Copper signalling: causes and consequences

Kardos, Julianna [Kardos, Julianna (Neurokémia, az id...), szerző]; Héja, László [Héja, László (Neurokémia), szerző] Szerves Kémiai Intézet (MTA TTK); Simon, Ágnes [Simon, Ágnes (Fehérjék számítóg...), szerző]; Jablonkai, István [Jablonkai, István (Szerves kémia), szerző]; Kovács, Richard [Kovács, Richárd, szerző]; Jemnitz, Katalin [Jemnitz, Katalin (Biokémia, toxikol...), szerző]

Angol nyelvű Tudományos Összefoglaló cikk (Folyóiratcikk)
Megjelent: CELL COMMUNICATION AND SIGNALING 1478-811X 16 (1) p. 71 Paper: 71 , 21 p. 2018
  • SJR Scopus - Biochemistry: D1
    Copper-containing enzymes perform fundamental functions by activating dioxygen (O-2) and therefore allowing chemical energy-transfer for aerobic metabolism. The copper-dependence of O-2 transport, metabolism and production of signalling molecules are supported by molecular systems that regulate and preserve tightly-bound static and weakly-bound dynamic cellular copper pools. Disruption of the reducing intracellular environment, characterized by glutathione shortage and ambient Cu(II) abundance drives oxidative stress and interferes with the bidirectional, copper-dependent communication between neurons and astrocytes, eventually leading to various brain disease forms. A deeper understanding of of the regulatory effects of copper on neuro-glia coupling via polyamine metabolism may reveal novel copper signalling functions and new directions for therapeutic intervention in brain disorders associated with aberrant copper metabolism.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2020-07-07 08:29