2018-11-15)</span> </div> <div class="notDuplums"><a target="_blank" href="/api/publication/30319311/notduplums">5 marked as not duplum</a> </div> <div class="lastModified">Last Modified: 2026.04.20. 10:57 Márta Molnár-Taga (SE 4-es admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore National Heart Research Institute Singapore, National Heart Centre, Singapore, Singapore Yong Loo Lin School of Medicine, National University Singapore, Singapore, Singapore Hatter Cardiovascular Instit...</pre> </div></div>