https://m2.mtmt.hu/ eng 2026-04-30 19:01 JournalArticle 30317652 APPROVED true Funding Agency and Grant Number: National Research, Development and Innovation Office, Hungary (Medinprot synergy grant) [K-125340, K-120391, KH-125597, TET_16-1-2016-0134, 2017-1.2.1-NKP-2017-00002]; Korea-Pan-European Research Agreement Funding text: This research was funded by the National Research, Development and Innovation Office, Hungary (grants: K-125340 (A.T.), K-120391 (J.K.), KH-125597 (J.K. and A.T.), TET_16-1-2016-0134 (J.K.), 2017-1.2.1-NKP-2017-00002 (J.K.), Medinprot synergy grant (A.T. and J.K.)) and a Korea-Pan-European Research Agreement (A.T.). Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, H-1117, Hungary ELTE NAP Neuroimmunology Research Group, Department of Biochemistry, Eötvös Loránd University, Budapest, H-1117, Hungary Export Date: 9 July 2019 Correspondence Address: Tantos, Á.; Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of SciencesHungary; email: tantos.agnes@ttk.mta.hu Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, H-1117, Hungary ELTE NAP Neuroimmunology Research Group, Department of Biochemistry, Eötvös Loránd University, Budapest, H-1117, Hungary Export Date: 10 July 2019 Correspondence Address: Tantos, Á.; Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of SciencesHungary; email: tantos.agnes@ttk.mta.hu Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, H-1117, Hungary ELTE NAP Neuroimmunology Research Group, Department of Biochemistry, Eötvös Loránd University, Budapest, H-1117, Hungary Export Date: 4 September 2019 Correspondence Address: Tantos, Á.; Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of SciencesHungary; email: tantos.agnes@ttk.mta.hu 0 false 2026-04-23T00:45:26.378+0000 2020-12-06T02:03:11.323+0000 2018-11-13T12:38:50.881+0000 true 10000649 Buday László /api/author/10000649 Author true 10000649 2025-03-26T18:15:12.343+0000 2019-02-08T08:28:39.675+0000 true 10065569 Pécsi Éva /api/admin/10065569 Admin true 2019-03-08T18:26:02.193+0000 true 565 WoS import /api/admin/565 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szabó, Beáta Disordered Regions of Mixed Lineage Leukemia 4 (MLL4) Protein Are Capable of RNA Binding. true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 19 11 3478 3478 14 2018 Long non-coding RNAs (lncRNAs) are emerging as important regulators of cellular processes and are extensively involved in the development of different cancers; including leukemias. As one of the accepted methods of lncRNA function is affecting chromatin structure; lncRNA binding has been shown for different chromatin modifiers. Histone lysine methyltransferases (HKMTs) are also subject of lncRNA regulation as demonstrated for example in the case of Polycomb Repressive Complex 2 (PRC2). Mixed Lineage Leukemia (MLL) proteins that catalyze the methylation of H3K4 have been implicated in several different cancers; yet many details of their regulation and targeting remain elusive. In this work we explored the RNA binding capability of two; so far uncharacterized regions of MLL4; with the aim of shedding light to the existence of possible regulatory lncRNA interactions of the protein. We demonstrated that both regions; one that contains a predicted RNA binding sequence and one that does not; are capable of binding to different RNA constructs in vitro. 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href="/gui2/?type=authors&mode=browse&sel=10060353" target="_blank">Murvai Nikoletta (<span class="authorship-author-name">Murvai Nikoletta</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="MTA Research Centre for Natural Sciences">MTA TTK</span>/<span title="Institute of Enzymology">EI</span>/Enzim_407</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10065066"><a href="/gui2/?type=authors&mode=browse&sel=10065066" target="_blank">Abukhairan Rawan (<span class="authorship-author-name">Abukhairan Rawan</span> <span class="authorAux-mtmt"> kémiai tudományok</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018758"><a href="/gui2/?type=authors&mode=browse&sel=10018758" target="_blank">Schád Éva (<span class="authorship-author-name">Schád Éva</span> <span class="authorAux-mtmt"> Szerkezeti biológia</span>) </a> </span> <span class="author-affil"><span title="MTA Research Centre for Natural Sciences">MTA TTK</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014881"><a href="/gui2/?type=authors&mode=browse&sel=10014881" target="_blank">Kardos József (<span class="authorship-author-name">Kardos József</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Biology">Bio_I</span>/Department of Biochemistry; <span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Biology">Bio_I</span>/MTA-ELTE-NAP B Neuroimmunology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048288"><a href="/gui2/?type=authors&mode=browse&sel=10048288" target="_blank">Szeder Bálint (<span class="authorship-author-name">Szeder Bálint</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="MTA Research Centre for Natural Sciences">MTA TTK</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000649"><a href="/gui2/?type=authors&mode=browse&sel=10000649" target="_blank">Buday László (<span class="authorship-author-name">Buday László</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="MTA Research Centre for Natural Sciences">MTA TTK</span>/Institute of Enzymology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011280"><a href="/gui2/?type=authors&mode=browse&sel=10011280" target="_blank">Tantos Ágnes (<span class="authorship-author-name">Tantos Ágnes</span> <span class="authorAux-mtmt"> Molekuláris Biológia</span>) </a> </span> <span class="author-affil"><span title="MTA Research Centre for Natural Sciences">MTA TTK</span>/Institute of Enzymology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30317652" target="_blank">Disordered Regions of Mixed Lineage Leukemia 4 (MLL4) Protein Are Capable of RNA Binding.</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">19</span> <span class="journal-issue">11</span> <span class="page"> Paper 3478. 14 p. </span> <span class="year">(2018)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms19113478" target="_blank" href="https://doi.org/10.3390/ijms19113478"> DOI </a> </span> <span class="id identifier oa_GOLD" title=" Gold 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title="" class="citingPub-count">Citing papers: 10</span> | Independent citation: 7 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 8 | Number of citations in Scopus:&nbsp;10 | WoS/Scopus assigned:&nbsp;10 | Number of citations with DOI:&nbsp;10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30317652&sort=publishedYear,desc&sort=title"> Number of cited publications: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 30317652</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed (pubmed_result (2).xml, 2018-11-13)</span> </div> <div class="lastModified">Last Modified: 2020.12.06. 03:03 import WoS (admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: National Research, Development and Innovation Office, Hungary (Medinprot synergy grant) [K-125340, K-120391, KH-125597, TET_16-1-2016-0134, 2017-1.2.1-NKP-2017-00002]; Korea-Pan-European Research Agreement Funding text: This research was funded by the National Research, Development and Innovation Office, Hungary (grants: K-125340 (A.T.), K-120391 (J.K.), KH-125...</pre> </div></div>